Summary
Project Summary In osteoarthritis (OA), intra-articular inflammation is a key mediator of joint destruction and chronic joint pain. Unfortunately, current strategies to control joint inflammation have largely failed. To address this challenge, our team is developing an innovative metabolic reprogramming strategy for the treatment of knee OA. In our strategy, indoleamine 2,3-dioxygenase (IDO), an immunosupressive enzyme, will be intra-articularly delivered to catabolize tryptophan into kynurenines. Based on IDO’s effect in other tissues, this redirection of tryptophan metabolism will likely dr
