Molecular Studies of Cellular Cytotoxicity

Summary

This research program investigates the innate immune system, focusing on natural killer (NK) cells and their use in cancer treatment, including the study of MHC receptors and genetic variation.

What they want

The program investigates the innate immune system, with a primary focus on natural killer (NK) cells and their application in cancer treatment. It includes the study of the regulation of class I major histocompatibility complex (MHC) receptors (Ly49 in mouse, KIR in human NK cells), identification of molecular mechanisms for variegated expression of these receptors, and genetic variation in KIR and Ly49 genes affecting NK cell responsiveness. Recent progress includes investigating promoter competition in KIR gene expression and the role of lineage-determining transcription factors GATA1 and GATA2 in controlling cell fate determination. The group also participates in multiple collaborative projects with intramural and extramural laboratories.

Deliverables

Publications
Development of techniques to modulate cell fate determination

Risks & flags

This appears to be a description of an existing, awarded research project rather than an open procurement opportunity.