Unraveling alphavirus neuroinvasion: Molecular insights from a stem cell based blood-brain barrier model

The project will determine how previously identified neuroinvasive E2 residues on Sindbis (SINV) and chikungunya (CHIKV) viruses confer the ability to efficiently infect brain microvascular endothelial cells (BMECs). Furthermore, it will identify the host factor that neuroinvasive alphaviruses hijack for efficient BMEC infection and characterize its interactions with the E2 glycoprotein. This work seeks to elucidate virus-BBB interactions that facilitate neuropathogenesis, providing a foundation for therapeutic research. The fellow will advance abilities in experimental design and science communication by executing, presenting, and publishing the results, as well as through coursework and teaching.