Summary
Decline in cognition and the onset of Alzheimer’s disease (AD) and dementia impose a devastating personal and interpersonal burden with huge societal costs. To provide insights into new mechanisms and identify novel targets to prevent AD, dementia and cognition decline, we propose a comprehensive study of plasma and brain lipidomics species and incident AD, dementia and cognition. Lipids are thought to be involved in AD however most studies have examined overall fatty acid composition or total levels of a lipid class without regards to fatty acids. Precise identification of lipid species with
