Summary
This research program aims to understand the molecular mechanisms regulating developmental myelination in the central nervous system, particularly in response to neuronal activity, using zebrafish as a model system.
Mechanisms of Developmental Myelination
US · IL
NIH
grant
awarded
#nih-5R35NS122191-05
What they want
The research focuses on three broad areas of developmental myelination: 1) investigating how neural progenitors are specified as oligodendrocyte precursor cells (OPCs) using single cell RNA-seq data; 2) examining how axo-glial interactions and mRNA localization promote myelin sheath growth; and 3) exploring how microglia, the resident innate immune cells of the CNS, modify myelin coverage on axons in response to neuronal activity.
Deliverables
- Important new insights to the developmental basis of learning, memory and psychiatric disease
- A foundation for designing therapeutic strategies to promote myelination of brains damaged by disease or injury
Technical requirements
- Use of zebrafish as a model system
- Combination of time-lapse imaging with genetic and pharmacological manipulations
- Utilization of single cell RNA-seq data
