Summary
PROJECT SUMMARY/ABSTRACT This proposal will elucidate the various steric and electronic parameters of a P-catalyst necessary for enantioinduction in tandem amidation/amide functionalizations through deoxygenative P(III)/P(V) catalysis; an important transformation for the synthesis of biologically active compounds. This proposal will first examine P- catalyzed enantioselective amidations, followed by P-catalyzed enantioretentive amide functionalizations. Finally, these catalysts will be combined for a one-pot synthesis of enantioenriched secondary nitriles from racemic carboxylic acids, a moie
