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Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-268
Response due Nov 17, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting investigator-initiated R01 research grant applications for clinical trials examining complementary and integrative health interventions delivered through remote modalities or mobile health (mHealth) technologies. Applicants must propose a clinical trial as a required component. The opportunity is a Program Announcement with Review (PAR), meaning NIH has a standing interest in funding meritorious projects in this area. The funding window spans from late 2024 through late 2026, allowing multiple submission cycles.

What they want

Applicants must design and conduct investigator-initiated clinical trials that test complementary and integrative health interventions (e.g., mind-body practices, natural products, integrative medicine approaches) delivered via remote platforms or mobile health (mHealth) technologies. A clinical trial is required per the R01 mechanism. Submissions must conform to NIH R01 application requirements, including human subjects protections, clinical trial registration, and data sharing plans.
Technical requirements
  • Clinical trial design is required (not optional)
  • Interventions must be complementary and/or integrative in nature
  • Delivery must be remote or via mHealth technology
  • Must comply with NIH R01 application requirements
  • Clinical trial registration required
  • Data sharing plan required
  • Human subjects protections must be addressed

How they evaluate

  • NIH peer review scoring criteria: Significance, Investigator(s), Innovation, Approach, Environment (standard R01 review criteria)
Submission: Grants.gov federal grants portal (electronic submission per NIH R01 application guidelines)

Risks & flags

  • Highly specialized scope (complementary/integrative + remote/mHealth + clinical trial) narrows the eligible applicant pool significantly
  • Multi-year open window (2024–2026) is standard for PAR mechanisms but may reflect a targeted research agenda aligned with existing NIH center priorities (e.g., NCCIH)

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Investigator Initiated Clinical Trials of …
Due Nov 17
Onboard ↗