Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)

US · US National Institutes of Health (NIH) grant open #PAR-25-038

Response due Sep 07, 2026 · 00:00 UTC

Summary

This NIH funding opportunity (PAR-25-038) supports basic research into the cellular and molecular biology underlying complex brain disorders. It is structured as an R01 research grant, meaning it funds investigator-initiated, hypothesis-driven scientific projects. Clinical trials are explicitly excluded from this announcement. The opportunity is open for an extended multi-cycle period running from November 2024 through September 2026.

What they want

Applicants must propose research focused on the cellular and molecular biological mechanisms of complex brain disorders. The mechanism is an R01 grant (research project grant), which requires a detailed scientific plan, specific aims, and supporting preliminary data. Clinical trials are not allowed under this announcement. Research must align with NIH and the issuing institute's priority areas in brain disorder biology.

Technical requirements

Research must focus on cellular and molecular biology of complex brain disorders
Clinical trials are explicitly not allowed
Must conform to NIH R01 grant application requirements
Investigator-initiated hypothesis-driven research design required

How they evaluate

Scientific merit (peer review)
Significance and innovation
Approach and rigor
Investigator qualifications
Environment and institutional support

Submission: Grants.gov electronic submission portal (federal grants application system)

Risks & flags

No explicit dollar amounts or value band stated — budget expectations unclear without reading full FOA
Extended open window (nearly 2 years) suggests multiple submission cycles rather than a single competition — applicants should verify specific due dates within the FOA
Agency code 'HHS-NIH11' suggests a specific NIH institute/center is the primary funder, which may narrow priority areas not fully described in the synopsis

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541711

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Cellular and Molecular Biology of Complex …

Due Sep 07

Onboard ↗