Summary
This research project aims to define the regulation and function of the NRF2 transcription factor in promoting breast cancer progression and metastasis by inhibiting pro-inflammatory signaling.
NRF2 suppression of inflammatory signaling and its role in tumor progression
US · IL
NIH
grant
open
#nih-5R01CA292658-02
What they want
The project investigates how NRF2 promotes the survival and local recurrence of mammary tumors following targeted therapy, focusing on its role in metastatic dissemination. It hypothesizes that NRF2 promotes breast cancer progression by inhibiting pro-inflammatory signaling between cancer cells and the tumor immune microenvironment. Specific aims include: 1) defining the mechanism and function of NRF2 regulation of the tumor immune microenvironment; 2) determining the role of NRF2 suppression of inflammatory signaling in promoting the outgrowth of disseminated tumor cells; and 3) testing whether targeting metabolic pathways can prevent the growth of NRF2-high tumors.
Deliverables
- Define the mechanism and function of NRF2 regulation of the tumor immune microenvironment.
- Determine the role of NRF2 suppression of inflammatory signaling in promoting the outgrowth of disseminated tumor cells.
- Test whether targeting metabolic pathways can prevent the growth of NRF2-high tumors.
