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BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)

US · MD National Institutes of Health (NIH) grant open #RFA-MH-26-170
Response due Feb 08, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH), under the BRAIN Initiative, is soliciting R01 research grant applications for the development and validation of novel tools to probe cell-specific and circuit-specific processes in the brain. This is a federal grant opportunity (not a procurement contract), issued via Grants.gov. Clinical trials are explicitly excluded from this funding opportunity. The opportunity opened in November 2024 and accepts applications through February 2027.

What they want

Applicants must propose research focused on developing and validating novel tools capable of probing cell-specific and circuit-specific processes in the brain. Work must align with the NIH BRAIN Initiative's goals. Clinical trials are not permitted under this funding opportunity announcement (FOA). The mechanism is R01 (Research Project Grant).
Technical requirements
  • Research must focus on development and validation of novel tools for probing cell-specific and circuit-specific brain processes
  • Clinical trials are not allowed under this funding opportunity
  • Must comply with NIH R01 grant mechanism requirements
  • Must align with BRAIN Initiative objectives

How they evaluate

Submission: Grants.gov federal grants portal

Risks & flags

  • Extremely long open window (~27 months) may indicate rolling/multiple receipt dates rather than a single competition — applicants should verify specific receipt dates in the full FOA
  • Synopsis only — full program announcement text not provided, limiting full scope assessment

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

BRAIN Initiative: Development and Validati…
Due Feb 08
Onboard