Summary
Research into the dynamics of icosahedral human viruses, specifically their 'breathing' and assembly-disassembly transitions during host cell entry, to understand mechanisms for therapeutic development.
Virus breathing and assembly-disassembly transitions in host-entry
US · IL
NIH
grant
awarded
#nih-1R35GM158169-01
What they want
The research program aims to uncover host-induced changes in pathogenic human viral dynamics by targeting the first critical steps of virus entry into human host cells, focusing on icosahedral human viruses like enveloped RNA viruses (flaviviruses such as dengue and zika), non-enveloped RNA viruses (Coxsackie viruses), and non-enveloped DNA virus (Human Papilloma virus). This will be achieved through the integration of cryo-EM with dynamics mediated by structural mass spectrometry and biophysical and RNA chemistry probes to unravel the dynamics of viral particle host entry and genome egress.
Technical requirements
- integration of cryo-EM with dynamics mediated by structural mass spectrometry and biophysical and RNA chemistry probes
Risks & flags
- This document is a research project summary from NIH RePORTER, not a procurement opportunity (RFP, IFB, RFQ, or sole-source notice). It describes an ongoing or awarded research project, not a solicitation for bids or proposals.
