Defining Protective IgGs to Food Allergy

The research will systematically characterize peanut-specific IgG responses to OIT, focusing on IgG specificity, affinity, and titers, as well as the role of glycosylation in regulating antibody effector functions. It will test the central hypothesis that protective allergen-specific IgGs preferentially bind activating FcγRs. This involves defining IgG signatures from OIT associated with outcomes and determining requirements for protective IgG during food allergy, using a multi-disciplinary approach including biophysics, biochemistry, cellular and molecular immunology, and glycobiology, analyzing samples from clinical trials and testing IgGs in functional models of anaphylaxis.