Summary
Research into the functional role of ATAD2 in prostate cancer progression and metastasis, focusing on its ability to modulate bone colonization and antitumoral immune responses, to develop more efficient therapies.
Role of ATAD2 in Prostate Cancer Progression and Metastasis
US · IL
NIH
grant
awarded
#nih-1R37CA299197-01A1
What they want
The project aims to understand the functional determinants of progression to lethal metastatic prostate cancer. It will investigate the functional significance of ATAD2 expression in prostate cancer progression and metastasis, specifically its ability to modulate bone colonization and antitumoral immune responses, and uncover the underlying chromatin and transcriptional mechanisms through which it acts.
Deliverables
- Uncover novel mechanisms linking metastasis and immune escape
- Pave the way for future biomarker driven targeted therapies
Technical requirements
- Use of state-of-the-art syngeneic mouse models
- Ex-vivo epigenetic editing
- Human organoids
- Advanced tissue engineering technologies
