Summary
This research project aims to elucidate the molecular mechanisms of adhesion G Protein-Coupled Receptors (aGPCRs) and teneurins, develop tools to modulate their activity, and understand their roles in various diseases.
Structural and Functional Studies of Cell-Adhesion Receptors
US · IL
NIH
grant
open
#nih-3R35GM148412-03S1
What they want
The research involves an interdisciplinary approach integrating structural studies of aGPCRs and teneurins and their ligands, biochemical and biophysical assays, protein engineering approaches, and functional assays. It seeks to reveal how signal transduction is mediated within these large receptors, what activates them physiologically, how their evolution diversified their functions, and how to inhibit or activate them using synthetic ligands. The studies will be complemented by mutagenesis, signaling assays, the use of synthetic binders, and physiological analyses performed by collaborators.
Deliverables
- Critical insights into the mechanistic details of aGPCR and teneurin function for future therapeutic development
- Potent and selective synthetic ligands for the scientific community to study aGPCRs and teneurins
Technical requirements
- Structural studies of receptors and their ligands
- Biochemical and biophysical assays
- Protein engineering approaches
- Functional assays
- Mutagenesis
- Signaling assays
- Use of synthetic binders
- Physiological analyses (performed by collaborators)
