Summary
Cells perceive mechanical cues in their local environments, which must be converted into intracellular biochemical signals to modulate cellular physiology and control gene expression. This process of mechanical signal transduction (“mechanotransduction”) is critical for development and frequently dysfunctions in disease states such as cancer. Despite increasing appreciation of its importance for human physiology, the molecular mechanisms of mechanotransduction remain poorly understood, hampering efforts to define mechanistically distinct mechanical signaling pathways, delineate their specific
