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Showing 25 / 21760 · page 55/871
Colonoscopy augmentation with Fluorescence Lifetime Imaging (FLIm): colorectal cancer detection in humans
US National Cancer Institute · grant
PROJECT SUMMARY Colorectal cancer (CRC) is the second leading cause of cancer-related mortality globally, with current screening techniques, such as colonoscopy, demonstrating limitations in accurately detecting subtle structural abnormalit…
Posted May 21, 2026
Natural history of multisystem proteinopathy-1
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY (Project 4: Natural History of MSP1) This proposal’s primary objective is to validate a promising measure of motor function as a future efficacy out- come in a large cohort of patients with multisystem proteinopathy 1 (MSP1)…
Posted May 21, 2026
ADAM10 as a molecular specifier of sepsis
US National Institute of Allergy and Infectious Diseases · grant
PROJECT ABSTRACT This proposed career development award will provide Dr. Danielle Alfano, MD with targeted mentored training to ensure she develops into an independent researcher utilizing both experimental approaches, mouse models, and “om…
Posted May 21, 2026
Production and Validation of monoclonal antibodies to enhance rigor and reproducibility in research vertebrate animal model
US NIH Office of the Director · grant
Project Summary Animal models are critical for biomedical research. They allow us to rapidly test the importance of any gene for development or diseases. Advances in technology now allow us to reduce or eliminate protein expression in the e…
Posted May 21, 2026
IL-1R1 in Endothelial-to-Mesenchymal Activation
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY: Endothelial-to-mesenchymal transition (EndMT) has been detected in atherosclerosis, and the extent of EndMT observed in the human plaques strongly correlates with the severity of the disease, implying clinical relevance of …
Posted May 21, 2026
DelPhi and associated resources: maintenance, development and applications
US National Institute of General Medical Sciences · grant
We are a computational lab and our research is within the areas of Computational Biophysics, Bioinformatics, and modeling molecular effects associated with disease-causing mutations. We develop methods, software, and webservers to enable mo…
Posted May 21, 2026
Epigenomic mechanisms of cardiac fibrosis and heart failure
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY A heart failure diagnosis leads to poor quality of life and a 5-year mortality nearing 50%, underscoring the urgent need for innovative treatments. Clinical evidence strongly links myocardial fibrosis, driven by pathological…
Posted May 21, 2026
Chromatin Regulation of Immune Cells in Myocardial Inflammation
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Ischemic heart disease following myocardial infarction (MI) is a leading cause of global morbidity and mortality. During MI, infiltrating immune cells, particularly monocytes, differentiate into macrophages, adopting both re…
Posted May 21, 2026
Innovative Transformations of Fundamental Synthetic Building Blocks
US National Institute of General Medical Sciences · grant
Project Summary: The value of chemical synthesis in health-related research is closely tied to the ability to efficiently generate medicinal agents from readily available materials. This MIRA application seeks to continue our efforts center…
Posted May 21, 2026
Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transition
US National Cancer Institute · grant
PROJECT SUMMARY Globally, more than 900,000 people are diagnosed with head and neck squamous cell carcinoma (HNSCC) each year, with more that 250,000 dying annually from this cancer. Infection with human papilloma virus (HPV), a known risk …
Posted May 21, 2026
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle choices, defective cellular machineries, and even normal cellu…
Posted May 21, 2026
Forward Genetic Analysis of Human Nuclear Long Non-Coding RNAs
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Certain human nuclear long non-coding RNAs (lncRNAs) represent well-established promising targets for the treatment of cancer, developmental and viral diseases; manipulating their levels is expected to provide therapeutic in…
Posted May 21, 2026
Investigating the mechanism of decision-making in the mitochondrial Protease YME1
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY YME1 is an ATP-dependent protease located in the inner mitochondrial membrane, and plays a central role in executing the functional activities of the mitochondrial protein quality control network. Preserving homeostasis with…
Posted May 21, 2026
2025 Label-Free Single Molecule Sensing Gordon Research Conference
US National Institute of Biomedical Imaging and Bioengineering · grant
Project Summary The ability to precisely detect biomolecules and measure their dynamics is central to our understanding of the origins of debilitating diseases such as Alzheimer’s and Parkinson’s and is a prerequisite for designing more eff…
Posted May 21, 2026
The interplay of maternal antibody and newborn vaccine responses
US National Institute of Allergy and Infectious Diseases · grant
Young infants are at high risk for severe disease following influenza virus infection. The current strategy for protecting infants is to increase antibody in the mother that can be transferred across the placenta to the fetus such that infa…
Posted May 21, 2026
Regulation of the HA stem nanoparticle vaccine response by antigen duration
US National Institute of Allergy and Infectious Diseases · grant
The immune system of young infants exhibits profound alterations compared to that of older children and adults. Notable among these are lower responses to TLR engagement, reduced dendritic cell maturation, reduced Tfh responses, and a stron…
Posted May 21, 2026
Training Program in Immunology and Pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
This renewal application requests continued funding for years 31-35 of a successful, longstanding program for predoctoral training in Immunology and Pathogenesis. Four predoctoral positions are requested. Trainees are typically supported …
Posted May 21, 2026
Precision brain charts for imaging-genomics of schizophrenia and the psychosis spectrum
US National Institute of Mental Health · grant
ABSTRACT An unmet need for psychiatric neuroimaging is a standard developmental frame of reference to benchmark studies of neurodevelopmental conditions such as schizophrenia the psychosis spectrum (PS). Using a modelling approach that has …
Posted May 21, 2026
Radiomics for Clinically-Acquired Brain MRIs of Youth with Neurodevelopmental Disorders
US National Institute of Mental Health · grant
PROJECT ABSTRACT The millions of brain MRIs acquired each year in clinical settings are a vastly underutilized scientific resource. Meanwhile, brain MRIs collected in research studies often struggle to recruit cohorts fully representative o…
Posted May 21, 2026
The Genetics of Personalized Functional MRI Networks
US National Institute of Mental Health · grant
ABSTRACT Variability in the spatial layout of human brain functional networks on the anatomic cortex is a novel phenotype that can be extracted from functional magnetic resonance imaging (fMRI) with transformative potential for combined ima…
Posted May 21, 2026
The Role of Post-Translational Modifications in Bacterial Responses to Methylglyoxal
US National Institute of General Medical Sciences · grant
Project Summary and Abstract Methylglyoxal (MGO) is a highly reactive, toxic molecule that is produced non-enzymatically during central metabolism by virtually all cells. Some microorganisms, including enteric bacteria such as Escherichia c…
Posted May 21, 2026
The Effects of Cue Precision on Medical Imaging Interpretation
US National Institute of General Medical Sciences · grant
PROGRAM SUMMARY: It is undesirable for radiologists to search for only one specific thing at a time, as they may miss unexpected findings. Despite this, there is evidence that prior knowledge and expectations (from clinical history or other…
Posted May 21, 2026
Alzheimer's Prevention Initiative ADAD Colombia Trial Program
US National Institute on Aging · grant
Project Summary/Abstract When the API Autosomal Dominant Alzheimer's Disease (ADAD) Colombia Trial (NCT01998841) was announced in 2012, it launched a new era in AD prevention research. The trial led us to identify ~6,000 persons from the wo…
Posted May 21, 2026
Dystrophin as a novel regulator of the circadian clock in skeletal muscle and the brain
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Duchenne muscular dystrophy (DMD) is a severe and progressive neuromuscular disease that affects 1:5000 live male births, making it the most common form of muscular dystrophy. DMD is caused by the disruption of the …
Posted May 21, 2026
Molecular and therapeutic correction of XMEA using novel zebrafish and mouse models
US National Center for Advancing Translational Sciences · grant
PROJECT SUMMARY/ABSTRACT The objective of this proposal is to define the molecular mechanisms and identify new therapeutic strategies for of an understudied class of myopathies, specifically X-linked myopathy with excessive autophagy (XMEA)…
Posted May 21, 2026