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Showing 25 / 21760 · page 19/871
Mechanisms of cell death in cutaneous melanoma
US National Cancer Institute · grant
PROJECT SUMMARY The incidence of cutaneous melanoma is rising. While small molecule targeted inhibitors and immune checkpoint antibodies have increased long-term survival in advanced-stage cutaneous melanoma, many patients still do not bene…
Posted May 21, 2026
Development and validation of pain models in food animals
US · IL NIH · NAICS 541715 · grant
Development and validation of pain models in food animals Project Summary Each year, more than 65 million piglets, 1 million goats and 15 million calves in the U.S. undergo painful procedures such as tail docking, disbudding, and castratio…
Posted May 21, 2026
Predicting and Monitoring for Cardiac Toxicity in Pediatric AML
US · IL NIH · grant
Abstract: Children with acute myeloid leukemia (AML) receive the maximum cumulative anthracycline exposure during frontline therapy (>440 mg/m2), an exposure that causes very well-described cardiac complications. The importance of acute, s…
Posted May 21, 2026
Collaborative Pathways that Lead to Leukemia
US National Cancer Institute · grant
Mini-chromosome maintenance component 2 (Mcm2) is a DNA replication licensing factor that is part of the Mcm2-7 complex which functions as a DNA helicase, unwinding genomic DNA at the replication fork. Not surprisingly, homozygous deletion …
Posted May 21, 2026
Mutation Mechanisms Leading to Malignant Transformation, Including Chromosomal Translocation and Point Mutations
US · IL NIH · grant
It is well-established that many leukemias are initially sensitive to chemotherapy, but ultimately develop resistance. We have generated a panel of T-ALL cell lines, and have generated chemotherapy-resistatn derivatives of these cell lines,…
Posted May 21, 2026
Activation of Proto-Oncogenes by Chromosomal Translocation
US · IL NIH · grant
CENPA overexpression has been linked to several malignancies, and CENPA overexpression in yeast and cultured cell lines leads to chromosomal mis-segregation and subsequent aneuploidy. In collaboration with Dr. Munira Basrai of the Genetics …
Posted May 21, 2026
Pre-clinical Studies of Therapy for Myelodysplastic Syndrome
US · IL NIH · grant
We have modified a previously established in vivo model of myelodysplastic neoplasm (MDS) to now generate mice that have both wild type (WT) and NHD13 (MDS-derived) hematopoiesis by co-transplantation of WT and NHD13 hematopoietic stem cell…
Posted May 21, 2026
Genome-Wide CRISPR Activation: A Novel Strategy for Identifying Anti-Aging Targets
US National Institute on Aging · grant
The instrumental role of systematic gene knockdown studies, using RNA interference (RNAi), in identifying lifespan-extending gene alterations in model organisms like C. elegans is well established. In contrast, systematic gene overexpressio…
Posted May 21, 2026
Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Two cases of virus eradication (the “Berlin patient” and the “London patient”) demonstrated that a cure for HIV infection is feasible. Meanwhile, the burden of the HIV epidemic, which spreads unabated, as such that for every person living w…
Posted May 21, 2026
Reducing Burnout among VA PCPs Using Evidence-Based Quality Improvement
US · IL Department of Veterans Affairs · NAICS 541720 · grant
Background: Burnout, a long-term psychological response to chronic workplace stress, is highly prevalent among providers and staff in VA primary care. Healthcare worker (HCW) burnout is not only detrimental to affected individuals, but also…
Posted May 21, 2026
Effects of Arginine Depletion Combined with Platinum-Taxane Chemotherapy in Aggressive Variant Prostate Cancers (AVPC)
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Androgen indifferent prostate cancers account for a large proportion of the disease lethality and have limited therapy options, partly due to the lack of identifying biomarkers. To address the unmet need of develop…
Posted May 21, 2026
Deprescribing of Disease Modifying Agents in Older Adults with Multiple Sclerosis
US Agency for Healthcare Research and Quality · grant
PROJECT SUMMARY/ABSTRACT Disease Modifying Agents (DMAs) are vital for reducing inflammation and limiting disease activity in multiple sclerosis (MS). However, there is a decline in inflammation and disease activity in older adults with MS …
Posted May 21, 2026
Morphological and molecular identification of Hyalomma tick vectors of Crimean-Congo Hemorrhagic Fever virus
US · IL NIH · NAICS 541714 · grant
Project Summary/Abstract Ticks are obligate blood-feeders, temporary ectoparasites, and vectors of pathogens to humans and animals. Certain species of the genus Hyalomma are the principal vectors of the virus that causes Crimean-Congo hemor…
Posted May 21, 2026
The identification and interrogation of novel intracellular proteins that underlie the distinct nanoscopic architecture of Neurexin-1 and Neurexin-3
US · IL NIH · grant
Project Summary/Abstract Recent developments in super-resolution imaging have revealed that proteins involved in neurotransmitter release and detection are non-uniformly distributed and assemble into regions of high density called nanoclust…
Posted May 21, 2026
Biochemistry in situ to determine inheritance of RNA-protein complexes
US National Institute of General Medical Sciences · grant
Biochemistry in situ to determine inheritance of RNA-protein complexes The long-term goal is to elucidate the molecular mechanisms how macromolecular RNA-protein complexes transmit information to future generations of cells and progeny. We …
Posted May 21, 2026
Targeting purinergic signaling in Chagas disease
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Chagas disease, a major public health problem in Latin America, is caused by the infection with the protozoan parasite Trypanosoma (T.) cruzi and has been spread to non-endemic regions by migratory movements. Chagas cardiomy…
Posted May 21, 2026
EEG Hyperscan to investigate the Patient-Clinician relationship following Theory of Mind Training
US National Center for Complementary and Integrative Health · grant
Project Summary/Abstract This R21 project aims to enhance therapeutic outcomes for Fibromyalgia (FM) patients by incorporating Theory of Mind (ToM) training into clinical practice. This training is designed to improve patients' ability to u…
Posted May 21, 2026
Initiating Colorectal Cancer Screening in Unscreened Individuals 45 to 54
US · IL NIH · grant
Colorectal cancer (CRC) is the first and second leading cause of cancer death in men and women under 50, respectively. Community health centers (CHCs) predominantly serve low-income individuals and have lower screening rates (41.9%) compare…
Posted May 21, 2026
Chip-Scale Intraoperative Optical Navigation with Immunotargeted Upconverting Nanoparticles
US · IL NIH · grant
Project Summary/Abstract Residual cancer cells left behind following surgery increase the chance of cancer returning in almost every cancer subtype. The current inability to identify these tumor cells during surgery hinders cancer care acr…
Posted May 21, 2026
Early identification of immunotherapy resistance through integrated multiparameter imaging
US National Cancer Institute · grant
PROJECT SUMMARY Immunotherapies for cancer have revolutionized oncology, but most patients do not experience durable responses. Immune checkpoint inhibitors targeting PD-1 and PD-L1 are now FDA-approved for a wide variety of tumors, but non…
Posted May 21, 2026
Developing a Single-Session, Peer-Delivered Internalized Stigma Reduction Intervention for Individuals with Polysubstance Use in Rural Maryland
US National Institute on Drug Abuse · grant
Project Summary/Abstract Rural communities bear a disproportionate burden of opioid and stimulant use, yet many individuals face challenges engaging in and sustaining treatment. Stigmas surrounding substance use disorder (SUD) and medicati…
Posted May 21, 2026
Erythrocyte-derived particles for near infrared phototherapy of port wine stains.
US · IL NIH · grant
Port wine stain (PWS) is a congenital and progressive malformations of the dermal capillaries. Pulsed dye laser (POL) irradiation in the visible wavelength range of 585-600 nm remains as the gold standard of treatment. The underlying tre…
Posted May 21, 2026
Microbiome-derived small molecules and host resistance against Vibrio cholerae
US National Institute of General Medical Sciences · grant
The human body is colonized by a complex microbial community with critical roles for health. This microbiota educates the immune system, helps digest our food, and protects us against pathogens. The diversity of microbes and encoded funct…
Posted May 21, 2026
Oseltamivir Use and Risk of Serious Neuropsychiatric Adverse Events in Children
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY/ABSTRACT Oseltamivir (Tamiflu) is the only Food and Drug Administration (FDA) approved influenza medication for children < 12 years. Yet, oseltamivir is under prescribed, including in children at high risk for influenza comp…
Posted May 21, 2026
Metabolic regulation of exosome biogenesis as a determinant of cancer cell metastasis.
US · IL NIH · grant
Abstract. The studies outlined in this proposal focus on the mechanisms by which aggressive breast cancer cells generate large numbers of exosomes with unique cargo, together with a total secretome that significantly enhances their potentia…
Posted May 21, 2026