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Showing 25 / 21760 · page 21/871
Therapeutic vaccine platform to boost immune responses in Tuberculosis
US National Institute of Allergy and Infectious Diseases · grant
The goal of this SBIR Research Topic is to support small businesses in the development of new drug classes with novel mechanisms of action for HIV, Hepatitis B (HBV), and Tuberculosis (Mtb). HBV and Mtb drugs must be compatible with current…
Posted May 21, 2026
Scientific Conferences and Workshops for the American Psychopathological Association
US National Institute on Drug Abuse · grant
Each year, the Annual Scientific Conference and Workshop Program of the American Psychopathological Association is designed to provide bench science, clinical, and population health researchers with a high quality educational overview of sp…
Posted May 21, 2026
Role of NK cells in control of HCV infection associated hepatocellular carcinoma
US Veterans Affairs · grant
Remarkable advances with hepatitis C Virus (HCV) infection therapy have been made over the past 5 years,. At the same time, the peak of morbidity for the HCV epidemic, including outcomes such as cirrhosis and hepatocellular carcinoma (HCC) …
Posted May 21, 2026
Practice Facilitation to Enhance Implementation of a Pediatric Suicide Prevention Care Pathway
US · IL NIH RePORTER · grant
Project Summary Abstract Suicide is a leading cause of death in youth across the United States. Approximately 80% of youth who die by suicide interface with the medical system in the year preceding their death. Primary care practices (PCPs…
Posted May 21, 2026
Program for Advancing Early-Career Researcher Excellence through Leadership and Management Practices
US National Institute of General Medical Sciences · grant
Project Summary Background: Traditional scientific training prepares investigators to conduct scientific research, but does not adequately prepare early-career investigators to lead and manage their own labs. Yet, when early-career research…
Posted May 21, 2026
Immunoproteomic mechanisms of human macrophage resistance to Mycobacterium tuberculosis infection
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Tuberculosis (TB) is the leading infectious killer worldwide. Upon exposure to Mycobacterium tuberculosis (Mtb), most people develop asymptomatic latent TB infection (LTBI phenotype). However, Dr. Anterasian's col…
Posted May 21, 2026
Deep sequencing of the HIV latent reservoir to discern mechanisms of clonal proliferation and HIV persistence
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT The HIV latent reservoir (LR) is the major barrier to cure of HIV. The persistence of the LR in blood and tissues in people living with HIV (PLWH) during ART is due to cellular proliferation of infected cells. Three…
Posted May 21, 2026
Machine learning and artificial intelligence research for clinical medical image processing
US National Library of Medicine · grant
ML/AI driven automated computer-aided diagnostic (CADx) tools are designed to detect, localize, classify and grade disease in medical images to augment human-expert decision-making, add efficiencies, and improve overall performance. However…
Posted May 21, 2026
Training Grant in Cancer Biology
US National Cancer Institute · grant
This revised application seeks renewal for Years 11-15 of the Training Program in Cancer Biology (T32CB) in the Greenebaum Comprehensive Cancer Center (UMGCCC) at the University of Maryland Baltimore (UMB). We are requesting support for 4 p…
Posted May 21, 2026
Proteolytic Pathways in Venous Thrombus Resolution
US Veterans Affairs · grant
Background / Rationale: VTE (Venous Thromboembolism) is a common and serious cardiovascular disease with significant mortality and morbidity. Prompt anticoagulation of patients with deep venous thrombosis (DVT) reduces fatal pulmonary embol…
Posted May 21, 2026
An engineered prodrug for inhibition of cancer growth and metastasis
US · IL NIH · grant
Treatments for metastatic and recurrent solid tumors, including ovarian, lung and colon cancers, remain a challenge due to lack of potent, selective and effective therapeutics. Clinically approved chemotherapies aim to slow or stop tumor gr…
Posted May 21, 2026
Chemotherapy induced MASP activation and ovarian cancer metastasis
US · IL NIH · grant
SUMMARY Metastasis is the leading cause of high mortality in epithelial ovarian cancer (OC) patients. The most common and insidious OC subtype, high-grade serous ovarian cancer (HGSOC), is often diagnosed after it has already metastasized b…
Posted May 21, 2026
Modulating the resolution of angiogenesis and normalization of the vasculature for therapeutic benefit
US · IL NIH · grant
Cardiovascular diseases are a leading cause of morbidity and mortality worldwide. Defective vascular repair or insufficient vascularization after disrupted or blocked blood flow often lead to ischemic peripheral artery diseases and other ca…
Posted May 21, 2026
2/2 PREEMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis
US National Heart Lung and Blood Institute · grant
Abstract Failure to detect and treat atherosclerosis in younger adults worsens cardiovascular morbidity and mortality. Current strategies of assigning preventive therapies are not based on screening for atherosclerosis, but rather on short-…
Posted May 21, 2026
Developmental Origins of Aggressive and Impulsive Behavior
US · IL NIH · grant
Project Summary. Septal-hypothalamic neuronal activity centrally mediates aggressive behavior, while the monoamine neurotransmitters dopamine and serotonin play strong and mostly opposing modulatory roles. However, related circuit mechanism…
Posted May 21, 2026
Facilitating the Chemistry of Fluorosequencing
US · IL NIH · grant
ABSTRACT While advances in nucleic acid sequencing to achieve parallel and single molecule analysis have been astounding, analogous techniques for peptide/protein sequencing are lacking. Tandem mass-spec analysis still requires millions of …
Posted May 21, 2026
Photoresponsive materials to study matricellular signaling dynamics during crypt formation and fission
US · IL NIH · grant
ABSTRACT The small intestine is lined with a single layer of epithelial cells that is organized into crypt-villus units. These epithelial cells perform multiple functions, such as aiding in digestion, nutrient absorbance, and serving as a b…
Posted May 21, 2026
Hydrogel matrices to study the role of inflammation and biological sex on aortic valve fibrocalcification
US National Heart Lung and Blood Institute · grant
ABSTRACT Thirteen percent of adults over 75 suffer from aortic valve stenosis (AVS), a progressive disease that leads to aberrant collagen deposition, leaflet stiffening, and eventual valve calcification at late stages. AVS is also sexually…
Posted May 21, 2026
Reversing age-related epigenetic changes and characterizing microglia heterogeneity in obesity and aging
US National Institute on Aging · grant
Project Summary Neuroinflammation is a hallmark of brain aging that may contribute to declines in function and neurodegenerative diseases. As the resident macrophage of the brain, microglial are crucial to brain maintenance but have been de…
Posted May 21, 2026
Stabilization of therapeutic microbes for inclusion in a liquid matrix for delivery to the intestines
US · IL NIH · grant
Project Summary/Abstract Enteral feeding (EF) is an essential medical procedure used to supply nutrients directly to the gastrointestinal (GI) tract of patients who are unable to eat independently. EF formula is often purchased as a ready-t…
Posted May 21, 2026
Platform technology for delivery of stabilized therapeutic microbes in powders with high water activity
US · IL NIH · grant
Project Summary/Abstract (NEC) in preterm infants affects 0.3-2.4 infants per 1,000 live births in the US and is a leading cause of mortality (mortality rate of up to 45%) and morbidity in premature babies. Although the pathogenesis of the …
Posted May 21, 2026
Neurobehavioral Effects of Frequent Co-use of Alcohol and Cannabis
US · IL NIH · grant
Project Summary Simultaneous use of alcohol and marijuana/cannabis (SAM) leads to increased craving, use, and consequences compared to single use of either alcohol or cannabis. However, there is a dearth of knowledge regarding the neural, n…
Posted May 21, 2026
MicroRNA directed pathway discovery in allergy and asthma
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY Asthma is a highly prevalent chronic inflammatory airway disease that is genetically and mechanistically linked to allergy and dysregulated cytokine-mediated communication between the airway epithelial barrier and tissue-in…
Posted May 21, 2026
Optimizing the Care of Acute Heart and Lung Diseases through Precision Triage and Inpatient Bed Assignment (OPTIBED)
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Up to 16% of patients hospitalized with acute heart and lung diseases will die during their hospitalization. Mortality is up to three times higher when patients who need ICU-level care are initially triaged to a general care…
Posted May 21, 2026
Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables
US National Heart Lung and Blood Institute · grant
Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables Project Summary/Abstract Research: Heart failure is one of the leading causes of mortality and drivers of healthcare costs in the Unite…
Posted May 21, 2026