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Showing 25 / 21760 · page 23/871
Investigating the contribution of a novel monocyte transcriptional state to sepsis immunopathogenesis and patient heterogeneity
US · IL NIH · grant
Project Summary/Abstract Sepsis is characterized by life-threatening organ failure caused by dysfunctional immune responses to infection; however, the specifics of immune dysfunction are poorly understood and vary widely among patients. Si…
Posted May 21, 2026
Fusion of nanomagnetic and viral tools to interrogate brain-body circuits
US National Center for Complementary and Integrative Health · grant
Abstract The information flow between the peripheral organs and the brain is increasingly recognized as bidirectional, with activity in peripheral circuits influencing high-level behaviors including mood, motivation, and stress. To establis…
Posted May 21, 2026
Development and Validation of an Implementation Penetration Assessment Criteria Tool (ImPACT-HPV) for HPV Vaccination in Nigeria
US National Cancer Institute · grant
There exists a research-to-practice gap that hinders the penetration of human papillomavirus (HPV) vaccination among adolescent girls and young women in Nigeria. To close this gap requires reliable, validated, easy-to-use tools to identify …
Posted May 21, 2026
Point-of-Care and Pharmacy-based Antiretroviral Drug Adherence Assays
US National Institute on Drug Abuse · grant
The Contractor, Guild Associates, Inc., aims to develop an electrochemical aptamer-based sensor device for simple, rapid, and low-cost detection and quantification of antiretroviral therapy (ART) drugs in urine and blood samples at the poin…
Posted May 21, 2026
Identification of genes involved in photoreceptor recognition and synapse formation
US · IL NIH (National Eye Institute - NEI's Retinal Disease Program) · grant
PROJECT SUMMARY/ABSTRACT Vision loss caused by the death of photoreceptors is a leading cause of irreversible blindness worldwide, yet therapeutic options remain limited. For this reason, the NEI's Retinal Disease Program has identified the…
Posted May 21, 2026
Role for nuclear matrix proteins and DNA methylation for XCI maintenance in female lymphocytes
US · IL NIH · grant
Females are predisposed for developing systemic lupus erythematosus (SLE), but the underlying mechanisms remain obscure. Females have two X-chromosomes and equilibration of X-linked gene dosage to that of males (XY) occurs by X-Chromosome I…
Posted May 21, 2026
Gene regulation mechanisms involving the inactive X in B cells during lupus disease
US National Institute of Allergy and Infectious Diseases · grant
Females are predisposed for developing systemic lupus erythematosus (SLE), but the underlying mechanisms remain obscure. Chronic inflammation is also a feature of SLE, and the majority of SLE patients have elevated type I interferon (IFN) l…
Posted May 21, 2026
Mechanisms linking dietary fiber, the microbiome, and satiety
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT This project supports the career development of Dr. Katherene Anguah in her path to become an independent translational researcher focusing on how dietary components may benefit cardiometabolic health through the co…
Posted May 21, 2026
Humanized Mouse Model of Gulf War Veterans' Illness
US Veterans Affairs · grant
Gulf War Veterans' Illnesses (GWVI) is a complex constellation of symptoms that have persisted in Gulf War Veterans (GWV) more than 25 years after their deployment to the Gulf. These symptoms are so diverse, they baffle diagnostic criteria.…
Posted May 21, 2026
Building Research Infrastructure for Alzheimer’s disease and Related Dementias in Côte d’Ivoire to Advance Global and U.S. Health Insights
US National Institute on Aging · grant
PROJECT SUMMARY Most research on Alzheimer’s Disease and Alzheimer’s-Related Dementias (AD/ADRD) is set in higher income contexts in North America, Europe, and Asia, yet (1) the burden of AD/ADRD is rapidly increasing in low- and middle-inc…
Posted May 21, 2026
Building Research Infrastructure for Alzheimer's Disease and Related Dementias in Cote d'Ivoire
US National Institute on Aging · grant
PROJECT SUMMARY Most research on Alzheimer’s Disease and Alzheimer’s-Related Dementias (AD/ADRD) is set in higher income contexts in North America, Europe, and Asia, yet (1) the burden of AD/ADRD is rapidly increasing in low- and middle-inc…
Posted May 21, 2026
Treatment and prevention of osteoarthritis with an intra-articular disease-modifying regenerative therapy
US · IL NIH-NIAMS · NAICS 325412 · small business · grant
Abstract Osteoarthritis (OA), a degenerative joint disorder, affects nearly 10% of the US population. Costs—including loss of work, medications, hospitalization for joint replacement and/or repair surgery, and other types of therapy—are hig…
Posted May 21, 2026
Transposon control as a checkpoint during regeneration
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Tissue regeneration is the process through which damaged tissue is restored to its original structure and function. There is wide variation across species in their regenerative ability. For example, zebrafish can…
Posted May 21, 2026
Using Glycomic Signatures to Monitor Disease Progression and Predict Treatment Response in Lupus Nephritis
US · IL NIH · NAICS 541714 · grant
Abstract Systemic lupus erythematosus (SLE) is one of the most common autoimmune disorders, predominantly affecting women of childbearing age. Up to half of all lupus patients develop lupus nephritis (LN), a severe kidney disease characteri…
Posted May 21, 2026
Pilot Testing Implementation of Suicide Risk Prediction Algorithms to Support Suicide Prevention in Primary Care
US National Institute of Mental Health · grant
PROJECT SUMMARY In 2020, suicide was among the top three causes of death for adolescents and young adults (age 10-34) and among the top nine for adults (age 35-64). Recently, researchers have successfully developed suicide risk prediction a…
Posted May 21, 2026
The TRANS-SAFE Patient Safety Learning Lab: Systems Improvement for Psychosocial Safety in Transgender Care
US · IL Agency for Healthcare Research and Quality (AHRQ) · grant
This patient safety learning laboratory (PSLL) will address the intersection of two major gaps in the science of patient safety: 1) psychosocial patient harm / avoidable patient suffering, and 2) patient safety for transgender individuals. …
Posted May 21, 2026
RFA-DP-24-031: Longitudinal Follow-up of a Nationwide Multiethnic Cohort of Veterans and Non-Veterans with Interstitial Cystitis
US · IL NIH RePORTER · grant
ABSTRACT Interstitial cystitis/bladder pain syndrome (IC) is characterized by pain related to the bladder, usually with frequency and urgency, in the absence of other diseases that could cause these symptoms. Given the difficulty in diagnos…
Posted May 21, 2026
Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responses
US National Eye Institute · grant
In the mammalian sensory cortex, hierarchically-organized areas are reciprocally connected via feedforward (FF) and feedback (FB) circuits. FF connections generate the more complex response properties of neurons in higher areas within paral…
Posted May 21, 2026
Connectivity and function of inhibitory neurons in the primate visual cortex
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY In the mammalian neocortex, cortical computations result from the activity of neural circuits composed mainly of glutamatergic excitatory and GABAergic inhibitory neurons (INs). INs profoundly influence cortical computations…
Posted May 21, 2026
Medical Student Research Program (MSRP) in Eye Health and Disease
US · UT National Eye Institute (NEI) / NIH · grant
To meet the healthcare challenges on which the NEI focuses, it is essential that we nurture and build the physician-scientist workforce, preparing medical students from all areas of the US to become tomorrow’s researchers. Over the past thr…
Posted May 21, 2026
Project 2: Cellular topography and function of the breast cancer tissue microenvironment
US · IL NIH · grant
Abstract/Project Summary Breast cancer (BC) metastasis is an emergent feature that occurs when the tumor’s ability to recruit metabolic resources, avoid immune activation, and disseminate to distant sites exceeds the capacity of surrounding…
Posted May 21, 2026
Machine Learning Prediction of Persistent Adverse Mental Health Outcomes for Autistic Children: Leveraging Social Determinants of Health from Clinical Data
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Autistic children and youth have high utilization of emergency department visits and inpatient stays for psychiatric indication. There is a need to understand who is at the greatest risk for adverse mental health ou…
Posted May 21, 2026
Characterizing gastrointestinal disorder trajectories for autistic sub-groups: Machine learning prediction of risk profiles and response to treatment
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Gastrointestinal (GI) problems are one of the most common concerns reported by families of autistic children and youth and can have significant lifelong impacts on health, quality of life, and participation. Existin…
Posted May 21, 2026
Immunometabolic signatures of BCG-induced neonatal trained immunity
US · MA · Boston NIH · grant
Project Summary/Abstract This proposal presents a 5-year research career development program focused on the study of Bacille Calmette- Guérin (BCG) vaccine and the mechanisms of innate immune memory, otherwise known as trained immunity, und…
Posted May 21, 2026
Optimizing methotrexate use for the management of chronic pediatric non-infectious uveitis
US · IL National Institutes of Health (NIH) · NAICS 541714 · grant
PROJECT SUMMARY Pediatric chronic non-infectious uveitis (NIU) is an inflammatory ocular disease that has a substantial risk for sight-threatening complications. Methotrexate (MTX) is the preferred first line systemic treatment for all subt…
Posted May 21, 2026