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Showing 25 / 21760 · page 26/871
Deciphering the Molecular Puzzle: IMP1 Modulation of Mucus Integrity in Necrotizing Enterocolitis
US · IL NIH · grant
SUMMARY Necrotizing enterocolitis (NEC) is a devastating inflammatory disease that affects the intestines of premature infants. There is a major gap in our understanding of the factors that contribute to the pathophysiology of NEC, includin…
Posted May 21, 2026
Caregiver Cry Perception and Developmental Trajectories of Infant-Caregiver Interactions Involving Cry as an Early Marker of Autism
US National Institute of Mental Health · grant
Project Summary Caregivers of children with autism spectrum disorders often recall differences in their children as early as infancy, despite most children with autism being diagnosed after age 3. Caregiver recall of behavioral differences …
Posted May 21, 2026
Perinatal PFAS Impact Children's Development: Examining the Roles of Placental Functional Multiomics and Protection by Maternal Exercise
US · IL NIH · grant
PROJECT SUMMARY The perinatal period is well-recognized as a critical developmental window where organ systems are rapidly growing and tuning their functional programs. This is also a time when environmental exposures can have profound and …
Posted May 21, 2026
Structural Studies of a T cell Specific Tyrosine Kinase
US · IL NIH · grant
Project Summary T cell development, activation, and differentiation are all dependent on TCR signaling, along with important contributions from costimulatory and cytokine receptor pathways. Many lines of evidence indicate that variations in…
Posted May 21, 2026
Understanding the Role and Regulation of Epithelial Ketogenesis in the Colon
US · IL NIH · grant
Abstract Intestinal stem cells (ISCs) play pivotal roles in intestinal epithelium renewal during homeostasis and after injury. The metabolic demands faced by ISCs require high mitochondrial oxidative phosphorylation (OXPHOS) activity compar…
Posted May 21, 2026
Investigating the Ferrostatic Role of Adipose Tissue Macrophages
US · MA National Institutes of Health · grant
PROJECT SUMMARY Iron is a micronutrient that is essential for nearly every living organism, and maintaining its homeostasis therefore represents a crucial biological problem across all scales: from cells, to tissues, to the whole organism.…
Posted May 21, 2026
The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk
US · IL NIH · grant
Anxiety and its disorders are a risk factor for several major diseases of aging including cardiovascular and auto- immune diseases, Alzheimer's Disease and related dementias (ADRD). As anxiety disorders have the highest lifetime prevalence …
Posted May 21, 2026
Ph1/2 Study of the Imipridone ONC201 for Treatment of AML IND125,203 (12/23/2014)
US Food and Drug Administration · grant
Project Summary/Abstract Survival rates (app. 30 %) of acute myeloid leukemia (AML) have not been improved over 4 decades, except in some specialized instances. The long term aim of this study is to increase the cure rates of AML through cl…
Posted May 21, 2026
Transcriptional regulation of mammary gland development
US · IL Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Mammary gland development and function requires precise stage and spatial control of transcriptional programs. These processes are tightly controlled to ensure the successful function of the mammary gland, including lactation which is essen…
Posted May 21, 2026
Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling
US · IL NIH · grant
Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling Project Summary Aging is characterized by the development of maladaptive immune responses that promote cognitive decline and Alzheimer’s disea…
Posted May 21, 2026
The role of peripheral versus brain myeloid immunity in the cognitive decline of aging and Alzheimer's disease
US · IL NIH · grant
The role of peripheral versus brain myeloid immunity in cognitive decline of aging and Alzheimer’s disease Aging is characterized by the development of detrimental immune responses, where sustained pro-inflammatory responses promote end-org…
Posted May 21, 2026
Reprogramming myeloid cell metabolism to prevent cognitive aging and Alzheimer's Disease
US · IL NIH · grant
REPROGRAMMING MYELOID CELL METABOLISM TO PREVENT COGNITIVE AGING AND ALZHEIMER’S DISEASE SUMMARY The brain is highly vulnerable to aging, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer’s disease (A…
Posted May 21, 2026
Influence of the Menopausal Transition and Lifetime Ovarian Exposure on Neural Metabolism, Connectivity and Pathology
US · IL NIH · grant
Women are significantly more likely to develop Alzheimer’s disease than men, making up 2/3 of all AD cases. Growing evidence suggests that this difference is related to the decline in ovarian hormone levels experienced by women at midlife t…
Posted May 21, 2026
L-Rha and L-Rha Derivatives and Their Effects on Neurodegenerative Alzheimer's Disease
US National Institute on Aging · grant
Project Summary A rare sugar, L-rhamnose (L-Rha) and L-Rha-containing molecules demonstrated unique effects on Alzheimer’s disease (AD). Despite its importance in human health, it is still not clear how L-Rha plays a role in activation of t…
Posted May 21, 2026
Investigation of the effects of interleukin-10 shear thinning hydrogel on human oligodendrocyte progenitor cell survival and differentiation following transplantation
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Some of the most devastating neurodegenerative diseases such as multiple sclerosis, are characterized by chronic demyelination and a tissue environment that prevents efficient myelin repair and remyelination. While cell therapies h…
Posted May 21, 2026
Programmable Hydrogels for Optimized Human Oligodendrocyte Transplantation in Demyelinating Disease
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Some of the most devastating neurodegenerative diseases such as multiple sclerosis, are characterized by chronic demyelination and a tissue environment that prevents efficient myelin repair and remyelination. While cell therapies h…
Posted May 21, 2026
Evaluating a Multilevel Communication Campaign to Increase HIV Vaccine Trial Enrollment
US · IL National Institutes of Health (NIH) · NAICS 541715, 541810, 541820 · grant
Project Summary/Abstract The HIV Vaccine Trials Network (HVTN) has experienced significant challenges recruiting participants in early-stage HIV vaccine clinical trials. Formidable barriers to participation in HVTN preventive HIV early phas…
Posted May 21, 2026
Evaluating state policies to facilitate emergency department-based treatment initiation for opioid use disorder
US · IL NIH · NAICS 541720 · grant
Opioid use disorder (OUD) is a life-threatening health condition affecting 7.6 million people in the U.S. Medications for opioid use disorder (MOUD), such as methadone and buprenorphine, decrease mortality among patients with OUD by 50%. Em…
Posted May 21, 2026
Izumo1 in remission in SLE
US · IL NIH RePORTER · grant
PROJECT SUMMARY/ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of variable severity and course. The disease is characterized by a tendency for flares, in which symptoms get worse, followed by periods of quiescen…
Posted May 21, 2026
The role of cytotoxic T cells in rheumatoid arthritis pathogenesis
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY/ABSTRACT Significant data implicate a role for autoantibodies to citrullinated proteins in RA pathogenesis, and autoantibodies to the citrullinating enzyme peptidylarginine deiminase 4 (PAD4) are also found in a subset of pa…
Posted May 21, 2026
Insights into the origin of ACPAs in RA
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Citrullination is a physiologic post-translational modification found across multiple normal human tissues. Why this modification is the most important target of antibodies in rheumatoid arthritis (RA) is unknown. W…
Posted May 21, 2026
The antigenic origin of anti-dsDNA antibodies in SLE
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT Anti-dsDNA antibodies are serological hallmarks of systemic lupus erythematosus (SLE), and key markers for diagnosis and disease activity. The close association of anti-dsDNA antibodies with SLE has suggested that u…
Posted May 21, 2026
CaV2.2 splice variants in the hippocampus: function and pharmacology
US National Institute of Mental Health · grant
The effects of cannabinoids are diverse and dose dependent. For instance, low doses produce anxiolysis whereas high doses induce anxiety; similar effects have been seen on memory and cognition. However, the reasons for this are not clear. A…
Posted May 21, 2026
SULT4a1, a novel neuroprotective protein in stroke
US · IL NIH · grant
Stroke remains a leading cause of death and morbidity in the USA and lacks effective therapeutic interventions. Redox imbalance and mitochondrial dysfunction are considered as leading causes of cell death in stroke. Identification of novel …
Posted May 21, 2026
B cell lineage directed rational vaccine strategies based on CAP256SU Env-Ab coevolution
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT: The development of an effective HIV vaccine remains a major challenge. Previous strategies for HIV vaccine design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutralizing antib…
Posted May 21, 2026