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Showing 25 / 21760 · page 33/871
Alzheimer Disease Progression, Host Gut Microbiome, and Enteric Dysfunction
US · IL NIH · grant
Project 3: Project Summary/Abstract The gut microbiome (GM) is comprised of thousands of microbial taxa, with a vast repertoire of functional pathways that interact with the host environment. Dysbiosis of the GM is associated with numerous …
Posted May 21, 2026
Clinical Science Core
US National Institute of Allergy and Infectious Diseases · grant
Modified Clinical Science Core Project Summary/Abstract Section The Midwest D-CFAR Clinical Science Core (CSC) is committed to addressing the persistent clinical challenges posed by HIV and its related conditions. Despite significant progr…
Posted May 21, 2026
THE NIH NATIONAL NEUROHIV TISSUE CONSORTIUM (NNTC) - NEW CLINICAL SITE
US · IL NIH · grant
The purpose of this contract is to establish a new National NeuroHIV Tissue Consortium (NNTC) Clinical site as a critical resource for catalyzing high priority research in NeuroHIV (CNS complications in people with HIV), including studies t…
Posted May 21, 2026
Project 1: Biomarkers for Characterizing and Predicting AD in DS
US National Institute on Aging · grant
Project 1 Abstract An overarching theme of the Alzheimer's Disease Biomarkers-Down syndrome (ABC-DS) program is to characterize Alzheimer disease (AD) in Down syndrome (DS) and to determine if it has a pathological progression comparable to…
Posted May 21, 2026
THE ADMINISTRATION CORE (AC)
US NIH · grant
ABSTRACT FOR ADMINISTRATIVE CORE The Administrative Core (AC) will support the overall work of the Aging Adult Brain Connectome (AABC) to establish a focused program that identifies salient variables that affect the trajectory of brain str…
Posted May 21, 2026
Identifying neural circuits that support effortful listening
US National Institute on Deafness and Other Communication Disorders · grant
Project Summary/Abstract Candidate: My long-term career goal is to establish an independent research program focusing on the neural mechanisms of listening effort, and explore how adolescent hearing loss alters this mechanism. My previous t…
Posted May 21, 2026
The neural foundations of regulation in infancy and the role of individual and environmental factors over time
US · IL NIH · grant
Project Summary/Abstract The neural mechanisms of regulation support socioemotional competence 63,74 and may operate as resilience factors in the face of developmental risk for psychopathology 13,17. Investigating how these neural mechanis…
Posted May 21, 2026
Endoplasmic Reticulum (ER)-phagy in Influenza Infection
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Influenza infection in susceptible patients results in a higher viral load, cytokine storm, tissue damage, lung function decline, and mortality. It is well known that interferons control influenza burden and inflammatory res…
Posted May 21, 2026
ERC Einstein Rockefeller CUNY Center for AIDS Research
US · NY · New York City NIH · grant
PROJECT SUMMARY ERC-CFAR: CLINICAL AND TRANSLATIONAL SCIENCE CORE (CTSC) To help meet the vision of Ending the HIV Epidemic (EHE), the Einstein-Rockefeller-CUNY Center for AIDS Research (ERC-CFAR) has formed strong collaborations both withi…
Posted May 21, 2026
Development of functional plasticity in a simplex retina.
US National Eye Institute · grant
PROJECT SUMMARY/ABSTRACT: Retinal sensitivity over the full range of environmental lighting conditions, from dark to bright, is mediated by rod and cone photoreceptors and is fundamental to vision. Importantly, when one type of photorecepto…
Posted May 21, 2026
Towards a biophysical model of human cortical neurophysiological signatures that incorporates cellular and cell type biophysics, transcriptomics, and morphology
US · IL National Institutes of Health (NIH) · grant
Project Summary The past decade has seen an unprecedented accumulation of data at the single-cell level giving rise to unique, multimodal sets of gene expression patterns, morphologies, and electrophysiology characteristics. This high- reso…
Posted May 21, 2026
A Computational Framework Enabling Virtual Imaging Trials of 3D Quantitative Optoacoustic Tomography Breast Imaging
US · IL NIH · grant
ABSTRACT Optoacoustic tomography (OAT), also known as photoacoustic computed tomography, is a non-invasive imaging modality actively being developed for breast cancer imaging and other biomedical applications. A unique feature of OAT is the…
Posted May 21, 2026
Computational imaging and intelligent specificity (Anastasio)
US · IL NIH RePORTER · grant
SUMMARY In this technology research and development (TRD) project, advanced computational and machine learning methods will be developed that address a variety of needs related to image formation and image analysis in high-resolution label-…
Posted May 21, 2026
Deep learning technologies for estimating the optimal task performance of medical imaging systems
US National Institute of Biomedical Imaging and Bioengineering · grant
ABSTRACT Modern medical imaging systems comprise complicated hardware and sophisticated computational methods. Given the sheer number of system parameters that impact image quality, the large variety in objects to be imaged, and ethical con…
Posted May 21, 2026
Developing Human Induced Pluripotent Stem Cell Precision Oncology Models
US National Cancer Institute · grant
Abstract This proposal was specifically designed to support a dedicated Research Specialist with extensive experience in human induced pluripotent stem cell (hiPSC) engineering to study the cellular and molecular mechanisms underlying the f…
Posted May 21, 2026
Mechanisms of Pol II Elongation in Diffuse Midline Glioma
US · IL NIH · NAICS 541714 · grant
Project Summary/Abstract Diffuse midline gliomas (DMGs) are aggressive brain tumors in both children and adults with no effective therapies. Over 80% of pediatric DMG and a majority of adult DMG harbor non-synonymous mutations in histone H3…
Posted May 21, 2026
Making women's options for HIV prevention in Tanzania accessible and joining implementation science capacity building (MWOTAJI)
US · IL NIH · NAICS 541720 · grant
SUMMARY Adolescent girls and young women (AGYW; ages 15-24) in sub-Saharan Africa face a disproportionate burden of HIV infection. Though highly effective HIV prevention like pre-exposure prophylaxis (PrEP) is central to the global strategy…
Posted May 21, 2026
COMPUTATIONAL FRAMEWORKS FOR PHAGE DISCOVERY, ECOLOGY, AND DYNAMICS FROM METAGENOMES
US National Institute of General Medical Sciences · grant
Project Summary/Abstract Metagenomics sequencing is increasingly becoming important for human microbiome research. Human microbiomes comprise a rich ecosystem of beneficial and pathogenic microorganisms and bacteriophages that can influence…
Posted May 21, 2026
Pre and post-synaptic pathways underlying the stress response in the adrenal medulla
US · IL NIH · grant
ABSTRACT The “fight-or-flight” response refers to the state of heightened physiological and mental arousal triggered by a physical threat, emotionally charged event, or metabolic disturbance. Although the precise reaction to each stressor m…
Posted May 21, 2026
Determinants of inception of inflammation in inflammatory bowel diseases
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary Crohn’s disease (CD) and ulcerative colitis (UC) affect over 2 million individuals in the United States and are associated with considerable morbidity. Existing treatments achieve remission in fewer than 50% of patients. Fur…
Posted May 21, 2026
The Pediatric Advanced Cancer Experience (PACE): Measuring Quality of End-of-Life Care for Children with Cancer
US · IL NIH · grant
PROJECT SUMMARY Although cure rates for childhood cancer have increased over several decades, cancer remains the leading cause of non-accidental death in children. Yet, there are no existing quality measures to define optimal end-of- life c…
Posted May 21, 2026
Quantum Dynamic Investigations of Redox in Biology
US · IL NIH RePORTER · grant
Project Summary Establishing a fundamental understanding of redox processes in biology is a key challenge with the potential to transform research in areas ranging from the development of biomimetic materials for efficient energy harvestin…
Posted May 21, 2026
Molecular Determinants of Age-Related Cognitive Decline in the Basal Forebrain to Lateral Entorhinal Cortex Circuit
US National Institute on Aging · grant
PROJECT SUMMARY The entorhinal cortex (EC) is a critical mediator of cortico-hippocampal communication and thus essential for memory. Numerous studies identify the EC as the first brain region to display age-related changes such as accumula…
Posted May 21, 2026
Ambient Air Pollution, Weather, and Placental Abruption (APWA)
US National Institute of Environmental Health Sciences · grant
ABSTRACT Placental abruption results in hemorrhage, ischemia, and fetal hypoxia, placing a tremendous health burden on both the mother and the newborn. Efforts to understand the etiology of this devastating obstetrical complication have bee…
Posted May 21, 2026
The Effectiveness of Automated Multimodal Imaging in High Grade Squamous Intraepithelial Lesions (HSIL) Diagnosis for People Living with HIV: An International Trial
US · IL NIH · NAICS 541715 · grant
Abstract: Squamous cell cancer of the anus (SCCA) is increasing in the aging cohort of people living with HIV (PWH), who are at 40-80x higher risk for SCCA than the general population. The increase in invasive anal cancer, and its precursor…
Posted May 21, 2026