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Showing 25 / 21760 · page 54/871
Targeted drug delivery system to overcome blood-brain barrier and therapeutic resistance to current standard of care in Glioblastoma
US National Cancer Institute · grant
Project Summary/Abstract: The uniform lethality of glioblastoma (GBM) with a survival of less than 2 years despite best available therapy is attributed to treatment resistance due to DNA repair mechanisms that drive disease relapse and tumo…
Posted May 21, 2026
Xavier University of Louisiana-Mobile Outreach for Laboratory Enrichment (XULA-MOLE)
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY The application for Xavier University of Louisiana's Mobile Outreach for Laboratory Enrichment (XULA- MOLE) proposes a comprehensive training and mentoring program for high school students and teachers. This project is a par…
Posted May 21, 2026
Engineering a Novel Bio-Scaffold for Hepatic Tissue Restoration and Drug Screening
US National Institute of General Medical Sciences · grant
Health issues associated with liver diseases afflict millions of individuals and account for over 70,000 deaths annually in the United States. Due in part to an aging population, liver diseases are expected to rise significantly over the ne…
Posted May 21, 2026
Role of a novel human mast cell G protein coupled receptor in Allergy and Inflammation
US National Institute of Allergy and Infectious Diseases · grant
Summary: Mast cells (MCs) are best known for their roles in IgE-mediated allergic disorders. However, the recent identification of Mas-related G protein coupled receptor-X2 (MRGPRX2) in human cutaneous MCs (MrgprB2; mouse counterpart) as t…
Posted May 21, 2026
Roles of novel MRGPRX2/MrgprB2 signaling in mast cells on host defense and Inflammation
US National Institute of Allergy and Infectious Diseases · grant
Summary: Mast cells (MCs) are tissue-resident immune cells that are best known for mediating IgE/FcεRI-mediated hypersensitivity and atopic disorders. However, recent excitement in MC research has been the realization that a diverse group o…
Posted May 21, 2026
Mast Cell G-protein Coupled Receptors in Immune Modulation of colitis
US National Institute of Allergy and Infectious Diseases · grant
Summary: Ulcerative colitis (UC) is a subtype of inflammatory bowel disease with symptoms of abdominal pain and bloody diarrhea secondary to colonic inflammation. Human colonic mast cells (MCs) express a novel G protein-coupled receptor kn…
Posted May 21, 2026
Mechanisms of Gait and Balance Impairment in Progressive Supranuclear Palsy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Progressive supranuclear palsy (PSP) is a fatal, progressive, incurable neurodegenerative tauopathy. Falls resulting from gait and balance impairments are a cardinal feature of the disease and occur in all PSP syndr…
Posted May 21, 2026
Regulation of one-carbon metabolism and purine synthesis by YRDC in hepatocellular carcinoma
US National Institute of General Medical Sciences · grant
Hepatocellular carcinoma (HCC) accounts for >80% of patients with liver cancer and is one of the leading causes of cancer-associated mortalities, both worldwide and in the United States. Recent evidence highlights the involvement of YRDC (Y…
Posted May 21, 2026
2/3 Akili: Phenotypic and genetic characterization of ADHD in Kenya and South Africa
US National Institute of Mental Health · grant
PROJECT SUMMARY ADHD is a common neurodevelopmental disorder that includes attention difficulty, impulsivity, and hyperactivity. The diagnosis is associated with many challenges to educational, occupational, and health outcomes, particularl…
Posted May 21, 2026
UZIMA-DS: UtiliZing health Information for Meaningful Impact in East Africa through Data Science
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
PROJECT SUMMARY – Overall Component Africa is the youngest continent in the world, with 60% of its population under the age of 25. The span between early life to young adulthood represents a critical window where biological, environment and…
Posted May 21, 2026
Psychosocial stress and its relation to maternal and infant outcomes among women with disabilities
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Women with disabilities are increasingly becoming pregnant, and may be as likely to become pregnant as women without disabilities. Growing research suggests pregnancy in women with disability is associated with an increased risk for adverse…
Posted May 21, 2026
A novel drug delivery system for the prevention and rescue of fentanyl and other opioid overdoses
US National Institute on Drug Abuse · grant
Opioids have significant adverse effects highlighted by the large number of patients with opioid use disorder (OUD) and the increasing number of overdose deaths in the United States and elsewhere. In just the 12-month period ending in Novem…
Posted May 21, 2026
Unraveling the homeostatic and hedonic circuits underlying feeding behavior and obesity
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY The striking prevalence of obesity and its associated personal and public health consequences highlights the importance of understanding why individuals overeat and gain weight. It is widely recognized that overeating result…
Posted May 21, 2026
Unraveling the neural mechanisms for satiety and weight loss by GLP1-based drugs
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Over the last several decades, obesity rates have been rising, and research has failed to solve this public health crisis. Now, we are at the precipice of change. Glucagon-like peptide-1 (GLP1)-based obesity drugs have emerg…
Posted May 21, 2026
The role of T cell derived cytokines in Helicobacter pylori and other gastrointestinal infections.
US Veterans Affairs · grant
Project Summary Background and Innovation. Chronic infections and the inflammation associated with long-term immune activation contribute to carcinogenesis in several tissues, especially gastrointestinal infections. Specifically, Helicobact…
Posted May 21, 2026
"Research Initiative for Scholar Diversity to Uphold Veteran Health"
US Veterans Affairs · grant
Project Summary Creating and supporting a diverse, inclusive workforce leads to increases in productivity and innovation. Further, when providing service to patients, a diverse and inclusive environment provides patients with improved care.…
Posted May 21, 2026
Biomarker Core
US National Institute on Aging · grant
REVISED PROJECT SUMMARY – BIOMARKER CORE The overall goal of the Biomarker Core is to collect, bank, and distribute fluid biospecimens and to generate and share extensive biomarker datasets with the scientific community to address the heter…
Posted May 21, 2026
Intersection of Uremic Toxins and Biological Sex in Chronic Kidney Disease Progression
US National Institute of General Medical Sciences · grant
Children with chronic kidney disease (CKD) are at high risk of complications and have a reduced life expectancy compared to healthy peers. The risk of complications and death increases as CKD progresses to higher stages. Childhood CKD is …
Posted May 21, 2026
Effects of Poly(ethylene glycol) Immunogenicity on Implant Biocompatibility
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Poly(ethylene glycol) (PEG) based hydrogels are widely used in medical devices and are being studied for the delivery of protein and cellular therapeutics. While these biomaterials are widely regarded as biologically inert, …
Posted May 21, 2026
Addressing negative social experiences through coping and resilience to reduce methamphetamine use and improve PrEP cascade progression among Latino MSM
US National Institute on Drug Abuse · grant
Negative social experiences are a main driver of HIV disparities among Latino men who have sex with men (LMSM), negatively affecting non-injection substance use (e.g. methamphetamine) and PrEP uptake. Addressing factors that influence PrEP …
Posted May 21, 2026
Understanding the relationship between cortical hyperexcitability and the progression of FTD/ALS pathology and behavioral deficits in mice
US National Institute on Aging · grant
Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder that causes severe personality and behavior changes. A hexanucleotide repeat expansion in the C9orf72 gene is FTD's most common genetic cause. I aim to elucidate the …
Posted May 21, 2026
High-Throughput In Vitro Analyses of Trauma-Induced Tauopathy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repeated mild traumatic brain injury (TBI). CTE is among the many neurodegenerative diseases characterized as tauopathies, wherein the pro…
Posted May 21, 2026
Role of mechanical heterogeneity in cerebral aneurysm growth and rupture
US National Institute of Neurological Disorders and Stroke · grant
Cerebral aneurysms (CAs) are out-pouching dilations of cerebral arteries caused by local wall weakening and maladaptive remodeling. Though rupture is relatively rare, the post-rupture survival rate is low, due to complications such as vasos…
Posted May 21, 2026
SBIR TOPIC 111, PHASE II: A COMPACT PORTABLE MEDICAL OXYGEN GENERATOR
US National Heart Lung and Blood Institute · grant
NHLBI has developed the Myocardial Intramural Restraint by endovenous interstitial teTHer (MIRTH) procedure and the related Suture via Coronary sinus with Interstitial myocardial navigation for MItral and Tricuspid Annular Reduction (SCIMIT…
Posted May 21, 2026
Unlocking New Chemistries in Extant Enzymes for Synthesizing Bioactive Molecules
US National Institute of General Medical Sciences · grant
Project Summary/Abstract: Enzymes, supported by their macromolecular structure, can catalyze chemical transformations with exquisite control, delivering products with high selectivity. The mechanisms that enzymes can support, however, are l…
Posted May 21, 2026