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Showing 25 / 21760 · page 13/871
Impact of Metals on Biological Aging and Cardiometabolic Traits in Adolescents
US · IL NIH · grant
ABSTRACT The ubiquitous presence of toxic metal exposures in the environment is a global public health concern, with disadvantaged populations disproportionately exposed and susceptible to adverse effects. Lead, arsenic, cadmium, and mercur…
Posted May 21, 2026
ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders
US National Institute of Neurological Disorders and Stroke · grant
Abstract: The corpus callosum – the largest fiber tract in the human brain, connects and integrates the two cerebral hemispheres. Agenesis of the corpus callosum (ACC) with an incidence of 1 in 2,000 occurs in rare syndromes and in common n…
Posted May 21, 2026
Disparities in the burden and progression of multi-morbidity across adulthood
US · IL NIH · grant
PROJECT SUMMARY RELEVANCE: Approximately 1 in 4 U.S. adults suffers from multimorbidity, or two or more concurrent chronic diseases. People with multimorbidity experience more disability and higher mortality risk and have higher medical cos…
Posted May 21, 2026
Using high T-bet-expressing cells and Serum Chemokines as Indicators of Disease Severity in Sarcoidosis
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects multiple organs, especially the lungs. It has a wide range of clinical outcomes, including progressive lung disease and multi-organ in…
Posted May 21, 2026
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER
US National Heart Lung and Blood Institute · grant
The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infar…
Posted May 21, 2026
Core F: Biomarker/Neuroimaging Core
US National Institute on Aging · grant
ABSTRACT – BIOMARKER/NEUROIMAGING CORE The overall goal of the proposed Biomarker/Neuroimaging Core in the Rush Alzheimer’s Disease Research Center (Rush ADRC) is to build a resource of neuroimaging data on participants of the Rush ADRC and…
Posted May 21, 2026
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementia
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Cerebral small vessel disease (SVD) encompasses a range of common processes and pathologies (arteriolosclerosis, cerebral amyloid angiopathy, small vessel atherosclerosis, small and microscopic infarcts and bleeds, enlarged perivas…
Posted May 21, 2026
Uncovering brain-wide molecular determinants of individual memory performance across lifespan
US · IL NIH · grant
Project Summary One of the most crucial functions of an organism's nervous system is the ability to form long-term memories. However, the molecular mechanisms underlying long-term memory formation have yet to be fully elucidated, due to the…
Posted May 21, 2026
High salt-dependent regulation of the Na+/K+/2Cl- co-transporter (NKCC2) ubiquitination by E3-ubiquitin ligases in Thick Ascending Limb
US · IL NIH RePORTER · NAICS 541715 · grant
HYPERTENSION is considered the leading cause of “loss of health” worldwide, involving the kidney’s inability to excrete excess salt. During high salt intake the kidneys excrete the extra salt load by increasing the blood pressure, phenomeno…
Posted May 21, 2026
Structure, regulation, and evolution of the splicing machinery
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY The complexity of human splicing is daunting, yet intervention in splicing for treatment of diseases holds huge potential. Based on strong preliminary results, we propose three areas of investigation that leverage our group…
Posted May 21, 2026
Hematology & Transfusion Medicine
US · IL NIH · grant
The Hematology and Transfusion MedicineT32 Training Program at Duke, first established by Dr. Wendell Rosse in 1976, remains a vibrant program for developing scientific leaders in hematology and transfusion medicine. Historically, our progr…
Posted May 21, 2026
Complement and thrombosis in HIT
US · IL NIH · grant
ABSTRACT Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder caused by ultra-large immune complexes (ULICs) composed of IgG antibodies (Abs) to platelet factor 4 (PF4) and heparin (H). Even with prompt recognition, discontinuati…
Posted May 21, 2026
A CHOLINERGIC NEUROCIRCUIT REGULATES FEEDING BEHAVIOR
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Obesity is a major risk factor for many chronic medical conditions, including diabetes, cardiovascular disease, depression, and cancer. Elucidating the neural networks that regulate feeding behavior and body weight control i…
Posted May 21, 2026
Genetically Dissecting Cholinergic Signaling in Body Weight Control
US · IL NIH · NAICS 541714 · grant
Abstract / Project Summary Obesity-associated diseases such as diabetes and cardiovascular disease together account for the leading cause of death in the United States. Roughly one-third of the U.S. population is obese, and it is estimated …
Posted May 21, 2026
Neuroendocrine Core
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
SUMMARY – NEUROENDOCRINE CORE The Neuroendocrine Core will allow nutrition or obesity researchers to gain easy access to cutting-edge neuroscience techniques to measure, monitor, and manipulate the neuroendocrine system in rodent models. T…
Posted May 21, 2026
Consequence of human satellite repeat expression and immunostimulatory potential in FSHD
US · IL National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY Facioscapulohumeral muscular dystrophy (FSHD) is the third most common form of muscular dystrophy that is caused by mis-expression of an early embryonic transcription factor DUX4 in skeletal muscle. DUX4 induces an early emb…
Posted May 21, 2026
SEER RESEARCH SUPPORT REGISTRIES PROGRAM LINKAGES AND DATA MANAGEMENT SUPPORT
US · IL NIH · grant
The SEER Research Support Registries Program Linkages and Data Management Support project is designated to increase the research value of the SEER data, with a special emphasis on the National Childhood Cancer Registry (NCCR) program to enh…
Posted May 21, 2026
Perceptual implications of cochlear implant electrode-neuron interfaces
US · IL NIH · NAICS 541715 · grant
Project Summary/Abstract Cochlear implants are highly successful neural prostheses that enhance or restore audition to severely hearing-impaired adults and children. Sound from the environment is converted into electrical pulses and convey…
Posted May 21, 2026
Improving Cochlear Implant Outcomes Through Modeling and Programming Strategies Based on Human Inner Ear Pathology
US National Institute on Deafness and Other Communication Disorders · grant
Project Summary/Abstract Cochlear implants are highly successful neural prostheses that enhance or restore hearing to severely hearing-impaired adults and children. Sound from the environment is converted into electrical pulses and conveye…
Posted May 21, 2026
Investigating the role of Wnt signaling effectors on the neuron-glia switch and OPC specification during development and after injury.
US · IL NIH · grant
PROJECT SUMMARY Nervous system development and regeneration relies on sequential and coordinated formation of diverse neurons and glia from neural progenitor cells. Though neuronal and glial differentiation is extensively studied, less is k…
Posted May 21, 2026
DP21-003 Scaling Social Determinants of Health Screening, Social Support and Anti-Racism Training to Reduce Inequities in Minority Cancer Survivor Health and Wellbeing in Washington, DC
US National Center for Chronic Disease Prev and Health Promo · grant
SUMMARY Despite improvements in cancer outcomes over time, significant disparities remain between Black and White cancer survivors. Social determinants of health (SDOH) explain up to 80% of health outcomes while clinical care is estimated t…
Posted May 21, 2026
Practical delivery of geriatric assessment in community oncology settings
US · IL NIH · grant
Older adults will constitute 75% of the projected 22.2 million US cancer survivors by 2030, with the largest growth among older survivors (age 65 and up). This older population is at higher risk of adverse events due to cancer treatment, bu…
Posted May 21, 2026
Enhancing Editing Efficiency, Versatility and Guide Design of CHyMErA Screening Platform
US · IL NIH · grant
We have successfully developed a suite of cell lines expressing diverse Cas12a variants and conducted comprehensive functional screening using our Cas9-Cas12a CHyMErA platform, in conjunction with an optimized hgRNA library. These screens i…
Posted May 21, 2026
Establishing Combinatorial Screening Platform Coupled to Single-cell Analysis
US · IL NIH · grant
By optimizing the hgRNA scaffold sequence and refining library preparation protocols, we have significantly enhanced the CHyMErA exon deletion screening platform for single-cell experiments. This advanced tool enables efficient combinatoria…
Posted May 21, 2026
Unravelling Metabolic Plasticity Through Genetic Interaction Mapping.
US National Cancer Institute · grant
We use our CHyMErA CRISPR screening platform for the mapping of GIs through acute, combinatorial gene perturbation. We designed a GI library targeting genes involved in central metabolism and its regulation, enabling the experimental interr…
Posted May 21, 2026