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Showing 25 / 21760 · page 22/871
mitochondrial DNA leakage promotes inflammation and intervertebral disc degeneration
US · IL NIH · grant
Intervertebral disc (IVD) degeneration (IDD) is a major cause of low back pain, affecting 39% of American adults over the age of 18 and costing $87.6 billion in estimated healthcare expenditure. IDD is characterized by structural and functi…
Posted May 21, 2026
Oxytocin-mediated calcium signaling in physiologic uterine contractility and uterine atony
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project summary Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Uterine atony, insufficient uterine contractility after placental delivery, causes 80% of PPH. Oxytocin is the medical standard of …
Posted May 21, 2026
A new paradigm of general transcription factor TFIIB functionality in termination and promoter directionality
US National Institute of General Medical Sciences · grant
Project Summary Regulated transcription of genes is essential for cell proliferation, differentiation and viability. Any misregulation may lead to a disease or a developmental abnormality. The transcription cycle of eukaryotic genes consist…
Posted May 21, 2026
The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic Stroke
US · IL NIH · grant
Project Summary/Abstract Stroke is a prevalent and devastating disease with limited therapeutic options. Inflammation and immune cells are major components in the pathophysiology of ischemic stroke and contribute to acute and delayed tissue…
Posted May 21, 2026
Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin
US · IL National Institutes of Health · grant
Why some people develop Multiple Sclerosis and others do not, despite similar genetic risk and quantities of circulating autoreactive lymphocytes, is not known. Our long-term goal is to identify environmental triggers of MS, define the mole…
Posted May 21, 2026
Impact of developmental serotonin on prefrontal cortex parvalbumin interneuron excitability and cognitive behavior
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Sensitive periods are periods during early windows of development in external experiences or exposures can shape patterns of connectivity and behavior later in life. Such periods allow for circuit maturation to ada…
Posted May 21, 2026
ROC StARR: Health and Immune Function Across the Lifespan
US · NY · Rochester NIH · grant
Physician-scientists bring a unique perspective to biomedical research, informing clinically inspired basic science questions (bedside-to-bench), translating fundamental research back to the clinic (bench-to-bedside), and guiding implementa…
Posted May 21, 2026
AIM-for-RA
US · IL NIH · grant
Rheumatoid arthritis (RA) affects approximately 1% of the population and is characterized by inflammation and joint damage, often leading to considerable disability and pain in both early and established stages. Key areas of unmet need in t…
Posted May 21, 2026
Role of T-bet B cells in rheumatoid arthritis
US · IL NIH · grant
Although new treatments have improved outcomes in rheumatoid arthritis (RA), disability remains high, most patients have ongoing disease activity, and lasting remissions are rare. A major gap in the field is the elusive identity of pathogen…
Posted May 21, 2026
Adipose FHL1 in energy homeostasis
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
SUMMARY Tremendous advances have been made in the study of adipose biology but there are gaps in our understanding of adipose development and functions. The long-term goal of our research is to understand how adipose tissues regulate whole-…
Posted May 21, 2026
Neurobehavioral consequences of Mild Traumatic Brain Injury and addiction risk: a cotwin-control study
US National Institute on Drug Abuse · grant
Project Summary/Abstract The overall goal of the proposed study is to identify long-term neurobehavioral consequences of childhood mild traumatic brain injury (mTBI) for the developing brain and examine their contribution to addiction risk …
Posted May 21, 2026
Developing A Platform Technology For β-Cell-Targeted Drug Delivery
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Type 1 diabetes is characterized by the loss of β-cell mass and decreased insulin production capacity. Thus, developing a pharmacologic method for stimulating the expansion of β-cell mass has substantial potential therapeuti…
Posted May 21, 2026
Diabetes, Endocrinology and Metabolism Training Grant
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary The T32 Training Program in Diabetes, Endocrinology and Metabolism at Stanford University (Endocrine T32) serves a national need to train physician and basic scientists in the fields of diabetes, endocrinology and metabolism…
Posted May 21, 2026
Operationalizing wastewater-based surveillance of multidrug-resistant bacteria
US · IL NIH RePORTER · grant
Multidrug-resistant organisms (MDRO) pose a significant risk to public health. Infections with MDRO are associated with high mortality rates and healthcare costs, particularly related to hospital-acquired pneumonia. Current approaches to co…
Posted May 21, 2026
Decoding multidrug-resistant pathogen dynamics for clinically-relevant wastewater surveillance
US · IL NIH · NAICS 541714 · grant
Multidrug-resistant bacteria (MDRB) contribute increasingly to morbidity, mortality, and healthcare costs. Extended-spectrum beta-lactam- and carbapenem-resistant Enterobacterales (ESBL-E and CRE) are MDRB of particular concern due to their…
Posted May 21, 2026
SARS-CoV-2 initiation and acceleration of AD pathology in the setting of endogenous and exogenous risk factors
US National Institute of Neurological Disorders and Stroke · grant
The uncertain etiology of Alzheimer’s disease poses significant obstacles to the development of both therapeutic and prevention strategies. At the root of this quandary is the fact that familial disease accounts for a very small fraction of…
Posted May 21, 2026
Genome-wide approaches to non-invasive screening and characterization of ovarian cancers
US National Cancer Institute · grant
PROJECT SUMMARY Ovarian cancer is the deadliest gynecological cancer, in part because there is no widely used screening test and 80% of tumors are diagnosed at a late stage. Though ovarian cancer screening has the poten>al to diagnose tumor…
Posted May 21, 2026
Engineering biomimetic 3D printed urethral tissue constructs using elastin-based bioinks for urethroplasty
US · IL NIH · grant
Project Summary Urethral defects requiring urethroplasty occur in children and adults secondary to congenital, traumatic, infectious, and malignant conditions. Current tissue sources for urethral replacement are limited by donor site morb…
Posted May 21, 2026
Engineering Tunable Biomimetic Adhesive Hydrogel to Deliver and Enhance MSC Function for Corneal Regeneration
US National Eye Institute · grant
Project Summary Corneal diseases pose a significant public health challenge in the United States, often leading to vision impairment and decreased quality of life. Mesenchymal stem cell (MSC) delivery to the cornea after a severe injury has…
Posted May 21, 2026
Cancer Aging and Metabolism research experience Program (CAMP)
US National Cancer Institute · grant
SUMMARY The Beckman Research Institute of City of Hope (COH) is a world-class cancer research institution and cancer hospital with a mission of turning science into practical benefit through exquisite care, innovative research, and vital ed…
Posted May 21, 2026
Core 1: Planning and Evaluation
US National Cancer Institute · grant
The goals of the Planning and Evaluation Core (PEC) are to monitor, evaluate, and assess the progress of our U54 Partnership in meeting its milestones, objectives, and goals. The PEC supports our University of California, Riverside (UCR)–Ci…
Posted May 21, 2026
Cancer Metabolism Training Program
US National Cancer Institute · grant
PROJECT SUMMARY Links between cancer and metabolic dysfunction were first discovered almost a century ago. Evidence acquired since indicates significant challenges remain in fully delineating those links and exploiting metabolism in the dia…
Posted May 21, 2026
Mechanisms that establish a functional stem cell niche during organogenesis
US National Institute of General Medical Sciences · grant
Project Summary/Abstract: Stem cells are required for tissue homeostasis and regeneration. Accomplishing these tasks requires intimate association with a niche, a cellular microenvironment that forms in a specialized tissue location with pr…
Posted May 21, 2026
Population Data Use and Management Core
US National Institute on Aging · grant
Project Summary/Abstract: POPULATION DATA USE AND MANAGEMENT RESOURCE CORE The Mount Sinai Older American Independence Center (MS-OAIC) aims to improve the independence and quality of life for older adults with serious illness, with a foc…
Posted May 21, 2026
Research Experience and Training Coordination Core
US National Institute of Environmental Health Sciences · grant
SUMMARY/ABSTRACT: Research Experience and Training Coordination Core The Superfund Research Program at the University of Iowa (ISRP) supports investigations of the consequences of sources and exposures to all airborne polychlorinated biphe…
Posted May 21, 2026