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Showing 25 / 21760 · page 40/871
Cardiovascular and neuromuscular issues in chronic pain
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Although chronic pain (CP) affects over 20% of the U.S. population, little is known about associated physiological consequences, which likely contribute to the patients’ functional limitations and high risk for c…
Posted May 21, 2026
Efficacy of exercise training in patients with HFpEF
US Veterans Affairs · grant
ABSTRACT Patients with heart failure with preserved ejection fraction (HFpEF) are characterized by exercise intolerance and premature fatigue during physical activity. An abnormal exercise pressor reflex mediated by neural feedback from me…
Posted May 21, 2026
Interrogating Mechanisms of Anti-tumor Immunity in Human Subjects and Murine Models of IDH-Mutant Glioma Treated with All-Trans Retinoic Acid and PD-1 Inhibition
US National Cancer Institute · grant
Project Abstract Diffuse gliomas are fatal brain tumors that respond poorly to current immunotherapies. Using both mice models and human clinical trial data, we propose a series of experiments to identify immune biomarkers and key immune ce…
Posted May 21, 2026
Cell-Specific Transcriptional Programs in Cardiac Allograft Vasculopathy
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Cardiac allograft vasculopathy (CAV), a form of chronic rejection, is a leading cause of late graft failure and mortality after heart transplantation (HT). It is characterized by diffuse intimal thickening of the en…
Posted May 21, 2026
Prophylactic Immunotherapy for Marburg Virus Disease Outbreak Control
US National Institute of Allergy and Infectious Diseases · grant
The ebolaviruses (EBOV, SUDV, BDBV) and marburgviruses (MARV and RAVV), cause periodic outbreaks of severe viral hemorrhagic fever with very high mortality rates. The 2013-2016 Ebola virus disease (EVD) outbreak in West Africa highlighted t…
Posted May 21, 2026
A multimodal approach for immunotherapy of Staphylococcus aureus bacteremia
US National Institute of Allergy and Infectious Diseases · grant
Staphylococcus aureus (S. aureus; SA) colonizes >50% of people and causes a wide range of diseases including bacteremia, pneumonia, and surgical site infections. No SA vaccines or immunotherapeutics are approved or in late-stage clinical de…
Posted May 21, 2026
Multivalent Toxoid Vaccine for recurrent Staphylococccus aureus disease
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Staphylococcus aureus (S. aureus; SA) is a major public health threat causing a variety of diseases from the skin and soft tissue infections (SSTI), comprising over 90% of infections, to invasive and life-threatening infecti…
Posted May 21, 2026
Monoclonal Antibody Cocktail for Treatment of Marburg Virus Disease
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Ebola (EBOV) and Marburg (MARV) viruses cause hemorrhagic fever disease in humans and nonhuman primates (NHPs) with case-fatality rates as high as 90%. The 2013-2016 Ebola Virus Disease (EVD) outbreak led to over 28,000 case…
Posted May 21, 2026
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural Control
US · IL National Institutes of Health · NAICS 541715 · grant
ABSTRACT (CATALYST PROJECT) While much research has been dedicated to understanding the pathophysiology of Parkinson’s disease (PD), the neural circuit dynamics underlying the manifestation of motor signs remain to be determined. Current th…
Posted May 21, 2026
Characterizing the pathophysiological role of the pallido-thalamocortical motor pathway in Parkinson's disease
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Although studied for decades, the physiological changes in the basal ganglia thalamocortical (BGTC) circuit that underlie the development of motor signs of Parkinson’s disease (PD) remain under debate. Excessive synchronization and…
Posted May 21, 2026
Development of Therapeutic Products for Marburg Virus
US National Institutes of Health · grant
To support the advanced development of a promising candidate therapeutic for NIAID Category A, B, and C Priority Pathogens or emerging infectious diseases. The research and development activities to be supported will allow the candidate the…
Posted May 21, 2026
Elucidating the molecular mechanisms of secondary cone degeneration in models of Retinitis Pigmentosa
US · IL NIH · grant
Project Summary Retinitis Pigmentosa (RP) is an inherited retinal disease afflicting 1 in 4,000 people worldwide. The disease progresses initially by rod photoreceptor degeneration caused by mutations in rod-specific genes, although differe…
Posted May 21, 2026
Elucidating the molecular and cellular mechanisms underlying cone survival in the peripheral retina in mouse models of Retinitis Pigmentosa
US · IL NIH · grant
Project Summary Retinitis Pigmentosa (RP) is an inherited retinal disease afflicting 1 in 4,000 people worldwide. The disease progresses initially by rod photoreceptor degeneration caused by mutations in rod-specific genes, although differe…
Posted May 21, 2026
Developmental regulation of oscillatory expression
US · IL NIH · grant
Biological oscillators, the rhythmic and regular increases and decreases of gene expression or protein activity, drive many dynamic molecular and morphological processes. Probably the most familiar is the circadian clock, but there are also…
Posted May 21, 2026
Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosis
US · IL NIH RePORTER · NAICS 541714 · grant
Project Summary This proposal details a 5-year career development training program focused on developing a patient-specific induced pluripotent stem cell (iPSC) model system to study the role of alveolar epithelial type 2 (AT2) cell dysfunc…
Posted May 21, 2026
Patient-specific iPSCs to model and treat the inception of pulmonary fibrosis
US · IL NIH · grant
Project Summary Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibrosis leading to disruption of the gas exchange unit and death within an average of four years from the time of diagnosis. A poor understanding of IPF pa…
Posted May 21, 2026
Hierarchies of spatiotemporal anticipation in the human brain
US · IL NIH · grant
PROJECT SUMMARY Everyday experience requires humans to make plans in a hierarchical fashion, so they can anticipate visual events that might occur seconds, minutes, hours, or longer in the future. For example, when walking through a city, i…
Posted May 21, 2026
Exploring prevention-related health beliefs of emerging adults with a family history of type 2 diabetes
US · IL NIH RePORTER · grant
Type 2 diabetes (T2D) has reached epidemic levels in the United States and, alarmingly, cases of early-onset T2D are steadily rising, with nearly 305,000 new cases diagnosed among 18 to 44 year-olds in the United States each year.1,2 Early-…
Posted May 21, 2026
Rapid sugar sensing from gut to brain
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT The average American adult consumes over 40 pounds of sugar per year. While sugar intake is necessary for energy metabolism and survival, this overconsumption has led to rampant obesity and diabetes. Therefore, it i…
Posted May 21, 2026
Steroid hormone dependent gene expression and neuroplasticity in the brain
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Steroid hormones in humans and other animals coordinate physiological and behavioral processes underlying optimal responses to the social environment. The brain is a major site of steroid hormone action; however, our knowled…
Posted May 21, 2026
Non-Invasive Venous waveform Analysis (NIVA) for Monitoring Volume Status in Heart Failure Patients
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY The primary focus of this research proposal is the refinement and advanced optimization of the Non-Invasive Venous waveform Analysis for Heart Failure (NIVAHF) device, building upon the foundational achievements made under R…
Posted May 21, 2026
Centrifugal regulation of olfactory function by melanin-concentrating hormone
US · IL NIH · grant
Project Summary The sense of smell is essential for maintaining full human health and quality of life. It plays an important role in the detection of environmental dangers as well guiding decisions such as what foods to eat. However, olfact…
Posted May 21, 2026
Modulating Fibrinolysis Dynamics by Leveraging Multivalent Avidity to Control Enzyme Activity
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Blood clots kill more humans than any other single pathogenic cause. A new or recurrent diagnosis of venous thromboembolism (VTE), which encompasses both pulmonary embolism (PE) and deep vein thrombosis (DVT), affects >900,0…
Posted May 21, 2026
Development of in Vivo Base Editing as a Genetic Treatment for Spinal Muscular Atrophy
US National Institute of Neurological Disorders and Stroke · grant
Abstract Spinal muscular atrophy (SMA) is a devastating neuromuscular disease and a leading genetic cause of infantile death worldwide. Despite exciting progress in the neuromuscular field that has resulted in novel therapies, there remains…
Posted May 21, 2026
SORL1 and its involvement in Alzheimer's disease pathogenesis and pathophysiology - Project 4
US National Institute on Aging · grant
PROJECT 4 SUMMARY Recent genetic studies have established that rare loss-of-function mutations in the Sortilin-related Receptor 1 (SORL1) gene confer extremely high risk for developing Alzheimer’s disease (AD). Currently, over 500 known co…
Posted May 21, 2026