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Showing 25 / 21760 · page 51/871
NICEATM Support Contract: Base Contract
US National Institute of Environmental Health Sciences · grant
"This is a Research and Development (R&D) contract to provide scientific and administrative support for the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM rese…
Posted May 21, 2026
NICEATM Support Contract: Meeting Support and Contract Travel
US National Institute of Environmental Health Sciences · grant
"This is a Research and Development (R&D) contract to provide scientific and administrative support for the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM rese…
Posted May 21, 2026
PQBP1 as a central regulator of inflammation in neurodegenerative diseases
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY: Neurodegenerative diseases pose significant challenges to public health and our understanding of brain function. Central to these conditions is the pathological accumulation of protein aggregates, notably alpha-synuclein, b…
Posted May 21, 2026
Enhancing anti-tumor immunity in head and neck neoplasms
US National Cancer Institute · grant
Project 1: Optimize anti-tumor immunity with neoadjuvant immunotherapy for oral cavity cancers Background: Oral squamous cell carcinoma (OSCC), typically caused by carcinogen exposure, carries a poor prognosis. Roughly half of all patients …
Posted May 21, 2026
Regulation of IgE production during aeroallergen sensitization
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract Asthma is a debilitating lung disease marked by reversible airway obstruction that affects over 5% of the US population and is growing in prevalence. In the majority of cases of asthma, allergic inflammation around …
Posted May 21, 2026
Mechanisms of GABAergic Signaling in the Suprachiasmatic Nucleus Network
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Hypothalamic suprachiasmatic nucleus (SCN) neurons express a cell-autonomous molecular clock that generates circadian rhythms and regulates physiological rhythms throughout the body. The molecular clock produces a c…
Posted May 21, 2026
PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAM
US National Cancer Institute · grant
This proposal represents the renewal application of the Pediatric Oncology Clinical Research Training Program (POCRTP), developed by Texas Children’s Cancer Center (TCCC), which is jointly supported by Baylor College of Medicine’s (BCM) Dep…
Posted May 21, 2026
PaRtnEring to build understanding oF gEnomics Responsibly: the PREFER Community Health Worker Genomics Research Education Program
US National Human Genome Research Institute · grant
Recent trends highlight the importance of championing a genomics research workforce that is well-prepared to support genomics research. Offering training to the entry-level workforce such as Community Health Workers (CHWs) can support genom…
Posted May 21, 2026
Facilitating the Implementation of Population-wide Genomic Screening (FOCUS)
US National Human Genome Research Institute · grant
Population-wide genomic screening (PGS) for Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, and Familial Hypercholesterolemia offers great promise in identifying the 1-2% of the population that unknowingly carries a pathogeni…
Posted May 21, 2026
Using a Superoxide Dismutase Mimetic to Mitigate Age-Associated, Radiation-Induced Cardiopulmonary Damage: Investigating the Role of Nitro-Oxidative Signaling and Mitochondrial Metabolism
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT. An aging population faces unique health challenges, including increased susceptibility to ionizing radiation (IR) toxicities due to oxidative and nitrative metabolic changes. Elderly individuals are particularly v…
Posted May 21, 2026
Linking in vivo hemodynamics with outcomes in Type B aortic dissection using 4D flow MRI
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Type B aortic dissection (TBAD) risk-stratification is increasingly relevant in the era of thoracic endovascular aortic repair (TEVAR), as outcomes and costs can differ significantly depending on treatment choice an…
Posted May 21, 2026
Anatomic Imaging Derived 4D Hemodynamics using Deep Learning
US National Heart Lung and Blood Institute · grant
SUMMARY - ABSTRACT Thoracic aortic aneurysm is a highly prevalent disease which can lead to devastating complications including dissection or rupture. Early detection and regular monitoring of these patients via regular surveillance imaging…
Posted May 21, 2026
CE25-021 - Estimating the impact of alternative crisis response models on community violence
US · IL NIH RePORTER · grant
PROJECT SUMMARY/ABSTRACT Community violence (CV) is a pressing public health crisis in the United States (US), disproportionately affecting youth and young adults (YYA) ages 10-34. Racial and ethnic minority YYA experience a hugely dispropo…
Posted May 21, 2026
CE24-013 - Community-based evaluation of a novel, system-wide harm reduction strategic plan for people experiencing homelessness in New York City
US National Center for Injury Prevention and Control · grant
PROJECT SUMMARY/ABSTRACT Overdose (OD) and homelessness are two interlinked national crises in the United States (US). More than 1.25 million people experience homelessness each year, and drug OD is the leading cause of death among people e…
Posted May 21, 2026
A comparative evaluation of overdose prevention programs in New York City and Rhode Island
US National Institute on Drug Abuse · grant
More than one million people have died from accidental drug overdose in the United States (US) in the past 20 years. In response to this unabating crisis, New York City opened the first two publicly recognized overdose prevention centers (O…
Posted May 21, 2026
Investigating GLI transcription factors as regulators of the pancreatic cancer microenvironment
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Pancreatic cancer is a deadly human malignancy, with a five-year survival rate of 11%. Further, the incidence of pancreatic cancer is rising and is projected to be the second-leading cause of cancer-related death in…
Posted May 21, 2026
Design, prediction, and prioritization of systematic perturbations of the human genome
US National Human Genome Research Institute · grant
ABSTRACT Noncoding genetic variation that alters gene regulation is of paramount importance for health, disease, and evolution. Diseases ranging in incidence from the most common to the most rare all have substantial risk associated with re…
Posted May 21, 2026
NAFLD Diagnosis and Outcomes
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Nonalcoholic fatty liver disease (NAFLD) affects 25-30% of US adults and has a major impact on healthcare burden and population health due to higher morbidity and mortality than the general population. Even though NAFLD can …
Posted May 21, 2026
Evaluating the Role of Social Connectedness in Recovery from Opioid Use Disorder during the Postpartum: A Supplement to Support Research Continuity
US National Institute on Drug Abuse · grant
ABSTRACT The current proposal requests an administrative supplement via NOT-OD-23-032 to support research continuity on NIH/NIDA R21DA058364 during a period of parental leave for the study MPI (Linde-Krieger). The goal of the parent study i…
Posted May 21, 2026
Research Training in Gastrointestinal and Hepatic Diseases
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY The accelerating pace of discovery in the basic biomedical, clinical and translational sciences now provides unprecedented opportunities to transform patient care in gastrointestinal and liver diseases. Over the past 35 year…
Posted May 21, 2026
Personalizing Therapies for Acute Kidney Injury in Cirrhosis
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT Acute kidney injury is a devastating complication of cirrhosis (Cirr-AKI). Current Cirr-AKI guidelines recommend all patients receive 1 g/kg/day of IV albumin for two days regardless of presenting features. However,…
Posted May 21, 2026
A 4D-tunable hydrogel for the study of the impact of the tumor microenvironment on the development of colorectal cancer
US National Cancer Institute · grant
Project Summary/Abstract The goal of this proposal is to develop a platform created from advanced biomaterials that enable novel investigations into the physiochemical roles of the tumor microenvironment (TME) on the origins of colorectal c…
Posted May 21, 2026
Development of an immunocompetent colon chip to model Crohn's Disease
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT The goal of this proposal is to develop an ex vivo experimental platform to enable novel investigations into the roles of the intestinal lumenal and basal microenvironment on the origins of Crohn's Disease (CD). CD …
Posted May 21, 2026
Design of an integrated microdevice to measure malignant lipid signaling in single cells from clinical samples
US National Cancer Institute · grant
PROJECT SUMMARY / ABSTRACT Engineering advances applied to miniaturized analytical instrumentation will be employed to improve sensitivity and throughput of thin-layer chromatography enabling single-cell analyses of the biochemical activity…
Posted May 21, 2026
Human Translational Bioinformatics Core
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY The overall objective of this SCORE is to elucidate sex differences in cardiometabolic disease and its risk factors and treatments using genetically modified mouse models, inbred mouse strains, and in vitro or cell-based ex…
Posted May 21, 2026