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Showing 25 / 21760 · page 53/871
Metabolic Syndrome Outcomes Among Patients with Tuberculosis in Tanzania
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY The prevalence of noncommunicable diseases such as diabetes and metabolic syndrome is increasing in settings where infectious diseases like tuberculosis (TB) are common. There is a clear bidirectional interaction between di…
Posted May 21, 2026
Promoting Lead Academic Participating Sites (LAPS) Studies Accrual and Lung cancer Screening in Oklahoma
US National Cancer Institute · grant
Abstract/Summary Lung cancer mortality in Oklahoma is higher than the national average with age adjusted rate of 46.5 compared to 35 per 100,000 population. I am a thoracic medical oncologist with high interest in clinical and translational…
Posted May 21, 2026
Clinical Protocol and Data Management
US National Cancer Institute · grant
CLINICAL PROTOCOL AND DATA MANAGEMENT: ABSTRACT The Clinical Protocol and Data Management (CPDM) function provides comprehensive management and support services for clinical research activities at the Stephenson Cancer Center (SCC). CPDM se…
Posted May 21, 2026
CRCNS: Emergence of Coordinated Multi-Region Brain Activity Supporting Behavior
US National Institute of Neurological Disorders and Stroke · grant
Changes in interactions between neurons enable diverse computations and flexible behaviors. Such changes can occur very rapidly by rerouting information flow through existing connections, or more slowly by updating connections. The propos…
Posted May 21, 2026
Neuroimaging and Connectome Analysis as a Diagnostic and Prognostic Biomarker of SCI Induced Neuropathic Pain
US National Institute of Neurological Disorders and Stroke · grant
The identification of prognostic and diagnostic biomarkers of spinal cord injury (SCI) and SCI induced pain will help to assign SCI patients to the correct treatment and rehabilitation regimes. Chronic neuropathic pain (NP) is a complicated…
Posted May 21, 2026
Circulating Genomic Determinants of Treatment Failure in Hodgkin Lymphoma
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT PIs: Ash Alizadeh, M.D./Ph.D. & Maximilian Diehn, M.D./Ph.D. Classical Hodgkin lymphoma (HL) is among the most curable human malignancies. However, strategies to personalize HL therapies and to minimize long-term at…
Posted May 21, 2026
A Contrast-free Ultrasound-based Quantitative Angio Flow Imaging Technique to Assess Peripheral Arterial Disease of Lower Limb
US National Heart Lung and Blood Institute · grant
Abstract/Summary PAD is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Up to now, assessment of PAD is mainly performed by determination of stenosis or occlusion in the large ar…
Posted May 21, 2026
Vanderbilt-Nigeria Research Ethics Training Program (V-NET)
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
Project Summary Abstract To address the increasing demand for research in precision medicine in Africa, the proposed Vanderbilt- Nigeria Research Ethics Training Program (V-NET) is an innovative research ethics training program that involve…
Posted May 21, 2026
The Role of Tension Anisotropy in Fibroblast Activation
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary Fibroblasts play a crucial role in tissue function by generating and modulating contractile forces in response to environmental cues. Upon activation, they upregulate actin and myosin to enhance contractile force generation,…
Posted May 21, 2026
7T MRI as a potential tool for detection of pathology in Alzheimer's disease
US National Institute on Aging · grant
Project Summary/Abstract Amyloid-beta (Aβ) is a small piece of a larger protein called amyloid precursor protein. It accumulates in stages into microscopic amyloid plaques that are considered a hallmark of a brain affected by Alzheimer’s d…
Posted May 21, 2026
Proteomic and metabolomic trajectories of ARDS molecular phenotypes
US National Heart Lung and Blood Institute · grant
ABSTRACT. This application is for a K23 award for Narges Alipanah-Lechner, MD, MAS, a Clinical Instructor in the Division of Pulmonary/Critical Care Medicine at the University of California San Francisco. Dr. Alipanah- Lechner is a young in…
Posted May 21, 2026
Powassan virus evolution, fitness, and pathogenesis in the Northeast and Midwest United States
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Tick-borne Powassan virus (POWV) is an emerging public health threat, but has been understudied to date. Since its discovery in 1958, human cases of POWV have been reported in the United States, Canada, and Russia. Starting …
Posted May 21, 2026
Shared Resource 09: Hematological Tissue Bank Shared Resource (HTBSR)
US National Cancer Institute · grant
PROJECT SUMMARY – HEMATOLOGY TISSUE BANK SHARED RESOURCE (HTBSR) The Ohio State University Comprehensive Cancer Center (OSUCCC) Hematology Tissue Bank Shared Resource (HTBSR) is a longstanding biobank, established in 1997, that procures, pr…
Posted May 21, 2026
Targeting c-Myc stability in c-Myc overexpressing large B-cell lymphoma
US National Cancer Institute · grant
Project Summary Double (DH) and triple-hit (TH) lymphomas (L) are rare high grade B-cell lymphomas with diffuse large B-cell (DLBCL) morphology characterized by the co-occurrence of chromosomal translocations involving MYC, BCL2, and/or BCL…
Posted May 21, 2026
Shared Resource 09: Leukemia Tissue Bank (LTBSR)
US National Cancer Institute · grant
PROJECT SUMMARY – LEUKEMIA TISSUE BANK SHARED RESOURCE (LTBSR) The LTBSR is a longstanding biobank, established in 1997, that procures, processes, and stores biologic material from consenting patients with hematologic diseases. The LTBSR pr…
Posted May 21, 2026
Regulation of epithelial barrier
US National Institute of Dental and Craniofacial Research · grant
Project summary Periodontitis and peri-implantitis are oral diseases characterized by loss of oral homeostasis and induction of inflammation. Although downstream inflammatory events that occur in connective tissue have been well recognized,…
Posted May 21, 2026
Data-Analysis-Core
US National Institute on Aging · grant
Project Summary The Data Analysis Core (DAC) of the Minnesota Tissue Mapping Center (MN TMC) of Senescent Cells (SnCs) is co-directed by Constantin Aliferis, an expert in biomedical data science and bioinformatics modeling with a long track…
Posted May 21, 2026
Real-Time, Non-Invasive Thrombus Characterization using Ultrasound Responsive Nanodroplets
US National Heart Lung and Blood Institute · grant
ABSTRACT Thrombosis is a leading cause of morbidity and mortality worldwide, associated with several serious health complications including pulmonary hypertension, cardiovascular disease, and death. As thrombi mature, their structural and m…
Posted May 21, 2026
Atherosclerosis in cocaine addiction: imaging risk with PET/MR
US National Institute on Drug Abuse · grant
Cocaine use disorder (CUD) can cause vascular disease mainly through chronic vasoconstriction effects. Atherosclerosis can be present in the carotid artery (CA) even without overt clinical symptoms. Once symptoms are observable, the artery …
Posted May 21, 2026
STRONG HEART STUDY (SHS)- FIELD CENTER (FC)- TASK ORDER 001
US National Heart Lung and Blood Institute · grant
The Strong Heart Study (SHS) is a longitudinal observational study of two combined cohorts followed prospectively: the original SHS cohort recruited in 1989 to 1991 and a Strong Heart Family Study (SHFS) cohort recruited in 1998 to 1999. T…
Posted May 21, 2026
Developing Selective P-catalysts for Dehydrative Transformations
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY/ABSTRACT This proposal will elucidate the various steric and electronic parameters of a P-catalyst necessary for enantioinduction in tandem amidation/amide functionalizations through deoxygenative P(III)/P(V) catalysis; an …
Posted May 21, 2026
Role of IGFBP3 in Neonatal Heart Regeneration
US National Heart Lung and Blood Institute · grant
Project Summary/Abstract This is an application for a K08 award for Dr. Shah Ali, MD, an Instructor in Cardiology at the University of Texas Southwestern (UTSW), for his transition from Instructor to independent investigator in basic cardi…
Posted May 21, 2026
Accurate High-Resolution Tissue Characterization for Breast Cancer Screening Using Transmission and Reflection Ultrasound Tomography
US National Institute of Biomedical Imaging and Bioengineering · grant
PROJECT SUMMARY/ABSTRACT Breast cancer is the most widely diagnosed cancer in women in the United States and the most commonly occurring cancer worldwide according to the World Health Organization. The primary screening method for non- pal…
Posted May 21, 2026
Administrative and Field Coordination Core
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY / ABSTRACT (Administrative and Field Coordination Core) To maximize the cohesiveness and impacts of the Precision Cardiovascular Disease Phenotyping and Pathophysiological Pathways in the CARRS cohort (Precision-CARRS), the …
Posted May 21, 2026
Design and Evaluation Core
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Core B AIMS: Design and Evaluation Aim 1. To facilitate practice, program, and policy research by leveraging existing local, regional, and national databases to improve decision-making for diabetes prevention and management. Rationale: S…
Posted May 21, 2026