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21,760 contracts

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Showing 25 / 21760 · page 8/871
Aryl hydrocarbon receptor and bilirubin as therapeutic target for ICH
US · IL NIH · grant
After intracerebral hemorrhage (ICH), phago(endo)cytosis of hematoma components [erythrocytes (RBC), hemoglobin (Hb) and heme], by microglia/macrophages (MMΦ) is essential for removal/detoxification of the hematoma, resolution of inflammati…
Posted May 21, 2026
Improving access to opioid use disorder treatment among marginalized patients with a tailored telehealth intervention
US National Institute on Drug Abuse · grant
PROJECT SUMMARY/ABSTRACT: The goal of this K23 award is to give the PI the skills and preliminary data needed to improve access to opioid use disorder (OUD) treatment with buprenorphine via telehealth care. Dr. Aronowitz is proposing a res…
Posted May 21, 2026
The contributions of interaurally correlated signals and interaurally symmetric place of stimulation for the binaural auditory system
US National Institute on Deafness and Other Communication Disorders · grant
PROJECT SUMMARY / ABSTRACT Binaural hearing provides substantial benefits in complex listening environments, improving the ability to understand speech and providing the ability to localize sounds. However, in order to take advantage of bin…
Posted May 21, 2026
Microbiota Metallophores: Probing Interactions and Nutrient Dynamics of the Human Gut
US · IL NIH · grant
Project Summary/Abstract A healthy human microbiome is intrinsically linked to vital physiological aspects such as development, immune function, and nutrition. The composition and function of the human microbiota is significantly influenced…
Posted May 21, 2026
Leukotriene B4 Regulation in Heart
US National Heart Lung and Blood Institute · grant
PROJECT ABSTRACT Patients with type 2 diabetes (T2DM) are at increased risk (~50%) relative to non-diabetic individuals of suffering sudden cardiac death (SCD), most often due to fatal ventricular arrhythmias such as torsades de pointes (T…
Posted May 21, 2026
Channelopathies of Inflammation
US · IL NIH · NAICS 541714 · grant
PROJECT ABSTRACT Obesity is associated with a higher risk for the development of malignant ventricular tachyarrhythmias (VT), particularly under conditions of repolarization disorders and QT interval prolonging mechanisms (an established ri…
Posted May 21, 2026
Pharmacokinetics of Long-Acting Preparations of Antitubercular Drugs in Rodents
US · IL NIAID Division of AIDS · grant
Preclinical Services for HIV Therapeutics: The purpose of these Indefinite Delivery/Indefinite Quantity contracts is to provide the extramural scientific community with research materials and preclinical product development support for cand…
Posted May 21, 2026
B. thuringiensis crystal proteins as powerful next-generation anthelmintics
US · IL NIH · grant
New treatments are urgently needed for parasitic gastrointestinal nematodes (GINs; hookworms, whipworms, roundworms) that infect ~1.5 billion people and cause significant morbidity in children, pregnant women, and working adults. Mass drug …
Posted May 21, 2026
Combining B. thuringiensis crystal proteins with small molecule anthelmintics to combat parasitic nematode resistance
US · IL NIH · grant
New treatments are urgently needed for parasitic gastrointestinal nematodes (GINs; hookworms, whipworms, roundworms) that infect ~1.5 billion people and cause significant morbidity in children, pregnant women, and working adults. The main d…
Posted May 21, 2026
Prefrontal impairment with stress- NE receptor subtype mechanisms.
US National Institute of Mental Health · grant
Abstract- The dorsolateral prefrontal cortex (dlPFC) mediates working memory and top-down control, but is impaired by acute or chronic stress, and is dysfunctional in most mental disorders. Stress exposure increases norepinephrine (NE) rele…
Posted May 21, 2026
Student Research Laboratory Core
US National Institute of General Medical Sciences · grant
Abstract: Student Research Laboratory Core Central to the development of any research center is the availability of research service cores to center investigators. Such cores can broaden investigators’ scope of research by supplying expert…
Posted May 21, 2026
Deciphering the role of heterochromatin in telomere function and maintenance mechanisms
US · IL NIH · grant
PROJECT SUMMARY Telomeres are nucleoprotein structures that protect the ends of linear chromosomes and thereby maintain genome stability. Telomeres solve both the end-protection and the end-replication problems: 1) They inhibit DNA damage a…
Posted May 21, 2026
Deciphering the function of the APE2 nuclease during repair by alternative end-joining and its role in HR-deficient cells
US · IL NIH · grant
PROJECT SUMMARY Homologous recombination (HR), a pathway that repairs DNA double strand breaks (DSB), is frequently mutated in cancers. HR-deficient cancers are prone to genomic instability and are critically dependent on other DNA repair …
Posted May 21, 2026
Improving HIV Prevention Through a Psychological Flexibility-Based Approach
US National Institute of Mental Health · grant
There continues to be a high incidence of HIV, particularly in the South. Thus, interventions to enhance engagement in prevention services are urgently needed. Engagement in pre-exposure prophylaxis (PrEP) care among people at risk of HIV l…
Posted May 21, 2026
Defective heme transport in the development of congenital hydrocephalus
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Congenital hydrocephalus (CH) is a debilitating neurologic condition with complex genetic and environmental inputs, characterized by excessive accumulation of cerebro-spinal fluid (CSF) and enlarged ventricles. Emer…
Posted May 21, 2026
Structure-guiding tools to study the role of choline in the development of congenital hydrocephalus
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY The blood-brain barrier (BBB) is a term used to describe the unique properties of the blood vessels that vascularize the central nervous system (CNS) and restrict the movement of nutrients, ions and cells between the blood a…
Posted May 21, 2026
The role of heme in retinal vascular development and disease
US · IL NIH · NAICS 541714 · grant
PROJECT ABSTRACT Retinal vascular diseases are major causes of vision loss in the United States and around the world. To better treat these disorders, we need to understand the signaling pathways that control the growth and integrity of ret…
Posted May 21, 2026
The Interdisciplinary Training, Education and Research Activities for Assessing and Controlling Contaminants from Emerging Technologies (InTERACCT) Program
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY To ensure that emerging technologies grow without causing illness or injury to workers and the public, a professional workforce must be prepared with the ability to anticipate, recognize, evaluate, and control exposures to h…
Posted May 21, 2026
Biomarkers Core (Core E)
US National Institute on Aging · grant
SUMMARY: CORE E- BIOMARKER CORE. The Biomarker Core supports the Harvard Aging Brain Study (HABS) Program Project Grant (PPG) by processing and banking blood (plasma, serum, whole blood, buffy coat, RNA, miRNA, DNA and cell lines) and cereb…
Posted May 21, 2026
Pharmacokinetic and pharmacodynamic relationships for antibacterial treatment of shigellosis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract Enteric infection with Shigella spp. can lead to symptoms ranging from acute watery diarrhea to sudden, severe dysentery. Approximately 212,000 diarrheal deaths annually are attributed to Shigella (12.5% of total d…
Posted May 21, 2026
Modex, a cloud-based, centralized health economic model marketplace to reduce costs and enhance equity in cancer
US National Cancer Institute · grant
New cancer drugs have long been at the forefront of research and debate about rising healthcare expenditure in the United States; researchers and decision-makers rely on evidence to support fair pricing and ensure patient access. HE models …
Posted May 21, 2026
The role of alpha-synuclein in nucleolar DNA double-strand break repair and cellular senescence
US National Institute on Aging · grant
PROJECT SUMMARY Genomic stability is very closely linked to diseases associated with aging, like neurodegeneration and cancer. Interestingly, strong evidence suggests unexpected links between these two diseases, since epidemiological studie…
Posted May 21, 2026
FRESH Network: Assisting Mansfield Schools with Understanding Contanimants in School Meals and Transitioning to Better Food Systems
US Food and Drug Administration · grant
Project Abstract Mansfield School District (Arkansas) FRESH Network: Assisting Mansfield Schools with Understanding Contaminants in School Meals and Transitioning to Better Food Systems Across Arkansas and much of the country, school meals …
Posted May 21, 2026
Development of synthetic heparin to protect liver graft from ischemia reperfusion injury during transplantation
US · IL NIH · grant
Project Summary/Abstract This STTR phase II application is to seek continuation support to develop a carbohydrate-based reagent, dekaparin, to protect from liver damage during the organ recovery and preservation process. Liver transplant is…
Posted May 21, 2026
Identifying and characterizing new therapy targets in TDP-43 proteinopathies
US · IL NIH · NAICS 541714 · grant
Project Summary: Age-related neurodegenerative diseases are a rapidly growing cause of mortality and morbidity worldwide. The overwhelming majority of neurodegenerative disease, referred to as ‘sporadic,’ is caused by poorly understood inte…
Posted May 21, 2026