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The contributions of interaurally correlated signals and interaurally symmetric place of stimulation for the binaural auditory system
National Institute on Deafness and Other Communication Disorders
GRANT

PROJECT SUMMARY / ABSTRACT Binaural hearing provides substantial benefits in complex listening environments, improving the ability to understand speech and providing the ability to localize sounds. Ho

Microbiota Metallophores: Probing Interactions and Nutrient Dynamics of the Human Gut
National Institute of General Medical Sciences
GRANT

Project Summary/Abstract A healthy human microbiome is intrinsically linked to vital physiological aspects such as development, immune function, and nutrition. The composition and function of the huma

Defective heme transport in the development of congenital hydrocephalus
National Institute of Neurological Disorders and Stroke
GRANT

PROJECT SUMMARY/ABSTRACT Congenital hydrocephalus (CH) is a debilitating neurologic condition with complex genetic and environmental inputs, characterized by excessive accumulation of cerebro-spinal f

The role of alpha-synuclein in nucleolar DNA double-strand break repair and cellular senescence
National Institute on Aging
GRANT

PROJECT SUMMARY Genomic stability is very closely linked to diseases associated with aging, like neurodegeneration and cancer. Interestingly, strong evidence suggests unexpected links between these tw

Identifying and characterizing new therapy targets in TDP-43 proteinopathies
National Institute on Aging
GRANT

Project Summary: Age-related neurodegenerative diseases are a rapidly growing cause of mortality and morbidity worldwide. The overwhelming majority of neurodegenerative disease, referred to as ‘sporad

Applying digital phenotypes and epigenetics to understand clinical outcomes in acute hypoxemic respiratory failure without acute respiratory distress syndrome (NAHRF)
National Heart Lung and Blood Institute
GRANT

PROJECT SUMMARY Each year approximately 1 million adults receive invasive mechanical ventilation in the United States for acute hypoxemic respiratory failure (AHRF), and 30-40% of these patients die i

Serologic measures of enteric pathogen transmission for intervention studies and population monitoring in low-resource settings
National Institute of Allergy and Infectious Diseases
GRANT

Enteric pathogen infections cause an immense disease burden among children in low-resource settings. Understanding pathogen-specific transmission in high burden populations, and whether transmission i

Longitudinal EEG and Environmental Trajectories Leading to ADHD and Disruptive Behaviors from Infancy to Preschool
National Institute of Mental Health
GRANT

Project Summary Attention deficit hyperactivity disorder (ADHD) and disruptive behaviors (DBs) affect up to 9% of children. Under-diagnosis and under-treatment of ADHD and DBs disproportionately affec

Longitudinal EEG and Environmental Trajectories Leading to ADHD and Disruptive Behaviors from Infancy to Preschool
National Institute of Mental Health
GRANT

Project Summary Attention deficit hyperactivity disorder (ADHD) and disruptive behaviors (DBs) affect up to 9% of children. Under-diagnosis and under-treatment of ADHD and DBs disproportionately affec

Toward efficient performance for deep learning on medical imaging
National Heart Lung and Blood Institute
GRANT

Project Summary / Abstract Objective — The goal of this renewal is to continue developing and optimizing novel deep learning (DL) and related methods to improve diagnosis and clinical decision-making

Toward efficient performance for deep learning on medical imaging
National Heart Lung and Blood Institute
GRANT

Project Summary / Abstract Objective — The goal of this renewal is to continue developing and optimizing novel deep learning (DL) and related methods to improve diagnosis and clinical decision-making

Platelet alphaIIbbeta3 activation and its therapeutic targeting
National Heart Lung and Blood Institute
GRANT

Abstract Platelet integrin αIIbβ3 plays a central and nonredundant role in hemostasis and thrombosis. It is normally kept in a default inactive conformation in resting free-flowing platelets in the ci

C-type natriuretic peptide in hypertrophic cardiomyopathy
National Heart Lung and Blood Institute
GRANT

PROJECT SUMMARY/ABSTRACT The overall objective of this proposal is to further our understanding of the biology and therapeutic potential of C-type natriuretic peptide in hypertrophic cardiomyopathy (H

Ecological Assessment of Proximal Risk Factors for Suicide During Care Transitions
National Institute of Mental Health
GRANT

Project Summary/Abstract Suicidal ideation and behavior are growing public health problems in the United States. This is particularly concerning during the high-risk period following discharge from ps

Ecological Assessment of Proximal Risk Factors for Suicide During Care Transitions
National Institute of Mental Health
GRANT

Project Summary/Abstract Suicidal ideation and behavior are growing public health problems in the United States. This is particularly concerning during the high-risk period following discharge from ps

Molecular Targets for Cancer Detection and Treatment
National Cancer Institute
GRANT

This Molecular Targets Training Program has to meet workforce needs for scientifically trained medical oncology physicians who will translate increasingly technical knowledge in molecular biology to a

Horizontal gene transfer as the source of evolutionary innovation in eukaryotes
National Institute of General Medical Sciences
GRANT

PROJECT SUMMARY Horizontal gene transfer (HGT) represents a dominant force in bacterial evolution, however its role in shaping the evolutionary processes in eukaryotic genomes has been a subject of in

Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood
National Institute of Environmental Health Sciences
GRANT

PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) and hypertension (HTN) are substantial public health concerns in the US and are important risk factors for other adverse outcomes including acute

Visualization of native chromatin-associated complexes to elucidate chromatin regulatory mechanisms
National Institute of General Medical Sciences
GRANT

Project Summary Chromatin organizes into distinct functional domains and regulates a wide range of biological processes, including gene expression, genome integrity maintenance, and DNA accessibility.

Dietary regulation of type 2 immunity and inflammation in the gut
National Institute of Allergy and Infectious Diseases
GRANT

PROJECT SUMMARY Understanding the role of environmental factors including signals derived from the diet and microbiota is key to improving therapeutic and intervention strategies for gastrointestinal

Dietary regulation of type 2 immunity and inflammation in the gut
National Institute of Allergy and Infectious Diseases
GRANT

PROJECT SUMMARY Understanding the role of environmental factors including signals derived from the diet and microbiota is key to improving therapeutic and intervention strategies for gastrointestinal

The Role of Neutrophils in Ischemia/Reperfusion Injury following Acute Stroke
National Institute of Neurological Disorders and Stroke
GRANT

PROJECT SUMMARY/ABSTRACT Inflammation is the body's response to tissue damage, including brain tissue after stroke. Stroke is one of the leading causes of death and disability, affecting more that 79

Antimicrobial Resistance Training Program in the Texas Medical Center (AMR-TPT)
National Institute of Allergy and Infectious Diseases
GRANT

PROJECT SUMMARY/ABSTRACT The rise of antibiotic-resistant microorganisms globally has become a critical public health priority due to the devastating consequences that it may have to the world health

Impact of Metals on Biological Aging and Cardiometabolic Traits in Adolescents
National Institute of Environmental Health Sciences
GRANT

ABSTRACT The ubiquitous presence of toxic metal exposures in the environment is a global public health concern, with disadvantaged populations disproportionately exposed and susceptible to adverse eff

THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER
National Heart Lung and Blood Institute
GRANT

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor

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