Live opportunities

21,760 contracts

🏛Federal 🗽State 🏞County 🏙City 🎓Schools 🚇Districts 📚Universities
Showing 25 / 21760 · page 11/871
Extracellular Potassium and Astrocytic Kir4.1 Modulate Interneuron Activity in the Cerebral Cortex
US National Institute of Neurological Disorders and Stroke · grant
Astrocyte potassium buffering through the inwardly rectifying potassium channel, Kir4.1, is a crucial and essential function. Changes in Kir4.1 have been implicated in epilepsy, seizures, and several neurodegenerative disorders. However, un…
Posted May 21, 2026
Impact of polymicrobial interactions and within-host adaptation on CAUTI pathogenesis
US · IL NIH · grant
Project Summary/Abstract Urinary tract infection (UTI) is one of the most common infections worldwide and a leading cause of morbidity and healthcare expenditures across all ages. Older adults and individuals with catheters have a particula…
Posted May 21, 2026
The urothelial glycosaminoglycan layer: composition and contribution to pathogen fitness during catheter-associated urinary tract infection
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary/Abstract Urinary tract infection (UTI) is one of the most common infections worldwide and a leading cause of morbidity and healthcare expenditures across all ages. Older adults and individuals with catheters have a particula…
Posted May 21, 2026
Evolution of Pseudomonas aeruginosa in premise plumbing and impact on cystic fibrosis respiratory disease pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
Potable water is a major source of opportunistic pathogens that cause a variety of life-threatening infections in immunocompromised people, with a yearly US economic burden of $2.4 billion dollars. Biofilms ubiquitously coat surfaces within…
Posted May 21, 2026
Ultra-precision diagnostics for ALK+ non-small cell lung cancer
US · IL NIH RePORTER · NAICS 541714 · grant
Background & Significance: Identifying ALK-positive lesions, which are highly responsive to treatment with Crizotinib or Alectinib, is a high-priority for managing patients with ALK+ Non-Small Cell Lung Cancer (NSCLC). A blood-based compani…
Posted May 21, 2026
Cancer Research Training andEducation Coordination
US National Cancer Institute · grant
Training and education have a long-standing legacy at the Sidney Kimmel Comprehensive Cancer Center (SKCCC). The goal of this Cancer Research Training and Education Coordination (CRTEC) program is to coordinate and track the success of thes…
Posted May 21, 2026
Molecular Targets for Cancer Detection and Treatment
US · IL NIH · NAICS 611310 · grant
This Molecular Targets Training Program has to meet workforce needs for scientifically trained medical oncology physicians who will translate increasingly technical knowledge in molecular biology to advances for cancer patients. The Program…
Posted May 21, 2026
Cancer Genetics of Long Telomere Syndromes
US National Cancer Institute · grant
Abstract This application focuses on understanding the genetic basis of a recently recognized cancer-prone syndrome caused by long telomere length. It is driven by extended cellular longevity, a mechanism that is distinct from tumor suppres…
Posted May 21, 2026
Robotic System for Spinal Decompression and Interbody Fusion
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Summary The goal of this application is to develop a robotic workstation with integrated, novel imaging and visualization capabilities to perform complex tasks in minimally-invasive spine (MIS) surgery that cannot be currently performed wi…
Posted May 21, 2026
Epigenetic mechanisms of regulation of histone lysine methyltransferases involved in leukemia
US National Institute of General Medical Sciences · grant
Chromatin conformation underlies accessibility of enzymes that participate in transcription, replication, recombination, and repair. Many chromatin-regulatory mechanisms ensure that enzymes such as RNA polymerase II gain access to and effic…
Posted May 21, 2026
Molecular basis for aberrant de novo DNA methylation in cancer
US · IL NIH · grant
PROJECT SUMMARY Methylation of cytosine in the context of CpG dinucleotides is an essential and highly conserved chromatin modification. It plays a critical role in gene regulation, cell differentiation and organismal development. Aberrant …
Posted May 21, 2026
Molecular Mechanisms of Chromatin Remodeling and Deacetylation
US · IL NIH · grant
Project Summary Chromatin structure and function are dynamically regulated by ATP-dependent chromatin remodelers and Sirtuin histone deacetylases, two critical enzyme families that play pivotal roles in DNA transcription, replication, repai…
Posted May 21, 2026
Evaluating the Effect of a Local Microvascular Tissue Graft Treatment in Rat Models of Diabetic Peripheral Neuropathy
US · IL National Institutes of Health · NAICS 541714 · small business · grant
PROJECT SUMMARY Diabetic peripheral neuropathy (DPN) is a progressive disease, and currently, there are no well-recognized effective treatments shown to be able to address DPN and improve or return sensation to extremities. MicroVascular Ti…
Posted May 21, 2026
Modeling ASD-linked genetic mutations in 3D human brain organoids
US · IL NIH · grant
Project summary / Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose underlying mechanisms have been proposed to include abnormal excitatory-inhibitory balance in brain regions including the cerebral cortex. The …
Posted May 21, 2026
Neuron-Oligodendrocyte Communication Underlying Myelin Distribution in the Neocortex
US · IL National Institutes of Health · grant
Summary: Over vertebrate evolution, the development of the myelin sheath has contributed to the expansion of the central nervous system and the emergence of complex brain function. Cumulative evidence indicates that the level of myelination…
Posted May 21, 2026
Comprehensive single-cell atlas of the developing mouse brain
US · IL NIH · grant
PROJECT SUMMARY The developing mouse brain is a foundational experimental model for investigation of the origins of cell types in the mammalian brain. Comprehensive knowledge of mouse brain development is critical for comparative studies of…
Posted May 21, 2026
Circulating and Brain Lipidomics, Cognition and Dementia
US National Institute on Aging · grant
Decline in cognition and the onset of Alzheimer’s disease (AD) and dementia impose a devastating personal and interpersonal burden with huge societal costs. To provide insights into new mechanisms and identify novel targets to prevent AD, d…
Posted May 21, 2026
Mitochondrial Function and Multiomics in Aging-related Disease: Identifying Novel Biomarkers and Causal Relationships
US · IL NIH · NAICS 541714 · grant
Mitochondria play an essential role in cellular function and impact human health through varied mechanisms, including energy metabolism, cell signaling, and apoptosis. We have previously demonstrated that mitochondrial DNA copy number (mtDN…
Posted May 21, 2026
Functional Characterization of Mitochondrial Genome Nonsense Mutations
US National Institute on Aging · grant
Mitochondria play an essential role in cellular function and impact human health through varied mechanisms, including energy metabolism, cell signaling, and apoptosis. Many aging-related diseases have a mitochondrial (MT) component, with st…
Posted May 21, 2026
Human Mitochondrial Variation and Sudden Cardiac Arrest Risk and Resuscitation
US · IL NIH · grant
Sudden cardiac arrest (SCA) is a major public health concern, accounting for up to 400,000 deaths each year. While SCA cases are heterogeneous in etiology, the most common underlying pathologic substrate is ischemic heart disease and the mo…
Posted May 21, 2026
Systematic stabilization of specific protein-protein interactions
US · IL NIH · grant
Abstract Protein-protein interactions (PPIs) are ubiquitous in biology, and their dysregulation is closely associated with diseases, from cancer to neurodegeneration to rare genetic disorders. PPIs often form complex networks that include h…
Posted May 21, 2026
Horizontal gene transfer as the source of evolutionary innovation in eukaryotes
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Horizontal gene transfer (HGT) represents a dominant force in bacterial evolution, however its role in shaping the evolutionary processes in eukaryotic genomes has been a subject of intense debate. Class Bdelloidea of the ph…
Posted May 21, 2026
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons
US National Institute of Mental Health · grant
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons The versatile and powerful functional properties of the brain are reflected in the neuronal activity patterns and computations, and their evolution over time due…
Posted May 21, 2026
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
US · IL NIH · grant
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format One of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks via theory/modeling. As the planning do…
Posted May 21, 2026
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
US · IL NIH · grant
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment Patterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states, typically employing periodic light flicker…
Posted May 21, 2026