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Showing 25 / 21760 · page 14/871
Interrogation of Genetic Dependencies in Renal Cell Carcinomas.
US · IL NIH · grant
We have established a Cas9-Cas12a CHyMErA-based combinatorial CRISPR screening platform in patient-derived renal cell carcinoma (RCC) cell lines and confirmed robust nuclease expression and genome editing efficiency. Leveraging a genome-wid…
Posted May 21, 2026
Photostimulation of In Vitro Cardiac Tissue Models via Programmable Peptide Coassembly of Cell-Interfacing Donor-Acceptor Aggregates
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Natural biomacromolecular interactions utilize non-covalent interactions to generate stable, hierarchically ordered structures critical for their biological function. In this project, we develop a biomolecular-based technolo…
Posted May 21, 2026
Optically Promoting Cardiac Maturation Using Engineered Peptides
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY The promise of human stem cell-derived cardiomyocytes (hSC-CMs) opens doors towards the feasibility of personalized medicine against cardiac diseases and for performing more accurate drug discovery studies. Moreover, hSC-CM…
Posted May 21, 2026
Efficacy of an activities-based locomotor training program in children with cerebral palsy
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY Cerebral Palsy (CP) is a common lifelong neurological disorder affecting movement and posture, requiring ongoing physical therapy to achieve functional gains. This project aims to evaluate the efficacy of an Activities- Base…
Posted May 21, 2026
Developmental GTEx Laboratory, Data Analysis and Coordination Center
US National Human Genome Research Institute · grant
ABSTRACT Understanding the transcriptional programs governing cell identity and function is key to many outstanding questions in biology and biomedicine. Most variants associated with common diseases and traits lie in non- coding, regulator…
Posted May 21, 2026
Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT)
US National Institute on Drug Abuse · grant
ABSTRACT: (max 30 lines) There is an enormous need to create a foundational dataset that will comprehensively catalog somatic mutations across a diverse range of human tissues, to understand their type, frequency, the cells, and anatomical …
Posted May 21, 2026
Role of HMGB1 in an experimental model of Bacterial ligand induced Vasculitis
US · IL NIH · NAICS 541715 · grant
ABSTACT Kawasaki Disease (KD) is an acute febrile pediatric systemic vasculitis of unknown etiology and is the leading cause of acquired heart disease among children. Untreated children develop coronary artery aneurysms (CAAs) leading to ca…
Posted May 21, 2026
Role of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitis
US · IL National Institutes of Health · grant
PROJECT ABSTRACT Kawasaki disease (KD), an acute febrile illness and systemic vasculitis of unknown etiology, is the leading cause of acquired heart disease among children in the US. Coronary artery aneurysms (CAA) develop in as many as 25%…
Posted May 21, 2026
Astrocyte modulation of striatal neuronal activity and behavioral sensitivity to alcohol
US · IL National Institutes of Health · grant
PROJECT SUMMARY / ABSTRACT Human clinical work indicates that the stimulant and sedative responses to alcohol (ethanol; EtOH) represent risk factors for the development of alcohol use disorder (AUD). Human neuroimaging studies and preclinic…
Posted May 21, 2026
Developing a Comparative Single-Cell Spatial Transciptomic Atlas of Brain Aging in Non-Human and Humans
US · IL NIH · grant
Project Summary Aging leads to an increased risk of neurodegenerative diseases such as Alzheimer's and Parkinson's that present significant public health challenges worldwide. Despite extensive research, the molecular mechanisms driving bra…
Posted May 21, 2026
Role of hexokinase 3 in macrophage polarization and cardiac remodeling after myocardial infraction.
US National Heart Lung and Blood Institute · grant
Project Summary Myocardial infarction (MI) is a leading cause of death, and macrophages play a critical role in the remodeling of the heart after MI. Hexokinases (HKs) catalyze glucose phosphorylation, and one HK isoform (HK3) is mostly exp…
Posted May 21, 2026
Hexokinase 1 mitochondrial binding and its role in cardiac endothelial cell function and the development of HFpEF
US National Heart Lung and Blood Institute · grant
Heart failure (HF) with preserved ejection fraction (HFpEF) is a prevalent disorder; however, our treatment options are limited. Studies show that endothelial cell (EC) dysfunction precedes the development of HFpEF and is a key player in th…
Posted May 21, 2026
Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress
US · IL NIH · grant
ABSTRACT: Young adults with juvenile systemic lupus erythematosus (JSLE) and dermatomyositis (JDM) have greater risk of cardiovascular disease (CVD) than the general population. Increased CVD risk in JSLE/JDM starts in childhood. Suboptimal…
Posted May 21, 2026
Identification of genomic regulatory elements in pancreas cells
US National Cancer Institute · grant
Using 3D chromatin assays, we generated an extensive enhancer interaction dataset for the human pancreas, spanning more than 20 donors and five major cell types, including both the exocrine and endocrine compartments. We employed a network …
Posted May 21, 2026
A Foot in Each World: Bridging the Divide Between Clinical Research and the Mobile Apps That Support It
US NIH RePORTER (National Institute of Mental Health - NIMH) · grant
Modified Project Summary/Abstract Section Santiago Arconada Alvarez, MS is an emerging leader in translational research software at Emory University who serves as the Associate Director of the AppHatchery initiative within the Georgia Clini…
Posted May 21, 2026
Understanding the Neuroanatomical Abnormalities of Repetitive Head Impacts
US · IL National Institute of Neurological Disorders and Stroke (NINDS) · NAICS 541715 · grant
PROJECT SUMMARY Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease defined by the widespread accumulation of hyperphosphorylated tau (p-tau) in perivascular spaces and by regional brain atrophy. Athletes engaged in contac…
Posted May 21, 2026
A life course perspective on gut microbiome aging and health in a non-human primate model
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY The gut microbiome has repeatedly been linked to major diseases of aging, including frailty, osteoporosis, and diabetes. However, after more than a decade of searching, there is still no consensus on which microbial species…
Posted May 21, 2026
Developing insertable cardiac monitors to assess social and environmental effects on the autonomic stress response in a nonhuman primate model of aging
US National Institute on Aging · grant
Project Summary The long reach of early life remains one of the most enduring puzzles in human health. From famine to poverty and neglect, adverse early life experiences lead to higher mortality and elevated risk for obesity, diabetes, and…
Posted May 21, 2026
MSPP Application
US · IL National Institutes of Health (NIH) · grant
NOT APPLICABLE no Abstract
Posted May 21, 2026
Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells
US · IL NIEHS · grant
The elegant organization of nucleic acids, predominantly DNA, into chromatin serves essential structural and regulatory roles in eukaryotic cells. This beautiful architecture allows for an expansion of the underlying genetic information by …
Posted May 21, 2026
Penalized mixture cure models for identifying genomic features associated with outcome in acute myeloid leukemia
US National Library of Medicine · grant
Molecular features associated with time-to-event outcomes, such as overall or disease-free survival, may be prognostically relevant or potential therapeutic targets. Therefore, analyzing data from high-throughput genomic assays with clinica…
Posted May 21, 2026
Genetic Contributors to White Matter Microstructure in Aging and Alzheimer’s Disease
US National Institute on Aging · grant
PROJECT SUMMARY While reductions in medial temporal lobe (MTL) white matter tract microstructure have been suggested to have a central role in longitudinal cognitive decline in aging and Alzheimer’s disease (AD), it is unknown what genetic …
Posted May 21, 2026
Small Molecule Therapeutics for Sickle Cell Anemia
US · IL NIH · grant
Project Summary Sickle Cell Disease (SCD) is a common genetic condition that affects approximately 100,000 people of African heritage in the US, and more than 4 million worldwide. The disease is caused by a single amino acid substitution in…
Posted May 21, 2026
NICHD: SERVICE: CCTN LB PHASE 2B CLINICAL TRIAL: NON-SEVERABLE
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) serves as the lead federal agency advancing research in fertility optimization. Within NICHD, the Contraceptive Development Program (CDP) under the …
Posted May 21, 2026
CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - EAST VA
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
There is a demand for new methods of contraception that can provide effective protection against unintended pregnancy as well as reduce the risk of venous thromboembolism (VTE), particularly for obese women. The mission of the Contraceptive…
Posted May 21, 2026