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Showing 25 / 21760 · page 16/871
Modulation of striatal cholinergic interneuron activity to prevent dystonic cerebral palsy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY This proposal will determine whether increasing striatal cholinergic interneuron (ChI) activity in the developing mouse brain can prevent dystonia following neonatal brain injury . Dystonic cerebral palsy (CP) due to neonata…
Posted May 21, 2026
Interplay Between Macrophages, Lipid Oxidation and the Nrf2/HO-1 Axis in the Cardiometabolic Toxicity Induced by Ultrafine Particles
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY/ABSTRACT Cumulative epidemiological and experimental evidence have shown that exposure to air pollutants leads to increased cardiovascular morbidity and mortality. These associations have been mostly ascribed to the particul…
Posted May 21, 2026
Dissecting the Role of Arachidonic Acid Metabolic Pathways Involved in Resolution Versus Progression of PM-Induced Cardiometabolic Toxicity
US National Institute of Environmental Health Sciences · grant
ABSTRACT Epidemiological and experimental data have shown that chronic exposure to ambient particulate matter (PM) leads to exacerbation of atherosclerosis, and increased cardiovascular morbidity and mortality. We have shown that mouse expo…
Posted May 21, 2026
Project 3: Integration of mammographic AI, clinical, and genomics information to improve breast cancer subtype- specific risk-based screening and prevention
US · IL National Institutes of Health · NAICS 541715 · grant
PROJECT 3: Summary The ongoing WISDOM risk-based breast cancer screening and prevention trial, which started in 2016, is a ground-breaking comparative effectiveness study to establish whether personalized breast cancer screening based on in…
Posted May 21, 2026
Role of cardiac clock misalignment in promoting arrhythmias in swine and donor human hearts
US · IL NIH · NAICS 541714 · grant
PROJECT ABSTRACT Sudden cardiac arrest (SCA) due to malignant ventricular arrhythmias remains a major cause of mortality in the US. While the majority of SCA patients have significant coronary artery disease (CAD), nearly one in three patie…
Posted May 21, 2026
Role of epicardial adiposity as a local mediator of VT/VF dynamics in donor human hearts
US National Heart Lung and Blood Institute · grant
Project Summary: Ventricular tachyarrhythmias are responsible for 300,000 sudden cardiac deaths a year in the US. The mechanisms underlying these arrhythmias in the majority of cases are ventricular tachycardia (VT) and/or ventricular fibri…
Posted May 21, 2026
University of Minnesota Summer Research in Neuroscience
US NIH RePORTER · grant
PROJECT DESCRIPTION Disorders of the nervous system are becoming more prevalent in our society, especially considering the growing elderly population who are more vulnerable to neurodysregulation. To meet the challenge of developing new and…
Posted May 21, 2026
Branched chain amino acids in heart failure
US · IL NIH · grant
SUMMARY Heart failure (HF) is a leading cause of death worldwide, and the leading cause of hospital admissions in patients over 65 in the US. Novel therapies, addressing novel pathways, are direly needed. The role of metabolism in cardiac p…
Posted May 21, 2026
Understanding how SGLT2 inhibitors protect from heart failure
US National Heart Lung and Blood Institute · grant
SUMMARY Heart failure is a leading cause of death worldwide, and the leading cause of hospital admissions in patients over 65 in the US. The role of metabolism in cardiac pathology has long been of interest, but no therapies that target car…
Posted May 21, 2026
Comprehensive quantification of fuel use in cold-induced thermogenesis in vivo
US · IL NIH · grant
SUMMARY Cold-induced thermogenesis (CIT) allows endotherms, including mammals, to maintain body temperature at ~37oC despite sometimes much colder ambient temperature. Pharmaceutical activation of CIT is being investigated by many groups as…
Posted May 21, 2026
Acetate and Endothelial Pathobiology
US · IL NIH RePORTER · grant
Chronic vascular inflammation is a hallmark of atherosclerosis, pulmonary arterial hypertension (PAH) and related conditions. It is also one of the principal causes of endothelial- to-mesenchymal transition (EndMT). We have recently demonst…
Posted May 21, 2026
Keeping fat out of muscle - Role of Branched Amino AcidsAmino Acids in Insulin Resistance
US · IL NIH · grant
Abstract Type 2 Diabetes Mellitus (T2DM) and insulin resistance (IR) are major contributors to global cardiovascular morbidity and mortality. The parent R01 grant uncovered that branched-chain amino acid (BCAA) catabolism promotes glucose d…
Posted May 21, 2026
Selective mTORC1 inhibition to prevent and treat NAFLD and NASH
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
As many as 100 million people in the US have non-alcoholic fatty liver disease (NAFLD), which can lead to hepatic injury and fibrosis, characteristics of non-alcoholic steatohepatitis (NASH), and in turn can progress to cirrhosis and hepato…
Posted May 21, 2026
Impact of Anticholinergic Medication on Salivary Function; Exploring Potential Genetic Markers for Dry Mouth
US National Institute of Dental and Craniofacial Research · grant
The growing medication use in all ages led to the fact that 20% of the US adult population take five or more drugs (polypharmacy). Over 500 medications commonly prescribed in polypharmacy (e.g., antidepressants, urinary antispasmodics, and …
Posted May 21, 2026
Clinical Core
US · IL NIH · grant
ABSTRACT – Clinical Core This goals of this research project are to advance our understanding of the pathophysiologic mechanisms contributing to cognitive and affective impairments in NPSLE. The Clinical Core will provide the necessary infr…
Posted May 21, 2026
Regulation of translation initiation by the epitranscriptome
US · IL NIH RePORTER · $1-5M · grant
Project Summary/Abstract My research program investigates how the epitranscriptome regulates protein synthesis and how this interplay affects cell fate decisions under normal homeostasis and stress conditions. The epitranscriptome is the co…
Posted May 21, 2026
Understanding A Molecular Cascade That Drives Neutrophil Mediated Pathology In Arthritis
US National Institute of Allergy and Infectious Diseases · grant
UNDERSTANDING A MOLECULAR CASCADE THAT DRIVES NEUTROPHIL MEDIATED PATHOLOGY IN ARTHRITIS Rheumatoid arthritis (RA) is a frequent chronic disease of the synovial joints characterized by painful loss of mobility due to unrestrained inflammat…
Posted May 21, 2026
Outreach, Recruitment, and Engagement (ORE) Core
US National Institute on Aging · grant
REVISED ABSTRACT: Outreach, Recruitment, and Engagement Core: Project Summary –2P30AG066530-06 (5769) The overall objective of the Outreach, Recruitment and Engagement Core (ORE Core) is to serve as the primary bilingual and bicultural …
Posted May 21, 2026
CRISPR-based transistors for high throughput multiplexed monitoring of CRISPR-based editing efficiency for Sickle cell disease
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT SCD is a heritable disease, which affects a patient's red blood cells (RBCs). This monogenic disorder is caused by a single nucleotide polymorphism (SNP) within the HBB gene. Despite progress in the treatment of SCD…
Posted May 21, 2026
PHARMACEUTICS FORMULATION/CHEMISTRY MANUFACTURING AND CONTROL CONSULTING SERVICES FOR SMALL MOLECULES AND/OR BIOLOGICS
US National Institute on Drug Abuse · grant
Pharmaceutics / Formulation / CMC Pharmaceutics / Formulation/ CMC consultants will be expected to provide executive (senior scientific)-level Pharmaceutics / Formulation/ CMC expertise and contribute feedback and guidance on projects to t…
Posted May 21, 2026
MEDICINAL CHEMISTRY CONSULTING SERVICES
US · IL NIH · grant
This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management; pain The medicinal chemistry Consultant will be expecte…
Posted May 21, 2026
Pain in the Elderly: Role of Hyperalgesic Priming
US · IL NIH · grant
Abstract Management of pain is a significant problem in the elderly, with the burden of chronic pain heavily tilted toward older adults. The high incidence of pain in the elderly has been suggested to be related to an increase in stress and…
Posted May 21, 2026
Naive CD8 T cell functional heterogeneity
US · IL NIH · grant
Project Summary There has been considerable progress in identifying subsets in effector, memory, and exhausted CD8 T cells, and our understanding of the role of each subset in response to infection has greatly improved. However, much less i…
Posted May 21, 2026
Cognitive challenge to reveal systemic neurophysiology biomarkers in pre-symptomatic Alzheimer’s disease
US · IL NIH · grant
The burden on Alzheimer’s disease (AD) is growing due to longer life span and lack of effective treatment. The knowledge gap exists for early detection and prediction of symptom onset. AD pathology (amyloid/tau) and synaptic dysfunction pre…
Posted May 21, 2026
The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brain
US National Institute on Aging · grant
PROJECT SUMMARY/ABSTRACT Although the pathophysiology of Alzheimer’s Disease (AD) is complex and multifactorial, vascular comorbidities and cerebrovascular insufficiency occur in almost two-thirds of AD patients. However, how cerebrovascula…
Posted May 21, 2026