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Showing 25 / 21760 · page 18/871
Regulation and Function of WIP1 Phosphatase and its Role in Tumor Cells
US · IL NIH · grant
The wild-type p53-induced phosphatase Wip1 (PP2Cdelta or PPM1D) is a member of the serine/threonine protein phosphatase 2C (PP2C) family. Although Wip1 is expressed at low levels in most normal cells, its transcription is induced by p53 aft…
Posted May 21, 2026
Small Molecular Inactivators of HIV
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
We have developed and studied our molecule both in the active form and as a prodrug. We have developed large-scale syntheses for these molecules and worked in collaboration to study their antiviral activity and evaluate their preclinical to…
Posted May 21, 2026
Chemically Modified Peptide Nucleic Acids
US · IL NIH · grant
Our research on Peptide Nucleic Acids (abbreviated as PNAs) focuses on introducing chemical modifications that will make this class of molecules broadly useful to detect sequences of nucleic acids and also to inspire new types of small mole…
Posted May 21, 2026
Stress, race, and cognitive mediators of SES-related disparities in behavioral obesity treatment outcomes
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Individuals of lower socioeconomic status (SES) lose only half as much weight in behavioral weight loss interventions as those of higher SES. This is a clinically meaningful difference in outcomes that has been cons…
Posted May 21, 2026
Hematologic Malignancies
US · IL National Cancer Institute (NCI) · grant
PROJECT SUMMARY Blood cancers afflict children and adults and are life-threatening. The Hematologic Malignancies (HM) Program is dedicated to understanding the causes of blood cancers and developing successful gene, drug, and cellular treat…
Posted May 21, 2026
Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center
US · MD NIH (National Institutes of Health) · grant
PROJECT SUMMARY This application is submitted in response to RFA-DK-22-502, “Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Clinical Centers (U01),” aka Phase 5 of CRIC, for the Hopkins/University …
Posted May 21, 2026
Mechanisms of Developmental Myelination
US · IL NIH · grant
PROJECT SUMMARY The long-term goal of this research program is to understand how specific axons of the developing central nervous system (CNS) are ensheathed with specific amounts of myelin, a specialized, proteolipid-rich membrane produced…
Posted May 21, 2026
A synaptogenic adhesion code for myelin specificity
US · IL NIH · grant
PROJECT SUMMARY Human brain function requires that neuronal axons are ensheathed by myelin, a specialized, lipid-rich membrane produced by oligodendrocytes, one of the principal glial cell types of the central nervous system. Myelin, the wh…
Posted May 21, 2026
Interrogating Mechanisms of Suppressed Tpex Immunotherapy Response in Metastatic Tumor-Draining Lymph Nodes
US · CA · San Francisco NIH · grant
PROJECT SUMMARY/ABSTRACT Tumor-reactive CD8 T cells become exhausted and lose their capacity to kill cancer cells in the tumor microenvironment. Progenitor-exhausted CD8 T cells (Tpex) found primarily in tumor-draining lymph nodes retain th…
Posted May 21, 2026
Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
US National Cancer Institute · grant
One third of B-cell lymphoma patients relapse and remain incurable despite effective targeted therapies. Although, the serially relapsing nature of these tumors support the presence of stem- like lymphoma repopulating cells, this notion rem…
Posted May 21, 2026
Identifying and Targeting 3D Regulatory Nodes that Maintain Glioblastoma Programs
US · IL NIH · grant
PROJECT SUMMARY Glioblastoma (GBM) is a highly aggressive and incurable brain tumor. The inter-patient and intra-tumoral heterogeneity of GBM, resulting from genetic alterations and epigenetic plasticity, poses a major challenge in its trea…
Posted May 21, 2026
Single-cell dissection of CD4 T cell changes in patients with immune-related adverse events following PD-1 inhibition
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary This application proposes a five-year research and training plan with a scientific focus on the mechanisms through which PD-1 checkpoint inhibition leads to immune-related adverse events (irAEs). The hypothesis is that de no…
Posted May 21, 2026
Midbrain Signals for Differential Reinforcement Learning
US National Institute of Mental Health · grant
Project Summary/Abstract Associative learning is a fundamental cornerstone of behavior and cognition, but the underlying neural mechanisms remain poorly understood. In vertebrates, the inferior colliculus (IC) is a layered, midbrain hub imp…
Posted May 21, 2026
Learning Related Plasticity in Mammalian Sound Localization Circuits
US · IL NIH · grant
Project Summary / Abstract Binaural cues enable sound localization, which supports active listening by spatially segregating competing sound streams. Consequently monaural hearing loss impairs sound localization and listening comprehension,…
Posted May 21, 2026
Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway
US · IL NIH · grant
Project Summary/Abstract Active listening is central to auditory cognition, supporting critical functions such as stream segregation, linguistic analysis and perceptual learning. To this end, the brain must accurately represent the physical…
Posted May 21, 2026
The Role of PICALM in Regulating Neurogenesis in Alzheimer's Disease
US · IL National Institutes of Health (NIH) · grant
Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Ninety five percent of AD cases are sporadic late onset (LOAD) of unknown cause. Aging is the greatest risk factor of LOAD. Pathologically, AD is characterized by brai…
Posted May 21, 2026
Hypothalamic neuronal circuits controlling survival behaviors
US National Institute on Drug Abuse · grant
Our interest is to understand how genetically identified cell types and their projections drive behaviors essential for survival. Using the mouse as our model system, we apply optogenetics and chemogenetics to manipulate neuronal circuits i…
Posted May 21, 2026
Regulation of the retinoblastoma (Rb) tumor suppressor by the ubiquitin-proteasome system
US · IL NIH · grant
PROJECT SUMMARY The retinoblastoma (Rb) protein is a prototypical tumor suppressor due to its role in restricting proliferation. In its active form, Rb functions as the key regulator of the G1/S cell cycle transition by physically binding t…
Posted May 21, 2026
Development of Strategies for the Enantioselective Synthesis of Heterocycles and Acyclic Amines
US National Institute of General Medical Sciences · grant
Project Summary/Abstract This objective of this proposal is to develop new synthetic methods for the enantioselective synthesis of bioactive molecules. Studies are centered on utilizing a new class of atropisomeric chiral biaryl ligand bein…
Posted May 21, 2026
Targeting the MET Pathway in Urothelial Carcinoma
US National Cancer Institute · grant
ICONIC-A phase 2 study of Ipilimumab, CabOzantinib, and NIvolumab in rare genitourinary (GU) cancers (ICONIC). This study includes 12 cohorts: bladder squamous cell carcinoma, bladder small cell carcinoma, bladder adenocarcinoma, bladder pl…
Posted May 21, 2026
Rare genitourinary tumors projects
US · IL NIH · grant
1. ICONIC-A phase 2 study of Ipilimumab, CabOzantinib, and NIvolumab in rare genitourinary (GU) cancers (ICONIC) The phase 1 study of combination CaboNivo and CaboNivoIpi included patients with rare GU histologies. Objective responses were …
Posted May 21, 2026
Bladder Cancer Program
US · IL NIH RePORTER · grant
I initiated a phase 3 clinical trial of adjuvant pembrolizumab post-cystectomy in patients with high-risk muscle-invasive urothelial carcinoma of the bladder and upper tract. I am the principal investigator on this Alliance/NCI-sponsored st…
Posted May 21, 2026
Using opioid industry documents to understand marketing of addictive medications
US National Institute on Drug Abuse · grant
ABSTRACT Prescription opioids have been a key driver of the US opioid crisis, resulting in nearly 500,000 overdose deaths from 1999 to 2019. The US has the highest rate of per capita opioid consumption in the world. Prior to class action la…
Posted May 21, 2026
Resource Development Core
US · IL NIH · grant
ABSTRACT: KIDNIT (Kidney Imaging: Developing Novel and Innovative Tools) is the Pittsburgh Center for Kidney Research’s Resource Development Core. Working in collaboration with kidney investigators and the Center’s Physiology and Model Syst…
Posted May 21, 2026
Role of AJC in umbrella cell function and dysfunction
US · IL NIH · grant
Abstract: A critical component of the umbrella cell barrier is the apical junctional complex (AJC), a multipartite, belt-like structure comprised of the tight junction, the adherens junction, desmosomes, and an associated cytoskeleton. Func…
Posted May 21, 2026