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Showing 25 / 21760 · page 50/871
CE24-012 - The Impact of Recreational Cannabis Legalization on Substance Use Outcomes
US National Center for Injury Prevention and Control · grant
PROJECT ABSTRACT This project will rigorously assess the impact of recreational cannabis legalization on opioid use and overdoses across the United States. With nearly half of the U.S. population living in states where recreational cannabis…
Posted May 21, 2026
Treatment of Knee Osteoarthritis via Intra-articular Delivery of an Immunosuppressive Enzyme
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary In osteoarthritis (OA), intra-articular inflammation is a key mediator of joint destruction and chronic joint pain. Unfortunately, current strategies to control joint inflammation have largely failed. To address this challe…
Posted May 21, 2026
Innervation of the knee and TMJ
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
The over-arching goal for the RE-JOIN Consortium is to define how the neurons that mediate chronic joint pain innervate different articular and peri-articular tissues, with a focus on the knee and temporomandibular joint (TMJ). With an impr…
Posted May 21, 2026
STepped Exercise Program for Knee Osteoarthritis: The STEP-KOA Study
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Knee osteoarthritis (OA) is a leading cause of pain and disability. Exercise is a first-line component of care for knee OA. However, the majority of individuals with knee OA are inactive, and exercise-based physical therapy (PT) is underuti…
Posted May 21, 2026
HSR&D Research Career Scientist Award
US Veterans Affairs · grant
This proposed Research Career Scientist award is to support the activities of Dr. Kelli Allen, an established Department of Veterans Affairs (VA) Health Services Research and Development (HSR&D) investigator, allowing her to her expand her …
Posted May 21, 2026
Precision Medicine Approach to Exercise-Based Interventions for Veterans with Knee Osteoarthritis
US Veterans Affairs · grant
Background: Knee osteoarthritis (OA) is a leading cause of pain and disability, and Veterans have markedly greater rates than non-Veterans. Exercise is a core component of care for knee OA, associated with modest average improvements in pai…
Posted May 21, 2026
Boosting Exercise Adherence in Knee Osteoarthritis (BOOST-OA)
US Veterans Affairs · grant
Background: Knee osteoarthritis (OA) is a leading cause of functional limitations among Veterans. Physical therapy (PT), with a focus on exercise, has strong evidence for improving physical function and other outcomes among individuals with…
Posted May 21, 2026
Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugates
US National Institute of General Medical Sciences · grant
Complex glycoconjugates play a pivotal role in bacterial survival, colonization, and virulence, and contribute to the interactions between symbiotic and pathogenic bacteria and their human hosts. Assembly of these macromolecules is initiate…
Posted May 21, 2026
Social Relationship Qualities as Predictors of Health & Aging from Adolescence through Mid-Adulthood
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary Public health efforts in adolescence aimed at life course physical health promotion have to date focused almost exclusively on addressing physiological risk factors and health behaviors (e.g., weight, smoking, etc.). This pr…
Posted May 21, 2026
Drug Screening Platform in the Light-Responsive Human Eye
US · IL NIH · small business · grant
Blinding diseases rob independence from millions of people in aging societies with poor metabolic and cardiovascular health. There are currently almost 1,000 planned or active clinical trials for investigational new drugs (INDs) to address …
Posted May 21, 2026
Contribution of CdiA to Pseudomonas aeruginosa pathobiology
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract Pseudomonas aeruginosa is a leading cause of healthcare-acquired infections worldwide. Many globally- distributed high-risk strains are emerging due to an increase in antibiotic resistance and acquisition of novel v…
Posted May 21, 2026
Discovery of GPR52 ligand probes for cocaine use disorder
US National Institute on Drug Abuse · grant
PROJECT SUMMARY Abuse of psychostimulants represents a major public health problem in the United States. Continued misuse of stimulants escalates in vulnerable individuals to a substance use disorder (SUD). SUDs are debilitating conditions …
Posted May 21, 2026
Altered Central Multisensory Processing in Post-concussion Vestibular Dysfunction
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Patients with persistent post-concussion vestibular dysfunction (PCVD) demonstrate visual motion sensitivity characterized by visual and motion stimuli inducing vestibular symptoms. We hypothesize that patients may…
Posted May 21, 2026
PRIME HRrEF: Novel Exercise for Older Patients with Heart Failure with Reduced Ejection Fraction
US National Institute on Aging · grant
Abstract. Heart failure (HF) is the leading cause of hospitalization among Americans ≥65 years old with 5.7 million sufferers and an annual of ~$39.2 billion. Patients with HF suffer from shortness of breath, fatigue and exercise intoleran…
Posted May 21, 2026
Explaining the potential role of physical activity in employment disparities after breast cancer
US National Institute on Minority Health and Health Disparities · grant
PROJECT SUMMARY Breast cancer is the most diagnosed cancer in the world with the largest survivorship group. The rise of breast cancer survivors (BCS) living longer, healthier lives merits attention to important areas of cancer survivorship…
Posted May 21, 2026
Role of epithelial ROS signaling in mediating psychological stress-induced mucosal dysfunction and colitis predisposition
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT: Inflammatory bowel diseases (IBD) are becoming more prevalent in the US and represent a major societal health concern. Exposure to psychosocial stressors increases the likelihood of developing IBD in genetically pr…
Posted May 21, 2026
Deploying Histotripsy Based Tumor Ablation Strategies to Treat Pancreatic Cancer
US National Cancer Institute · grant
PROJECT SUMMARY: Pancreatic cancer accounts for approximately 3% of all cancers in the United States and approximately 7% of all cancer related deaths. New treatment paradigms are direly needed. Emerging tumor ablation techniques have shown…
Posted May 21, 2026
Optimization of High Frequency Irreversible Electroporation (H-FIRE) for tumor ablation and immune system activation in pancreatic cancer applications
US National Cancer Institute · grant
PROJECT SUMMARY: Pancreatic cancer accounts for approximately 3% of all cancers in the United States and approximately 7% of all cancer related deaths. New treatment paradigms are direly needed. Emerging tumor ablation techniques have shown…
Posted May 21, 2026
Neuropeptide Y1 Receptor-Expressing Neurons in the Lateral Parabrachial Nucleus in Neuropathic Pain
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Pain is a complex phenomenon that elicits somatosensory and motor reflexive responses together with marked and long-lasting changes in emotional and autonomic states. While acute pain provides protection from tissue damage, …
Posted May 21, 2026
Developing novel CAR T cell designs using combinatorial antigen detection
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Candidate: The applicant, Greg Allen, MD/PhD, is a medical oncologist at UCSF with a long-term goal to lead an independent laboratory-based translational research program focused on cellular therapies. The K08 appli…
Posted May 21, 2026
Project 2 - The marine microbiome as a source for the synthesis, transformation, and distribution of seafood contaminants
US National Institute of Environmental Health Sciences · grant
Project 2 – Summary/Abstract Seafood is a major dietary source of diverse chemical pollutants, especially for populations who rely on seafood as their primary protein source. Despite industrial chemicals such as PBDE fire retardants, the i…
Posted May 21, 2026
Functional and structural characterization of human auditory cortex using high resolution MRI
US National Institute on Deafness and Other Communication Disorders · grant
PROJECT SUMMARY A more complete characterization of auditory cortical processing in humans is critical to understanding auditory perception and cognition. Without it, developing effective treatment options for various auditory processing de…
Posted May 21, 2026
Down Syndrome Clinical Cohort Coordinating Center (DS-4C) for the INCLUDE Project
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT The overarching goal of the proposed INCLUDE Clinical Cohort Coordinating Center (DS-4C), co-led by investigators at RTI International and Emory University, is to improve the health and well-being of individuals wit…
Posted May 21, 2026
Project 3- FXPOI: Mechanisms and Modifiers
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Abstract - Project 3 Up to an estimated 1 in 151 women carry a fragile X premutation (PM) allele, impacting over one million women in the US. In addition to being at risk for having a child with fragile X syndrome (FXS), the most common gen…
Posted May 21, 2026
NICEATM Support Contract: Optional Level of Effort
US National Institute of Environmental Health Sciences · grant
"This is a Research and Development (R&D) contract to provide scientific and administrative support for the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NICEATM rese…
Posted May 21, 2026