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21,760 contracts

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Showing 25 / 21760 · page 7/871
Conmigo: a multi-level mother-daughter physical activity intervention for pre-adolescent girls
US National Cancer Institute · grant
Fewer girls meet current physical activity (PA) guidelines, with lower rates observed among those from lower-income backgrounds and not socialized to engage in regular physical activity, contributing to widespread differences in health outc…
Posted May 21, 2026
Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations
US · IL NIH · grant
Project Summary/Abstract Loss of function progranulin (GRN) mutations, most of which cause haploinsufficiency, are a major genetic cause of frontotemporal dementia (FTD) with TDP-43 pathology (FTD-TDP). Progranulin-boosting therapies are a …
Posted May 21, 2026
Treating colon cancer by regulating intestinal immunity through microbial metabolism
US · IL NIH · grant
PROJECT SUMMARY Colorectal cancer (CRC) is profoundly affected by the intestinal immune system and the intestinal microbiome, which can exert both pro- and anti-cancer effects that operate alongside cell-intrinsic mutational events. Immune …
Posted May 21, 2026
Engineered probiotic bacteria for colorectal cancer immunoprevention and interception
US National Cancer Institute · grant
PROJECT SUMMARY Synthetic biology is driving a new era of medicine through the genetic programming of living cells. One particular focus has been the engineering of bacteria as therapeutic delivery systems to selectively release therapeutic…
Posted May 21, 2026
Modulating the localization and persistence of microbial neoantigen vaccine vectors to enhance therapeutic efficacy
US National Cancer Institute · grant
PROJECT SUMMARY The development of neoantigen cancer vaccines is transforming cancer immunotherapy – providing an approach to stimulate pre-existing and de novo anti-tumor T cell responses. These vaccines are designed to introduce tumor-spe…
Posted May 21, 2026
Dynamic reprogramming of macrophage acetyl-CoA metabolism in endotoxin tolerance
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Macrophages play a pivotal role in maintaining homeostasis by tightly regulating the inflammatory response. In response to endotoxins like lipopolysaccharide, they undergo dynamic reprogramming, transitioning from…
Posted May 21, 2026
A Novel RAD51-BRCA2 Complex Stabilizing Drug: A Medical Countermeasure for Mitigating Accidental Radiation Exposure
US · IL National Institutes of Health (NIH) · grant
Abstract Ionizing radiation (IR) exposure from accidents or warfare can cause severe damage to radiosensitive tissues, such as bone marrow, intestines, and blood vessels, leading to acute radiation syndrome (ARS) and delayed effects of acut…
Posted May 21, 2026
Phytotherapy for Endometriosis
US · IL NIH RePORTER · grant
ABSTRACT/SUMMARY Endometriosis is an inflammatory gynecological disease of reproductive-age women. The two major symptoms are chronic pelvic pain and infertility, which profoundly affect reproductive health and life quality. The pro- inflam…
Posted May 21, 2026
State of the Science Meeting Series: Health and Safety of Gulf Coast and U.S. Caribbean Fishers
US · IL National Institutes of Health (NIH) · grant
The objective of the proposed State of the Science Meeting Series: Health and Safety of Gulf Coast and U.S. Caribbean Fishers reflects an integrated, multi-disciplinary collaboration focused on evidence informed education bridging the gap b…
Posted May 21, 2026
Validation of blood-based predictive biomarkers of therapeutic response to neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Neoadjuvant chemoradiation therapy (nCRT) followed by surgery is the standard of care for patients with locally advanced rectal cancer (LARC), which accounts for ~60% of newly diagnosed rectal cancer cases. Althoug…
Posted May 21, 2026
New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial Fibrillation
US · IL NIH · grant
PROJECT SUMMARY Atrial fibrillation (AF) is the most common heart rhythm disorder that affects >3 million Americans and is a major cause of stroke. Since AF is primarily an age-related disease, it is fast becoming an epidemic in a rapidly a…
Posted May 21, 2026
Signaling mechanisms that modulate uterine 3D structure for pregnancy success
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT Although much is known about the embryo during early development, the structural uterine environment in which the early embryo develops is not well understood. A poor uterine environment at the time of blastocyst e…
Posted May 21, 2026
Chemistry-Biology Interface Predoctoral Training Program
US National Institute of General Medical Sciences · grant
Project Summary This proposal requests funds to support predoctoral trainees as part of the Chemical Biology Interface Training Program (CBITP) at New York University (NYU). Our program will catalyze interdisciplinary education at the inter…
Posted May 21, 2026
Biomolecular Recognition with Synthetic Protein Mimics
US · IL NIH · grant
Abstract Interactions of proteins with other biomolecules regulate fundamental cellular events and misregulation of these interactions leads to disease states. Proteins often utilize small folded domains for recognition of other biomolecule…
Posted May 21, 2026
The Effects of Neprilysin Inhibition on Cardiometabolic Health in Black Individuals
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Black individuals have a higher prevalence of insulin resistance and are more likely to have cardiometabolic diseases, which is associated with an increased risk of mortality. The reasons for the increased insulin resistance…
Posted May 21, 2026
Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure
US · IL NIH · grant
PROJECT SUMMARY Non-dipping type of nocturnal blood pressure (BP) is common even among treated hypertensives and is associated with a nearly two-fold higher risk of adverse cardiovascular events. Obesity impacts nearly 40% of American adult…
Posted May 21, 2026
Mentored Patient-Oriented Research in Natriuretic Peptide System Based Precision Cardiometabolic Health
US · AL NIH · grant
PROJECT SUMMARY Dr. Pankaj Arora is an Associate Professor of Medicine (Tenured), the Director of the Cardiovascular Genomics Clinic, and the Director of the Clinical and Translational Research Program at the University of Alabama at Birmin…
Posted May 21, 2026
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY The cardiometabolic disease burden is increasing in the United States. The atrial natriuretic peptide (ANP) hormone contributes to the regulation of glucose utilization, energy homeostasis and is a major determinant of cardi…
Posted May 21, 2026
Clinical Implementation of Blood Pressure Polygenic Risk Score: A Randomized Clinical Trial
US · IL NIH · grant
    Elevated blood pressure (BP) is the single greatest modifiable contributor to premature mortality globally. The development of hypertension (HTN) and associated adverse cardiovascular (CV) events is contributed by an interplay of geneti…
Posted May 21, 2026
Mount Sinai HHEAR Network Untargeted Lab Hub
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY/ABSTRACT FOR OVERALL The Icahn School of Medicine at Mount Sinai will leverage our research expertise in environmental epidemiology, analytical chemistry and clinical practice to renew our Human Health Exposure Analysis Reso…
Posted May 21, 2026
Integrated Health Sciences Facility Core
US · IL Mount Sinai Center on Health and Environment Across the LifeSpan (HEALS) · NAICS 541715 · grant
Project Summary (IHSFC) The mission of the Mount Sinai Center on Health and Environment Across the LifeSpan (HEALS) is to promote team-based environmental health science (EHS) research that embraces the developmental origins of health an…
Posted May 21, 2026
Early Warning Systems for Childhood and Adult Disorders
US · IL NIH · grant
Project Summary According to the developmental origins of health and disease hypothesis, many disorders originate via environmental exposures in fetal and early postnatal life. Such early life environmental exposures can alter the developme…
Posted May 21, 2026
Organic-metal mixtures and neurodevelopment
US National Institute of Environmental Health Sciences · grant
Project Summary The study of chemical mixtures is a high priority as mixtures represent the real-life exposure scenarios that impact health. Mixtures are methodologically similar to studying the exposome (i.e. the study of all health releva…
Posted May 21, 2026
SARS-CoV-2 Virology Core
US · IL National Institute of Allergy and Infectious Diseases · grant
Viruses of the Coronaviridae family are enveloped viruses that possess a large (30kb), single-stranded, positive sense, RNA genome that infect a large number of mammals (alpha and beta coronaviruses) and birds (gamma coronaviruses). Four di…
Posted May 21, 2026
Rise-HP: Reimagining Interventions for Support and Education in Hypersensitivity Pneumonitis; A Stakeholder Engaged Intervention to Improve Health-Related Quality of Life
US National Heart Lung and Blood Institute · grant
Project Summary/Abstract Hypersensitivity Pneumonitis (HP) is an often incurable and potentially progressive fibrotic interstitial lung disease (ILD) with limited treatment options that leads to poor health-related quality of life (HRQOL). …
Posted May 21, 2026