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Advancing Global Health
Bureau of Global Health Security and Diplomacy
GRANT
Due Feb 14
Advancing Global Health
Bureau of Global Health Security and Diplomacy (DOS-GHSD)
GRANT

Advancing Global Health

$unknown
Due Feb 14
Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells
National Institute of Environmental Health Sciences
GRANT

The elegant organization of nucleic acids, predominantly DNA, into chromatin serves essential structural and regulatory roles in eukaryotic cells. This beautiful architecture allows for an expansion o

Loyola-Ukrainian Catholic University International Bioethics Research Training Program
John E. Fogarty International Center for Advanced Study in the Health Sciences
GRANT

Project Summary/Abstract The Loyola University Chicago-Ukrainian Catholic University (LUC-UCU) Doctoral and Post- Doctoral Bioethics Training Program will provide advanced doctoral-level education in

The Effectiveness of Automated Multimodal Imaging in High Grade Squamous Intraepithelial Lesions (HSIL) Diagnosis for People Living with HIV: An International Trial
National Cancer Institute
GRANT

Abstract: Squamous cell cancer of the anus (SCCA) is increasing in the aging cohort of people living with HIV (PWH), who are at 40-80x higher risk for SCCA than the general population. The increase in

Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyaviruses
National Institute of Allergy and Infectious Diseases
GRANT

Summary: Bunyaviruses (Order: Bunyavirales) are a growing and diverse family of animal and human pathogens with pandemic potential. With over 300 members and an expanding distribution of mosquito and

Biochemical and structural mechanisms at the filoviral-host interface
National Institute of Allergy and Infectious Diseases
GRANT

RP01 Project Summary/Abstract for Biochemical and structural mechanisms at the filoviral-host interface The recent filoviral outbreaks, including the 2013-2016 Ebola virus (EBOV) outbreak in West Afri

Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyaviruses
National Institute of Allergy and Infectious Diseases
GRANT

Project Summary/Abstract Bunyaviruses (Order: Bunyavirales) are a growing and diverse family of animal and human pathogens with pandemic potential. With over 300 members and an expanding distribution

Gut pathogen virulence and its therapeutic modulation during surgical injury
National Institute of General Medical Sciences
GRANT

1 We demonstrated in both mice and critically ill humans, that following surgical injury/infection, the gut 2 microbiota collapse in structure, membership and function (i.e., production of health-rel

Investigating the link between pericyte dysfunction and loss of glucose homeostasis in COVID-19
National Institute of Diabetes and Digestive and Kidney Diseases
GRANT

ABSTRACT The coronavirus disease 2019 (COVID-19) is a global healthcare crisis that in the USA kills about 1 person every minute. It is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (S

Antigen presentation during Trypanosoma cruzi infection: in search of a new effective vaccine
National Institute of Allergy and Infectious Diseases
GRANT

PROJECT SUMMARY/ABSTRACT Chagas disease, caused by the parasite Trypanosoma cruzi, is a significant global health concern, primarily affecting Latin America but also impacting regions in Europe and th

Unraveling the spectrum of intrabacterial amide hydrolysis to develop new classes of pyrazinoic acid prodrugs against pyrazinamide resistant Mycobacterium tuberculosis
National Institute of Allergy and Infectious Diseases
GRANT

ABSTRACT Mycobacterium tuberculosis (Mtb) infection is a global health pandemic claiming 1.5 million lives each year. Current tuberculosis (TB) therapies are challenged by drug resistance, characteri

Lead Optimization and Preclinical Development of a small molecule inhibitor of M. avium KasA
National Institute of Allergy and Infectious Diseases
GRANT

ABSTRACT. Non-tuberculous mycobacteria (NTM) constitute a major threat to global health with over 200,000 annual cases in the United States alone. Mycobacterium avium complex (MAC) infections are the

Vanderbilt-Nigeria Research Ethics Training Program (V-NET)
John E. Fogarty International Center for Advanced Study in the Health Sciences
GRANT

Project Summary Abstract To address the increasing demand for research in precision medicine in Africa, the proposed Vanderbilt- Nigeria Research Ethics Training Program (V-NET) is an innovative resea

Vanderbilt-Nigeria Research Ethics Training Program (V-NET)
John E. Fogarty International Center for Advanced Study in the Health Sciences
GRANT

Project Summary Abstract To address the increasing demand for research in precision medicine in Africa, the proposed Vanderbilt- Nigeria Research Ethics Training Program (V-NET) is an innovative resea

Vanderbilt-Nigeria Research Ethics Training Program (V-NET)
John E. Fogarty International Center for Advanced Study in the Health Sciences
GRANT

Project Summary Abstract To address the increasing demand for research in precision medicine in Africa, the proposed Vanderbilt- Nigeria Research Ethics Training Program (V-NET) is an innovative resea

Decentralizing Breast Biopsy Procedures for Early Cancer Diagnosis In Rwanda
John E. Fogarty International Center for Advanced Study in the Health Sciences
GRANT

PROJECTS SUMMARY/ABSTRACT BACKGROUND: With 2.3 million new cases per year, breast cancer is among the most diagnosed cancers in women globally and is the leading cause of cancer mortality in low-and m

STTR Phase I: A Novel Biosensing Device for Rapidly Mapping Volumetric Tumor Margins
NSF
GRANT

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is a novel sensor to better detect tumor margins during surgical interventions for cancer. Can

CAREER: Investigating the role of the aeromicrobiological pathway in the development and spread of antimicrobial resistance
NSF
GRANT

Bacteria can evolve and become resistant to antibiotics that are used to treat infections. Antibiotic resistance is a serious global health challenge and is a factor in millions of deaths each year.

Nef in impaired efferocytosis: a novel mechanism for vascular disease in HIV
National Heart Lung and Blood Institute
GRANT

Project Summary Anti-retroviral therapy (ART) has protected many HIV patients against the development of AIDS. HIV infection has become a treatable disease. Increased risk for atherosclerotic vascular

Estimating the Seroincidence of Melioidosis, Typhoid Fever and Scrub Typhus from Cross-sectional Serosurveys
John E. Fogarty International Center for Advanced Study in the Health Sciences
GRANT

SUMMARY/ABSTRACT This mentored International Research Scientist Development Award (K01) from UC Davis and Mahidol University-Thailand will support Dr. Kristen Aiemjoy, Assistant Professor of Epidemiol

Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's Disease
National Institute on Aging
GRANT

Abstract Alzheimer's disease (AD) and other age-related neurodegenerative disorders have become a global health and social challenge. Although the exact cause of AD is still under investigation, among

Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's Disease
National Institute on Aging
GRANT

Abstract Alzheimer's disease (AD) and other age-related neurodegenerative disorders have become a global health and social challenge. Although the exact cause of AD is still under investigation, among

Heart Failure Polypill in India: A Late-Stage Implementation Strategy
National Heart Lung and Blood Institute
GRANT

PROJECT SUMMARY/ABSTRACT Heart failure (HF) is a leading global public health problem. The burden of HF is increasing in low- and middle- income countries and clinical outcomes remain poor. Guideline-

Heart Failure Polypill in India: A Late-Stage Implementation Strategy
National Heart Lung and Blood Institute
GRANT

PROJECT SUMMARY/ABSTRACT Heart failure (HF) is a leading global public health problem. The burden of HF is increasing in low- and middle- income countries and clinical outcomes remain poor. Guideline-

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