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Showing 25 / 21760 · page 27/871
Project 1: Immunogen Design and Delivery
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT The development of an effective HIV vaccine remains a major challenge. Previous strategies for HIV vaccine design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutralizing antibo…
Posted May 21, 2026
Rationally designed targeted immunogens to elicit HIV Envelope V2-apex broadly neutralizing antibodies
US National Institute of Allergy and Infectious Diseases · grant
OVERALL: PROJECT SUMMARY Our primary goal in this IPCAVD program is to develop a germline-targeting priming immunogen for the HIV Envelope V2-apex broadly neutralizing antibody (bnAb) site. We aim to test its ability to activate V2-apex bnA…
Posted May 21, 2026
Development of pan-betacoronavirus vaccines
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus identified at the end of 2019, has led to the current global pandemic. The SARS-CoV-2 virus belongs to the subgenus sarbecovirus of t…
Posted May 21, 2026
Combining germline-targeting, B cell immunofocusing and Env-Ab coevolution strategies to induce HIV Envelope V2-apex broadly neutralizing antibodies
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT: The development of an effective HIV vaccine has proven to be a daunting challenge. Previous strategies for HIV vaccine design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutra…
Posted May 21, 2026
Investigation and application of hydrocarbon-degrading enzymes using cryo-electron microscopy and directed evolution
US · IL National Institutes of Health (NIH) · grant
Glycyl radical enzymes (GREs) are a growing superfamily that catalyzes an impressive array of chemical transformations critical to human health. GREs share a common glycyl radical cofactor, which allows them to perform challenging, otherwis…
Posted May 21, 2026
Engineering radical enzymes for asymmetric olefin hydroalkylation
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY: The synthesis of biologically active molecules through selective C–C bond-forming reactions is central to the discovery of new therapeutics. Though forging C–C bonds is often more challenging at C(sp3)-centers than C(sp2)-c…
Posted May 21, 2026
Simplifying the transformation of laboratory test data for integration into the ImmPort database
US · IL NIH/NIAID · grant
Project Summary/Abstract The sharing of data in biomedical research, including data generated from clinical trials, is paramount for ensuring reproducibility, improving study design, increasing analytic power via concatenation of disparate …
Posted May 21, 2026
Characterizing cytotoxic therapy induced shifts in the cost-to-benefit ratio of high ploidy
US National Cancer Institute · grant
SUMMARY Traditional phase I dose-finding strategies monitor drug response only for two weeks, based on the assumption that it will suffice to observe how therapy affects doubling time of a homogeneous population over 2-4 generations. But with …
Posted May 21, 2026
The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis
US · IL NIH · grant
Abstract Exercise training is linked to beneficial effects on maladaptive immune aging. In patients with rheumatoid arthritis (RA), exercise training is a disease modulating therapy and may improve premature biological aging inherent in RA,…
Posted May 21, 2026
Protein Allostery and Catalysis Beyond Bragg Diffraction
US · IL NIH · grant
Abstract The central goal of this project is to understand how protein motion gives rise to function. However, visualizing proteins in motion is a problem that is inherently difficult in structural biology as it involves signals from many c…
Posted May 21, 2026
Deciphering the role of junctional adhesion molecule-A in neutrophil-driven inflammatory response in Alzheimer disease
US · IL NIH · grant
Accumulating evidence suggests that Alzheimer’s disease (AD)-related inflammation progresses in two different but interrelated compartments: the blood and the brain, implying that leukocytes could lead to “brain activation,” while brain inf…
Posted May 21, 2026
DP21-001 Utah Pregnancy Risk Assessment Monitoring System (PRAMS)
US · UT Utah Department of Health · grant
Since 1999, the Utah Department of Health (UDOH) has conducted the Pregnancy Risk Assessment Monitoring System (PRAMS) survey to help improve understanding of maternal behaviors and their relationship to pregnancy outcomes and to develop po…
Posted May 21, 2026
Mapping spatiotemporal dynamics during enterovirus infection across cells and tissues
US · IL NIH · grant
Project Summary Human enterovirus (HEV) infections primarily affect infant and adolescent populations, causing a wide range of clinical manifestations that commonly include respiratory illness and mucocutaneous lesions, or hand, foot and mo…
Posted May 21, 2026
Elucidating the structural adaptation of HIV-1 capsids during critical host-factor interactions
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY The HIV-1 capsid provides a protective conical enclosure for the transport of the viral genome to its integration sites inside the nucleus. The capsid must uncoat to release the newly formed vDNA and to establish a permanent…
Posted May 21, 2026
Tracking Adverse prenatal Brain Stressors on offspring development (TABS)
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY A growing body of published research links heightened maternal psychological distress (MPD) during pregnancy to an increased risk of adverse outcomes for the pregnant mother herself as well as for her offspring, including im…
Posted May 21, 2026
Symbiotic-based discovery of turbinmicin, a safe and selective antifungal against resistant fungi
US · IL NIH · grant
New antifungal drugs are needed to address the emergence of pan-drug resistant fungal pathogens that threaten a growing immunocompromised patient population. Underscoring this urgency is the recent global spread of Candida auris, which is r…
Posted May 21, 2026
Vesicle-mediated drug resistance of Candida albicans biofilm
US · IL NIH · grant
Project Summary Candida commonly adhere to medical devices, flourishing as a biofilm. A clinical hallmark of biofilm infection is profound antifungal resistance. As effective therapies are not available for these life-threatening infections…
Posted May 21, 2026
High-speed, real-time feedback-driven single particle tracking with concurrent smFRET
US · IL NIH · grant
PROJECT SUMMARY: The goal of this project is to establish proof-of-concept for a new high speed, Real-Time Feedback-Driven Single Particle Tracking (RT-FD-SPT) fluorescence microscope with concurrent spectroscopic readout. The project is mot…
Posted May 21, 2026
Project 1: Mechanisms, Dynamics, and Prediction of Heteroresistance
US · IL NIH · grant
ABSTRACT Understanding antibiotic resistance mechanisms is critical to designing novel approaches and therapeutics to combat resistant bacteria. Heteroresistance (HR) is a bacterial phenotype in which an isolate contains a subpopulation of …
Posted May 21, 2026
Characterizing the Quality of Evidence-based Prescribing for Hospitalized Veterans
US Veterans Affairs · grant
Significance to VA: Each year, hundreds of thousands of Veterans are hospitalized for new presentations and acute exacerbations of complex chronic conditions, such as cardiovascular, pulmonary, neurologic, and substance use disorders. For e…
Posted May 21, 2026
Optimizing prescribing decisions for hospitalized older adults with chronic conditions
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Over 7 million adults ages 65 and older are hospitalized in the US annually, of whom two-thirds have multiple chronic conditions. Older adults are often discharged with changes to medications for chronic conditions,…
Posted May 21, 2026
Peaks to genes: Fine mapping of QTLs and functional analysis
US · IL NIH · grant
PROJECT SUMMARY Linkage mapping using genetic crosses results in identification of quantitative trait locus (QTL) regions that may contain tens to hundreds of genes. Identification of the causative genes therefore requires careful prioritiz…
Posted May 21, 2026
Genomic consequences of schistosome hybridization
US · IL NIH · grant
Hybridization between parasite species has the potential to transfer biomedically important genes across species boundaries with potential impact on host specificity, pathogenesis and drug resistance. It is widely assumed that there is freq…
Posted May 21, 2026
Mapping Drug Resistance Genes in Plasmodium falciparum
US · IL NIH · grant
ABSTRACT Drug resistance mutations disrupt key physiological processes resulting in severe fitness costs; compensatory mutations are expected to evolve to restore fitness. Such compensatory mutations are extensively studied in bacterial pat…
Posted May 21, 2026
Claustrum serotonin and spike-timing plasticity associated with cognitive deficits after cocaine
US · IL NIH · grant
Project Summary/Abstract Over 40 million individuals in the US have a substance use disorder (SUD), and therapies for treating SUD have remained largely inadequate for decades. One of the key challenges in SUD treatment is that many drugs o…
Posted May 21, 2026