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Showing 25 / 21760 · page 28/871
Linking mitochondrial and synaptic weakness to schizophrenia
US National Institute of Mental Health · grant
Schizophrenia (SZ) is a heterogenous neurodevelopmental disorder in which the complex and interacting influences of genetics and environment drive neuropathological processes leading to symptom development. While the precise neuropathologic…
Posted May 21, 2026
Molecular Studies of Cellular Cytotoxicity
US · IL NIH · grant
The overarching goal of this research program is the investigation of the innate immune system with a primary focus on natural killer (NK) cells and their use in the treatment of cancer. Our group has been a globally recognized leader in th…
Posted May 21, 2026
NHGRI/DIR Flow Cytometry Core
US National Human Genome Research Institute · grant
The Flow Cytometry Core of the National Human Genome Research Institute has the goal of providing all NHGRI investigators access to high quality flow cytometry services that enhance the scope and breadth of their scientific research. Servic…
Posted May 21, 2026
Formative Research on How Faith Communities can Promote Lung Cancer Screening
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Black or African American men experience the highest lung cancer incidence (60.6 per 100,000 people) and mortality rates (45.7 per 100,000 people) compared to any other racial/ethnic group of both men and women and …
Posted May 21, 2026
Establishing the neuropathologic and molecular features of a spontaneous canine model of peripheral neuropathy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY/ABSTRACT Hereditary peripheral neuropathies (HPNs) are common disorders that involve degeneration of nerves in the peripheral nervous system. Common clinical signs include progressive muscle weakness, foot deformities, and s…
Posted May 21, 2026
BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Targeting metabolism to accelerate recovery from disuse atrophy in aged mice
US · IL Department of Veterans Affairs · NAICS 541714 · grant
Older Veterans have a greater burden of multi-morbidity compared to the general population, resulting in frequent and re-occurring inpatient hospitalizations. The inability to recover from hospital acquired muscle weakness is linked to hosp…
Posted May 21, 2026
Molecular Networks in Aging and Caloric Restriction in Rhesus Monkeys
US · IL NIH · grant
SUMMARY Age is the greatest risk factor for a host of chronic diseases, including cancer, diabetes, cardiovascular disease and neurodegeneration. The mechanistic basis for this shared risk and its continued increase as a function of age is…
Posted May 21, 2026
Wisconsin Nathan Shock Center
US National Institute on Aging · grant
Abstract Overall The goal of the Wisconsin Nathan Shock Center (WiNSC) is to catalyze research at the interface of aging, metabolism, and translation, building an environment and infrastructure that will have a significant impact locally an…
Posted May 21, 2026
Novel Gene Therapy, Techniques, and Devices to Prevent Ventricular Tachycardia
US National Heart Lung and Blood Institute · grant
ABSTRACT In the United States, several hundred thousand people experience cardiac arrest each year, with the vast majority dying from this condition. Approximately two-thirds of cardiac arrest victims have previously suffered a myocardial …
Posted May 21, 2026
Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor Progression
US National Cancer Institute · grant
PROJECT SUMMARY: 30 lines. The canonical phosphoinositide (PI) 3-kinase (PI3K)/Akt signaling pathway uses free membrane PI lipid to regulate cell growth and is frequently hyperactivated in cancer. Akt is also activated in the nucleus by poo…
Posted May 21, 2026
Phosphoinositide Signaling in Cytosol and Nucleus
US · IL NIH · grant
Project Summary The research proposed seeks to reveal mechanisms for spatial phosphoinositide (PI) signaling in the cytosol and nucleus. These pathways have broad implications for cancer, neurodegenerative disorders, and other diseases. PI …
Posted May 21, 2026
Determine the role of a monocarboxylate transporter in metabolism and intestinal motility
US · IL NIH · grant
PROJECT SUMMARY Monocarboxylate transporters (MCTs) mediate the transport of key metabolic intermediates, such as lactate, urate, and pyruvate, across cellular membranes. Despite their importance in metabolic homeostasis and their implicati…
Posted May 21, 2026
A platform for monitoring the efficacy and optimal dosing of long-acting ART
US · IL NIH · grant
Project Summary/Abstract The rapidly emerging modalities of long-acting antiretroviral therapy (ART) for treatment and prevention are based on a one-size-fits-all dosing strategy despite these being our first experiences in real-world sett…
Posted May 21, 2026
Advanced body composition imaging to improve outcomes in lung transplantation
US · IL NIH RePORTER · grant
PROJECT SUMMARY Median survival after lung transplantation (Tx) is only 6.7 years, compared to >11 years after other solid organ Tx. Obesity increases risk of death on the Tx waitlist, early severe lung injury (primary graft dysfunction, PG…
Posted May 21, 2026
Anticodon Engineered tRNA for the Treatment of Hereditary Eye Disease
US National Eye Institute · grant
Summary Nonsense mutations are point mutations that convert an amino acid encoding codon into a premature termination codon (PTC). The consequences of PTCs are nonsense-mediated mRNA decay, and for transcripts that persist, premature transl…
Posted May 21, 2026
Rodent Phenotyping Core
US National Eye Institute · grant
PROJECT SUMMARY The goal of the Rodent Phenotyping Core (RPC) is to increase the utility of mice and rats as model organisms for vision research at The University of Iowa. The availability of a centralized core for phenotyping will allow in…
Posted May 21, 2026
Foundational Biology of Glaucoma GWAS Loci
US National Eye Institute · grant
Abstract Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. Damage from glaucoma is permanent and may cause irreversible blindness. Glaucoma is a major public health problem in th…
Posted May 21, 2026
Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT In partnership with Deaf-owned agency National Deaf Therapy (NDT), we propose the first-ever full-scale psychotherapy trial conducted in the Deaf community. The U.S. Deaf community – more than 500,000 Americans who …
Posted May 21, 2026
E. coli virulence gene expression during clinical UTIs in women
US National Institute of Allergy and Infectious Diseases · grant
To understand the pathogenesis of urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC), it is critical to both follow up on our determination of the transcriptional program enacted by UPEC during uncomplicated UTI…
Posted May 21, 2026
Tuning peptide specifities for T cell tolerance in Type 1 diabetes
US · IL NIH · grant
Project Summary/Abstract Type 1 Diabetes (T1D) is a classical T-cell mediated autoimmune disease and substantial data implicates insulin as a dominant autoantigen in T1D disease. In the NOD mouse model of T1D, notable studies have shown th…
Posted May 21, 2026
Thymic medullary epithelial cell turnover and control of immune tolerance
US · IL NIH · grant
A normal and robust immune system relies on the development of a diverse repertoire of T cells that are tolerant of self- tissues. The thymus is a critical site for the development and education of T cell to promote tolerance to self and th…
Posted May 21, 2026
Alterations of leukocyte integrin signaling leading to diabetes and autoimmunity
US · IL NIH · grant
Project Summary/Abstract The study of the genetic basis for type 1 diabetes (T1D) has benefited tremendously from examination of rare individuals with likely monogenic forms of the disease. Combined with GWAS, a number of polymorphisms in i…
Posted May 21, 2026
STAT3 variants as a rheostat of immune tolerance
US · IL NIH · grant
Project Summary/Abstract (Overall) Dysregulation of the immune system can have severe consequences on health and wellbeing. Although this is often a complex process, recent progress in human genetics has allowed for the identification of si…
Posted May 21, 2026
UCSF Type 1 Diabetes Research Center
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Overall Summary The University of California at San Francisco Diabetes Research Center (DRC) will function as a basic and clinical research enterprise at the forefront of type 1 diabetes (T1D) research. The DRC crosses the boundaries of Dep…
Posted May 21, 2026
The RSELVES Study: Remote Sensing of (older adult partners') Engagement in Life and Variability in Everyday Support
US · IL NIH · grant
PROJECT SUMMARY Alzheimer’s disease is a leading cause of functional disability among older adults worldwide. Despite the inevitability of functional impairment in Alzheimer’s disease, large heterogeneity in the rate and order that specific…
Posted May 21, 2026