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Showing 25 / 21760 · page 37/871
Elucidating the Role of C16orf72 in the Cellular Stress Response Network
US · IL NIH · grant
PROJECT SUMMARY A hallmark of cancer is the ability of malignant cells to maintain viability in the face of stressors such as aneuploidy, nutrient scarcity, and xenobiotic compounds. This multi-stress-resilience phenotype enables tumor form…
Posted May 21, 2026
Capacity building for timely diagnosis of Multiple Sclerosis and prevention of disability
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
Abstract This application proposes to address priority areas for improvement in the care of multiple sclerosis (MS) in Colombia (a low-middle income country), which is a country with a population that is ancestrally and genetically diverse…
Posted May 21, 2026
Prenatal Exposure to Organophosphate Ester Flame Retardants and Plasticizers (OPEs), Gene-Environment Interaction, and Child Neurodevelopment
US · IL NIH · grant
ABSTRACT The prevalence of autism and attention-deficit/hyperactivity disorder (ADHD) is increasing, yet their etiology is poorly understood. A complex combination of environmental and genetic factors appears to contribute to both condition…
Posted May 21, 2026
Interactions of Environmental Chemical Mixtures, Genetics, and Immune Pathways in Autism Spectrum Disorder
US National Institute of Environmental Health Sciences · grant
ABSTRACT The rising prevalence of Autism Spectrum Disorder (ASD) among children is a public health concern. An expanding landscape of genetic and environmental risk factors has been implicated in ASD’s development, indicating complex, multi…
Posted May 21, 2026
A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment
US National Institutes of Health (NIH) · grant
The proposed Career Development Award (CDA-2) would support Dr. Victoria Ameral, Clinical Research Psychologist with the VISN 1 New England Mental Illness Research, Education, and Clinical Center (MIRECC) and recent graduate of the VA Inter…
Posted May 21, 2026
THE ROLE OF THE NON-CANONICAL INFLAMMASOME IN INNATE IMMUNITY
US · IL NIH RePORTER · grant
ABSTRACT Legionella pneumophila is an infectious bacterium that causes Legionnaire’s disease and remains a major cause of morbidity and mortality in the immunocompromised individuals such as the elderly and cancer patients. Macrophages are …
Posted May 21, 2026
Targeting specific MicroRNA to alleviate Alzheimer’s Disease pathobiology
US · IL NIH · NAICS 541714 · grant
Targeting microglia to alleviate Alzheimer’s Disease pathobiology Summary Alzheimer’s disease (AD) is the most common cause of age-related dementia leading to irreversible neurodegeneration and cognitive decline with no cure or effective pr…
Posted May 21, 2026
Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
US · IL NIH · grant
OVERALL - ABSTRACT COVID-19 is a world-wide health problem caused by SARS-CoV-2 viral infection in the lung with long-term symptoms in at least one third of patients. Many COVID-19 patients suffer from silent or identified thrombi in major …
Posted May 21, 2026
Quantifying cerebellar multi-omic and synaptic features of autism spectrum disorders
US National Institute of Mental Health · grant
Project Summary Strong, longstanding evidence points to important roles for the cerebellum in autism spectrum disorders (ASDs), yet cerebellar mechanisms remain understudied in ASDs compared to neocortical circuits. Anatomical and functiona…
Posted May 21, 2026
Multi-scale consequences of variants in the schizophrenia risk gene SETD1A in a population isolate.
US · IL NIH · grant
Project Summary. Rare variants with large effects provide excellent opportunities to characterize causal mechanisms for complex disorders. Recently, large-scale exome sequencing of schizophrenia found that rare protein-truncating and missen…
Posted May 21, 2026
Irx1 regulation of oral tissue repair and maintenance.
US National Institute of Dental and Craniofacial Research · grant
Project Summary Oral disease causes a significant burden on overall health and 3.9 billion people are affected worldwide. Oral diseases such as periodontitis, cancer, tooth loss, craniofacial birth defects and pain all affect growth and ma…
Posted May 21, 2026
Integrative Center for Environmental Microbiomes and Human Health
US National Institute of General Medical Sciences · grant
Project Summary – OVERALL We seek to strengthen and enhance the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH). Our center was established in response to the 2016 announcement of the National Microbiome Initiativ…
Posted May 21, 2026
Role of CRTC1-MAML2 in Salivary Mucoepidermoid Carcinoma Pathobiology
US National Institute of Dental and Craniofacial Research · grant
Summary Mucoepidermoid carcinomas (MEC) are the most common type of malignant salivary gland tumor (SGT) with advanced MEC often being fatal due to resistance to conventional therapies. Despite their prevalence in salivary malignancies and …
Posted May 21, 2026
Leveraging Data Science Applications to Improve Children's Environmental Health in Sub-Saharan Africa (DICE)
US National Institute of Environmental Health Sciences · grant
Project Abstract Poor environmental conditions such as air pollution, and unsafe water and sanitation have been ranked among the top risk factors for disability-adjusted years (DALYs) in children. The highest number of deaths per capita att…
Posted May 21, 2026
Telemetric Regenerative Bandage for Accelerating Wound Healing
US · IL NIH · grant
Summary Diabetic foot ulcers (DFUs) are a major complication of diabetes. These sores, if left untreated, can become infected and become a serious threat to the patient’s well being. Although the field of wound care management is well estab…
Posted May 21, 2026
Low-Profile 3D-Printed Radiopaque Bioresorbable Vascular Scaffolds
US · IL NIH · grant
PROJECT SUMMARY Atherosclerotic coronary artery disease (CAD) and peripheral artery disease (PAD) are responsible for significant morbidity, mortality, and high healthcare costs in the USA. This problem will continue to grow due to the dia…
Posted May 21, 2026
Regenerative Engineering Training Program (RE-Training)
US National Institute of Biomedical Imaging and Bioengineering · grant
Summary for the Regenerative Engineering Training Program A major health challenge that our society faces is premature death and morbidity associated with the shortage of healthy donor tissues or organs for transplantation and the limited r…
Posted May 21, 2026
Developing a SMART scaffold for bladder augmentation
US · IL NIH · grant
SUMMARY Each year in the United States there are 14,000 bladder augmentation enterocystoplasty surgeries to address trauma, urological cancers, severe cases of spina bifida, and interstitial cystitis. Although enterocystoplasty is the stand…
Posted May 21, 2026
Biochemical Analysis of Multidrug Resistance-linked Transport Proteins
US National Cancer Institute · grant
Clinical resistance to multiple chemically and functionally dissimilar drugs is multifaceted. P-glycoprotein (P-gp, ABCB1) and ABCG2 appear to contribute to this problem due to their broad and overlapping substrate specificities. Both trans…
Posted May 21, 2026
Molecular Mechanisms Regulating Calcium Flux In Salivary Glands
US National Institute of Dental and Craniofacial Research · grant
Research Advances Our key findings in this fiscal year are as follows: 1.STIM proteins, STIM1 and STIM2, play important roles in the activation of store-operated calcium entry (SOCE) through their interaction with the plasma membrane Ca2+…
Posted May 21, 2026
Novel Markers for Disease Outcome in Breast Cancer
US · IL NIH · grant
Project 1: The mechanisms through which chronic stressors may be associated with tumor biologic characteristics, immune response, and health disparities remain insufficiently understood. Hence, we investigated the proteomic, transcriptomic,…
Posted May 21, 2026
Maryland Prostate Cancer Case-Control Study
US · MD · Baltimore NIH · grant
Our study was implemented in two phases. The first phase, which started in April of 2005, constituted a pilot study to evaluate recruitment procedures. This phase was successful, and the full study was initiated with minor changes to the pr…
Posted May 21, 2026
The Molecular Profile of Prostate Tumors in African-American Men
US · IL NIH · grant
Currently, genomic risk, including genetic ancestry-inferred risk, is considered a nonmodifiable risk factor. Previous studies have shown that West African genetic ancestry is linked to increased prostate cancer risk among Black men, whose …
Posted May 21, 2026
Harnessing Artificial Intelligence and Deep Learning to Determine a Coronary Artery Calcium Estimate in Patients with No History of AtheroSclerotic CardioVascular Disease (HIDDEN-ASCVD) Study
US · IL NIH · grant
PROJECT SUMMARY/ ABSTRACT Data science advances have led to the emergence of opportunistic imaging screening – applying algorithms to screen for conditions from imaging performed for other purposes. Opportunistic screening for coronary arte…
Posted May 21, 2026
Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting
US National Cancer Institute · grant
ABSTRACT Immune checkpoint inhibitors (ICIs) are a powerful and innovative mode of cancer therapy, believed to be partially responsible for the largest single-year drop in cancer mortality from 2016 to 2017. Their use has increased dramatic…
Posted May 21, 2026