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Showing 25 / 21760 · page 38/871
2/2 PROmote weight loss in obese PAD patients to preVEnt mobility loss: The PROVE Trial--DCC
US · IL NIH · grant
The PROVE Trial DCC Project Summary This U24 application from the Wake Forest School of Medicine (WFSM) describes plans by experienced inves- tigators and staff to serve as the Data Coordinating Center (DCC) for the PROmote weight loss in o…
Posted May 21, 2026
2/2 Improving Mobility After Revascularization in Peripheral Artery Disease: The IMPACT PAD Trial
US · IL NIH · grant
The IMPACT PAD Trial DCC Project Summary This U24 application from the Wake Forest University School of Medicine (WFUSM) describes plans by expe- rienced investigators and staff to serve as the data coordinating center (DCC) for the IMProvi…
Posted May 21, 2026
Sex Dimorphism in Age-Related Knee Osteoarthritis
US · IL NIH RePORTER · grant
As indicated by the 2019 Global Burden of Disease Study, although women, on average, have a longer lifespan than men, women typically experience worsened health outcomes as they age. Notably, postmenopausal women have a higher incidence of …
Posted May 21, 2026
The opposing effects of matrix aging and muscle activity on extracellular vesicle promotion of muscle regeneration
US · IL NIH · grant
ABSTRACT Young skeletal muscle displays remarkable resilience following an acute injury event, evidenced by a robust regenerative response and functional recovery. In contrast, even a relatively minor injury to aged muscle can result in si…
Posted May 21, 2026
Innovations in Myogenesis: From Molecular Mechanisms to Therapeutic Interventions
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. The goal of the Frontiers in Myogenesis meeting – Innovations in Myogenesis: From Molecular Mechanisms to T…
Posted May 21, 2026
Genetic information flow in the Hallmarks of Aging: from system-level analytics to mechanistic interventions
US · IL NIH · grant
ABSTRACT Although aging is understood as a system-wide deterioration of cell and tissue function, it is nevertheless associated with specific hallmarks, first introduced by López-Otín et al. in 2013. Because these hallmarks have traditional…
Posted May 21, 2026
Deciphering the Role of Gut Microbiome in Inflammatory Bowel Disease Using a Canine Patient-Specific Gut-on-a-Chip
US · IL NIH ORIP · grant
PROJECT SUMMARY This NIH ORIP K01 award application describes a 5-year training plan designed to allow me to gain additional skill and knowledge so that I can transition to an independent R01-funded tenure track research scientist. In carry…
Posted May 21, 2026
Reversing Skeletal Aging by Restoring Functional Skeletal Stem Cell Diversity
US · IL NIH · grant
Advancing age is tightly linked to the increasing global incidence of skeletal diseases. Osteoporosis poses a major public health threat for over 54 million Americans as it is interrelated with high fracture rates. Osteoporosis related hip …
Posted May 21, 2026
Skeletal Stem Cell-based Cartilage Regeneration in Aged and Osteoarthritic Niches
US National Institute on Aging · grant
Project Summary Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of hyaline cartilage lining articular joints. A critical challenge for OA management is the development of an effective treatme…
Posted May 21, 2026
Deciphering HIV-1 Resistance Pathways against Capsid Inhibitors in vitro and in Humanized Mice
US · IL NIH · grant
PROJECT SUMMARY The HIV-1 capsid, a cone-shaped protein shell, is a promising target for antiviral interventions, with lenacapavir (LEN), a potent capsid inhibitor, demonstrating efficacy in treatment and prevention. However, resistance to …
Posted May 21, 2026
Genetic control of developmental timing
US · IL NIH · NAICS 541715 · grant
1 Project Summary/Abstract Development of even the simplest of multicellular animals is astonishingly complex, involving the spatial and temporal orchestration of cellular proliferation, differentiation, and morphogenesis throughout the de…
Posted May 21, 2026
Antibodies against Oxidized Phospholipids and Osteoporosis
US · IL NIH · NAICS 541714 · grant
Phosphatidylcholine is the most common phospholipid in cell membranes, microvesicles, and lipoproteins; it contains the phosphocholine head group (PC) and polyunsaturated fatty acids (PUFA) that are susceptible to lipid peroxidation by reac…
Posted May 21, 2026
Investigating the EBV methylome in PLWH: Discovery and Development of Novel EBV Diagnostics in Plasma and Saliva
US National Cancer Institute · grant
ABSTRACT EBV(+) lymphomas are an important cause of death in people living with HIV (PLWH). Different patterns of viral and cellular gene expression have been found to characterize different subtypes of EBV(+) lymphomas. CpG methylation of …
Posted May 21, 2026
Enrichment for Tumor-derived Cell-free EBV DNA: Towards a Diagnostic Assay for Endemic Burkitt Lymphoma
US National Cancer Institute · grant
PROJECT SUMMARY Endemic Burkitt lymphoma (eBL) outcomes in children with advanced stage disease are markedly inferior to those in children with early-stage disease. eBL is one of the most rapidly growing tumors. As a result, diagnostic del…
Posted May 21, 2026
Defining the role of SINE retrotransposons and inflammasome activation in Alzheimer's disease
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Pathological hallmarks of Alzheimer's disease (AD) include deposition of Amyloid-β (Aβ) plaques and accumulation of hyperphosphorylated Tau aggregates in neurofibrillary tangles. These aggregates have been demonstrated to ac…
Posted May 21, 2026
Cytosolic SINE retrotransposable element cDNA and mitochondrial DNA in aging retina
US · IL National Institutes of Health (NIH) · NAICS 541715 · grant
PROJECT SUMMARY The retinal pigmented epithelium (RPE) is an amitotic, long-lived cell type that supports healthy visual function for numerous decades. The aging retina displays pathologic features that are exaggerated in a complex disease …
Posted May 21, 2026
UAB Outcomes of Babies with Opioid Exposure (OBOE study)
US · AL NIH · grant
Project Summary Limited data are available on the effects of prenatal opioid exposure on the brain and neurodevelopment. The Outcomes of Babies with Opioid Exposure (OBOE) study, an ongoing NICHD-funded longitudinal study enrolling infants…
Posted May 21, 2026
UAB Clinical Site HEAL Neonatal Opioid Withdrawal Pharmacological Treatments
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary Many infants exposed to opioids antenatally develop Neonatal Opioid Withdrawal Syndrome (NOWS). The overarching goal of the HEAL Initiative: Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effecti…
Posted May 21, 2026
Vital Signs In Opioid-Exposed Neonates
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary Rates of opioid use during pregnancy are at epidemic proportions. Infants exposed to opioids before birth frequently develop neonatal opioid withdrawal syndrome (NOWS) and are at a much higher risk of sudden infant death sy…
Posted May 21, 2026
Let-7b in BPD
US · IL National Heart Lung and Blood Institute · grant
Project Summary Bronchopulmonary dysplasia (BPD) is common in extremely low birth weight (ELBW) infants. Recently, we discovered that the strongest biomarker signal was of microRNA let-7b-5p, with a 46-fold increase (p<0.001) at birth in t…
Posted May 21, 2026
Identifying the Role of the IL-6/STAT3 Signaling Pathway in Higher-risk Myelodysplastic Syndrome
US Veterans Affairs · grant
Myelodysplastic syndromes (MDS) are myeloid malignancies most commonly diagnosed at an advanced age. They are considered a spectrum of malignancies that can range from low to high grade and they are classified based on an international prog…
Posted May 21, 2026
Differential routing of valence information through the basolateral amygdala
US · IL National Institutes of Health (NIH) · grant
Project Summary Decision-making is critical for survival but is a complex process to understand at the level of brain function. Animals and humans alike can use two strategies to solve problems of decision-making: goal-directed or habitual…
Posted May 21, 2026
Cancer Biology Research Test-Bed Unit 1: Effects of cell-intrinsic and cell-extrinsic signaling and mechanics on metastasis patterns of pediatric sarcomas
US · IL NIH · grant
Ewing sarcoma, a malignant tumor of bone and soft tissue affecting children, adolescents, and young adults. For the one-third of Ewing sarcoma patients who develop metastasis, the long-term survival rate remains less than 30%. Decades of cl…
Posted May 21, 2026
Identifying non-human primate models for specific human microbiome traits
US NIH Office of the Director · grant
Abstract: The gut microbiota is increasingly recognized as an important contributor to a range of human physiological processes and is attracting increasing attention as a dynamic area for the development of therapeutics. To realize the pot…
Posted May 21, 2026
Defining the role of Sf1 in urethral closure
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Hypospadias is one of the most common birth defects in the world affecting nearly 1% of newborn boys. Hypospadias is the result of disrupted urethral closure where the urethra exits ventrally along the shaft of the penis. The etiology of 70…
Posted May 21, 2026