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Showing 25 / 21760 · page 39/871
Investigating the role of FOXL2 during urethra closure
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary Hypospadias is one of the most common birth defects in the world, affecting nearly 1% of newborn boys. Hypospadias is abnormal urethra closure, where the urethra exits ventrally along the shaft of the penis, and not the tip.…
Posted May 21, 2026
Multiscale Computational Microscopy of HIV-1
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT The human immunodeficiency virus 1 (HIV-1) is the RNA retrovirus that causes acquired immunodeficiency syndrome (AIDS), a disease that has killed over 40 million people worldwide and infected more than twice that. Continued high in…
Posted May 21, 2026
Developing a Single-Session Intervention to Support Adolescent Siblings of Children with Cancer
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Adolescent siblings of children with cancer are at-risk for psychological distress and report unmet needs in response to their sibling’s cancer diagnosis and treatment. However, most siblings do not have access to s…
Posted May 21, 2026
Identifying ancestry-specific and distal components of disease-associated gene regulation and cellular function
US · IL National Institutes of Health (NIH) · NAICS 541714 · grant
Summary/Abstract Genome-wide association studies (GWAS) have associated hundreds of thousands of genetic variants with human disease and complex traits. 90% of associated variants reside in noncoding sequences that can enhance or suppress g…
Posted May 21, 2026
Mechanotransduction mechanisms of ovarian aging
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Aging affects all tissues and is associated with functional deterioration. Each tissue has specific aging kinetics, and the female reproductive system is the first to age. Female reproductive aging is associated with a decrease in oocyte …
Posted May 21, 2026
Targeting autophagy to enhance immune checkpoint inhibition
US National Cancer Institute · grant
Project Summary – Project 2 A new approach that can overcome resistance to immune checkpoint inhibition (ICI) is a major unmet need for Stage IV melanoma patients. The overall goal of this project is to determine if combined ICI with autoph…
Posted May 21, 2026
Resistance mechanisms to autophagy-modulating therapies
US · IL NIH · grant
Project Summary Although targeted therapy and immune checkpoint inhibitors have made a major impact on survival for some patients with advanced cancer, the majority of patients do not respond to standard of care treatments. Abundant eviden…
Posted May 21, 2026
Identification and Characterization of Entry Factors Critical for Rift Valley Fever Virus Infection and Pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract Rift Valley fever virus (RVFV) is a phlebovirus that belongs to the Phenuiviridae (formerly Bunyaviridae) family of negative-sense RNA viruses. As an emerging mosquito-borne virus, the significance of RVFV is highli…
Posted May 21, 2026
Biochemical and structural mechanisms at the filoviral-host interface
US National Institute of Allergy and Infectious Diseases · grant
RP01 Project Summary/Abstract for Biochemical and structural mechanisms at the filoviral-host interface The recent filoviral outbreaks, including the 2013-2016 Ebola virus (EBOV) outbreak in West Africa that introduced the virus to other co…
Posted May 21, 2026
Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyaviruses
US National Institutes of Health (NIH) · grant
Project Summary/Abstract Bunyaviruses (Order: Bunyavirales) are a growing and diverse family of animal and human pathogens with pandemic potential. With over 300 members and an expanding distribution of mosquito and tick vectors due to clim…
Posted May 21, 2026
Promoting a Broad, Sustainable NIDDK-Supported Workforce through Mentoring Early Career Investigators: Focus on Health Outcomes
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Modified Project Summary/Abstract The broad, long-term objectives of this proposal are two-fold: 1) to provide high-quality mentoring to contribute to the career development of trainees from varying backgrounds and 2) to advance the quality…
Posted May 21, 2026
Modeling Core
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract – Modeling Core The Modeling Core, as part of SCRIPT, aimed to apply machine learning approaches to clinical and -omics data generated by the SCRIPT projects and cores to develop a models of severe pneumonia and ide…
Posted May 21, 2026
Project 003 - Lorena Amaral
US National Institute of General Medical Sciences · grant
Preeclampsia (PE) affects 5-7% of all pregnancies in the U.S and 30% of hypertensive disorders in pregnancy are caused by chronic hypertension (HTN) prior to pregnancy which increases the risk of superimposed PE (SIPE). Despite being a le…
Posted May 21, 2026
Project IV
US · IL NIH · grant
Project Summary Preeclampsia (PE) affects 5-7% of all pregnancies in the U.S. Despite being a leading cause of maternal death and perinatal morbidity, the most widely accepted treatment is early delivery of the baby. Healthy pregnancy is as…
Posted May 21, 2026
Brain and Behavioral Development in Autism Spectrum Disorder
US National Institute of Mental Health · grant
Adolescence is a complex time of heightened self-consciousness, risk taking and peer orientation which may be especially challenging for teens diagnosed with autism spectrum disorder (ASD). Longitudinal magnetic resonance imaging (MRI) stud…
Posted May 21, 2026
Genetic Strategies for Neurodevelopmental Research
US · IL NIH · NAICS 541714 · grant
Autism Spectrum Disorder (ASD) affects 1-2% of children in the United States. The etiology(ies) and neurobiological underpinnings of autism remains unclear and hence targets for effective medical treatments are rare. While myriad genetic mo…
Posted May 21, 2026
NIMH Space Activation, Maintenance, and Improvement
US National Institute of Mental Health · grant
In FY2025, the IRP made improvements to several research and office spaces. Importantly, we worked to install two Radiochemistry Hot Cells, and to create two tissue culture rooms in the Bldg 10 newly renovated E-Wing. Several projects were …
Posted May 21, 2026
Structure, Function and Pharmacology of Neurotransmitter Reuptake Systems
US · IL NIH · grant
Drugs which act on neurotransmitter transport systems are among the most widely used treatments for neuropsychiatric disorders, including major depression and attention-deficit disorders. These transporters are also a target for drugs of ab…
Posted May 21, 2026
Office of the Scientific Director
US · IL National Institute of Mental Health (NIMH) Intramural Research Program (IRP) / National Institutes of Health (NIH) · grant
Susan G. Amara, Ph.D., serves as the Scientific Director for the NIMH IRP and provides oversight to a wide-ranging mental health research portfolio. The Scientific Director provides centralized and supplemental resources, as appropriate, to…
Posted May 21, 2026
Transgenic Resources for Neuroscience Research
US · IL NIH (National Institute of Mental Health - NIMH) · grant
In FY25, the NIMH Transgenic Core was winding down its operations. Over the course of the fiscal year, the core worked on 30 cryopreservation projects and 35 rederivation projects. Cryopreservation (sperm/embryo) of mouse strains ensures p…
Posted May 21, 2026
Induction of strong and durable cellular and humoral immunity against HIV using DNA-LNPs
US · IL NIH · NAICS 541714 · grant
The overall goal of this proposal is to develop a vaccination strategy that induces strong and durable humoral and cellular immunity against HIV, providing long-term protection even with low neutralizing antibody (Ab) responses using DNA-LN…
Posted May 21, 2026
Targeting PD-1 Pathway for Functional Cure of AIDS
US National Institute of Allergy and Infectious Diseases · grant
This proposal aims to develop an effective therapy to achieve HIV remission by improving the magnitude, breadth, and function of anti-viral CD8 T cells and reducing viral reservoirs using the SIV/macaque model. Dysfunctional anti-HIV immuni…
Posted May 21, 2026
Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's disease
US · IL NIH · NAICS 541715 · grant
ABSTRACT Parkinson’s disease (PD) is a neurodegenerative disorder associated with Lewy Body pathology that can lead to progressive cognitive decline and Parkinson’s disease dementia (PDD), a form of Lewy Body Dementia. Cognitive dysfunction…
Posted May 21, 2026
Phonocath - An endovascular medical device to objectively evaluate Pulsatile Tinnitus
US National Institute on Deafness and Other Communication Disorders · grant
Project Summary This Phase I STTR project spearheaded by VDF Industries, in collaboration with UCSF, aims to radically improve the diagnosis of Pulsatile Tinnitus (PT). PT is a form of tinnitus characterized by the perception of a heartbeat…
Posted May 21, 2026
A Randomized Phase I Clinical Trial of HydroVax-CHIKV, a Novel Inactivated Chikungunya Virus Vaccine
US · IL NIH RePORTER · grant
Chikungunya virus (CHIKV) is an alphavirus that has gained significant attention due to its ability to cause large epidemics among susceptible populations and to be spread beyond endemic countries by international travelers. Among a populat…
Posted May 21, 2026