Live opportunities

21,760 contracts

🏛Federal 🗽State 🏞County 🏙City 🎓Schools 🚇Districts 📚Universities
Showing 25 / 21760 · page 42/871
Cytoskeletal force-sensing mechanisms
US National Institute of General Medical Sciences · grant
Cells perceive mechanical cues in their local environments, which must be converted into intracellular biochemical signals to modulate cellular physiology and control gene expression. This process of mechanical signal transduction (“mechano…
Posted May 21, 2026
Converting cytoskeletal forces into biochemical signals
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY Cells perceive mechanical cues in their local environments, which must be converted into intracellular biochemical signals to modulate cellular physiology and control gene expression. There is increasing appreciation for me…
Posted May 21, 2026
Project 3: Cellular and molecular mechanisms underlying effects from early life exposure to HAB toxins
US · IL NIH · grant
The overall objective of the proposed research is to elucidate the cellular and molecular mechanisms of toxicity from developmental exposure to harmful algal bloom (HAB) toxins. The HAB toxins domoic acid (DA), saxitoxin (STX), and anatox…
Posted May 21, 2026
Career Enhancement Program
US National Cancer Institute · grant
The evolution of prostate cancer research is highly dependent on the addition of new investigators with fresh, innovative concepts to advance the field. In recognition of the need to help establish independently funded investigators in the …
Posted May 21, 2026
Developing New Treatment Strategies for Neuroendocrine Prostate Cancer
US National Cancer Institute · grant
Project Summary/Abstract Neuroendocrine prostate cancer (NEPC) is the most virulent form of the disease. Loss of the tumor suppressors TP53/RB1 is ubiquitous in NEPC, but molecular mechanisms that explain how loss of TP53/RB1 promotes NEPC…
Posted May 21, 2026
Targeting Early Drivers of Prostate Cancer Lineage Plasticity
US National Cancer Institute · grant
Lineage plasticity (LP)—most commonly exemplified by loss of androgen receptor (AR) signaling and switch from a luminal to an alternate differentiation program—is now recognized as a critical determinant of lethality. Most efforts in the fi…
Posted May 21, 2026
HIV Enhanced Access Testing in Emergency Department program using a Systems Analysis and Improvement Approach (HEATED-SAIA) Cluster Randomized Trial
US · IL NIH RePORTER · grant
There are ~38 million people living with HIV (PLH) globally, with the majority in low-and middle-income countries (LMICs). Incident infections are concentrated in sub-Saharan Africa and focused in difficult to reach populations, who also ha…
Posted May 21, 2026
Left-Right Organizer Cellular and Molecular Dynamics Drive Early Cardiac Asymmetries
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Abnormal development of the left-right (LR) axis during embryogenesis can manifest as a broad spectrum of severe congenital heart diseases (CHDs), a group of conditions that affects 1% of all infants and in which th…
Posted May 21, 2026
Improving quantitative accuracy and tissue visualization in CBCT guided radiation therapy
US National Cancer Institute · grant
PROJECT SUMMARY Even though cone beam computed tomography (CBCT) is the most commonly used volumetric image guidance modality, its role has been severely limited in the context of treatment monitoring and patient-specific treatment modific…
Posted May 21, 2026
Elucidate the landscape of druggable targets for eliminating cancer persister cells
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Residual disease, caused by incomplete killing of cancer cell populations, is a critical limitation of targeted therapy, and almost inevitability leads to tumor recurrence. A growing body of evidence suggests a significant c…
Posted May 21, 2026
Age Related Hearing Loss and Vestibular Dysfunction
US · IL NIH · grant
Proposed studies are to test mechanism-based, clinically relevant interventions to meet the challenges of aging in the Veteran population. Hearing Loss is one of the most common service-related disabilities for those who served in the gulf …
Posted May 21, 2026
Novel mechanisms in the control of cAMP dynamics
US National Institute of General Medical Sciences · grant
GPCRs are the largest family of mammalian membrane receptors with an established relevance in therapy, representing a third of the currently FDA-approved drugs. Particularly GsPCRs via cAMP are involved in many physiological and pathophysio…
Posted May 21, 2026
Enhancing Solid Tumor lmmunotherapy with Targeted siRNA Delivery
US National Cancer Institute · grant
Abstract To address the significant challenges of immunotherapy for solid tumors, Absco Therapeutics (AbscoTx) has developed a novel intratumoral delivery system utilizing the Oncolymer™ platform. The need for new effective approaches to de…
Posted May 21, 2026
Lung Cancer Vaccine
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY Computerized chest tomography (CT) lung cancer screening programs have increased the detection of premalignant non-solid (NS) nodules that harbor preinvasive or minimally invasive adenocarcinoma. Given that NS nodules can…
Posted May 21, 2026
Defining virulence factor functions using minimal pathogen genomes
US · IL NIH · grant
Project Summary Pathogenic bacteria have developed an array of strategies to undermine the host's defense mechanisms. In the context of non-Typhoidal Salmonella Typhimurium, a notable strategy involves the confinement of a single bacterium …
Posted May 21, 2026
Oxysterol Regulation of Microbial Pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary The proposed project focuses on our recent discovery that immunological production of the oxysterol 25- Hydroxycholesterol (25HC) potently inhibits the cellular dissemination of two globally important bacterial pathogens, Li…
Posted May 21, 2026
Fluorination and Fluoroalkylation Strategies for Synthetic and Medicinal Chemistry
US · IL NIH · grant
SUMMARY Fluorination of an organic compound affects physicochemical properties, which in medicinal settings perturbs pharmacodynamic, pharmacokinetic, distribution, and/or metabolic profiles both in vitro and in vivo. Thus, the ability to …
Posted May 21, 2026
Computational methods for characterizing sources of variability in drug response
US · IL NIH · grant
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Drugs are approved by regulators because they are relatively safe and effective. However, there are typica…
Posted May 21, 2026
HIPC U19 Project 1
US · IL National Institute of Allergy and Infectious Diseases · grant
Posted May 21, 2026
NIH TETRAMER CORE FACILITY (HIV/AIDS)
US · IL National Institute of Allergy and Infectious Diseases (NIAID) · grant
The National Institute of Allergy and Infectious Diseases (NIAID) supports research on the basic understanding of immune responses leading to the development of vaccines and novel therapeutic agents for the prevention and treatment of infec…
Posted May 21, 2026
NIH Tetramer Core Facility for Immunologic and Infectious Disease
US National Institute of Allergy and Infectious Diseases · grant
The National Institute of Allergy and Infectious Diseases (NIAID) supports research on the basic understanding of immune responses leading to the development of vaccines and novel therapeutic agents for the prevention and treatment of infec…
Posted May 21, 2026
NIH Tetramer Core Facility (Influenza)
US · IL National Institute of Allergy and Infectious Diseases (NIAID) · grant
The National Institute of Allergy and Infectious Diseases (NIAID) supports research on the basic understanding of immune responses leading to the development of vaccines and novel therapeutic agents for the prevention and treatment of influ…
Posted May 21, 2026
NIH TETRAMER CORE FACILITY FOR INFECTIOUS DISEASES
US · IL National Institute of Allergy and Infectious Diseases (NIAID) · grant
The National Institute of Allergy and Infectious Diseases (NIAID) supports research on the basic understanding of immune responses leading to the development of vaccines and novel therapeutic agents for the prevention and treatment of infec…
Posted May 21, 2026
NIH Tetramer Core Facility
US National Institute of Allergy and Infectious Diseases · grant
The National Institute of Allergy and Infectious Diseases (NIAID) supports research on the basic understanding of immune responses leading to the development of vaccines and novel therapeutic agents for the prevention and treatment of infec…
Posted May 21, 2026
Development of a Novel Immunotherapeutic for Acute Myeloid Leukemia
US National Cancer Institute · grant
Acute Myeloid Leukemia (AML) and the Need for Advanced Treatment: AML is a prevalent hematological malignancy in adults, with a 5-year survival rate of only 32%. While approximately 32,000 AML patients are diagnosed annually in the US today…
Posted May 21, 2026