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Showing 25 / 21760 · page 15/871
Structural consequences of PKC-dependent phosphorylation of Kv7.2
US · IL NIH · grant
Project Summary M channels are critical for regulating the excitability of neurons. Dysfunction of M channel activity can cause epilepsy. While M channels have been intensely studied, the interplay of several G-protein-regulated signaling …
Posted May 21, 2026
Exploratory study of the efficacy and feasibility of the Aphasia: Nurturing Connections, Honoring Ongoing Relationships (ANCHOR) program
US · IL NIH · grant
Abstract Many people with aphasia (PwA) lose contact with the majority of their friends in the months following the onset of this disorder. Losing friendships and the ensuing social isolation place a large number of PwA at risk for reduced …
Posted May 21, 2026
Evaluation of Long Acting Injectable (LAI) and Teen clubs in adolescents (ATTUNE)
US · IL NIH · grant
PROJECT SUMMARY Significance: South Africa has the highest number of adolescents living with HIV in the world with increasing numbers expected to continue. However, adolescents living with HIV in South Africa have poor outcomes along each s…
Posted May 21, 2026
Randomized Trial of a Novel Approach to Addressing Fear of Progression in Advanced Cancer
US National Cancer Institute · grant
ABSTRACT Precision oncology has led to a growing population of adults with advanced cancer living increasingly longer lives in the face of profound uncertainty about the future, with over half reporting moderate to high fear of cancer progr…
Posted May 21, 2026
Factors of Resilience to Alzheimers Disease and Related Dementias among Latinx: The Role of Bilingualism
US National Institute on Aging · grant
Project Summary/Abstract As the population ages, Latinx communities, families, and healthcare systems will be confronted by the growing crisis of Alzheimer's disease and related dementias (ADRD). Identifying factors that confer resilience t…
Posted May 21, 2026
Mammary Epithelium Permeability, Lactation Outcomes, and Infant Health
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary/Abstract Human milk provides significant health benefits for infants. Beyond nutrients, breastmilk contains antibodies for immunity, growth factors associated with gut epithelial maturation, bacteria for establishment of the…
Posted May 21, 2026
Unraveling how Lipophilic Modulators Alter pLGIC Function via Interactions with the M4 Transmembrane Helix
US National Institute of General Medical Sciences · grant
Project Summary/Abstract Dr. Mark Arcario is a cardiothoracic anesthesiologist whose long-term goal is to be an independent physician- scientist studying molecular mechanisms of allostery in ion channels. His research background is in compu…
Posted May 21, 2026
The Virginia Advancing Cancer Control Engaged Research through Transformative Solutions Center
US National Institutes of Health (NIH) · grant
In the US, individuals and families living in poverty are placed at increased risk for cancer. Living in an under-resourced environment and having limited access to affordable and healthy food and opportunities for physical activity play a …
Posted May 21, 2026
PRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRY
US NIH · grant
PROJECT SUMMARY: This proposal is to continue our highly successful research track program (Columbia RTP) which aims to recruit and retain both MD/PhDs and other medical graduates with substantial research backgrounds into translational res…
Posted May 21, 2026
Humanization of a Notch 3 Agonist Antibody for Pre-Clinical Development of a CADASIL Treatment
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Notch 3 mutations are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a small vessel disease characterized by stroke and vascular cognitive impairment. Trans…
Posted May 21, 2026
Human Genetic risk factors for Disseminated Coccidioidomycosis (DCM)
US National Institute of Allergy and Infectious Diseases · grant
Scientific Project 3: Human Genetic Risk Factors for Disseminated Coccidioidomycosis (DCM) ABSTRACT This project will focus on elucidating human host genetic risk variants that predispose individuals to DCM. For the past 80 years, epidemiol…
Posted May 21, 2026
Training Grant in Genomic Analysis and Interpretation
US · CA · Los Angeles National Institutes of Health (NIH) · NAICS 611310 · grant
Project Summary/Abstract Modern genome projects have dramatically increased the amount of genetic and associated biomedical data available to researchers. Turning the flood of data generated by rapidly evolving genomic technologies and othe…
Posted May 21, 2026
Improving outcomes and reducing disparities through integrated primary care-specialty care implementation of the CDC Pediatric Mild TBI Guideline
US National Center for Injury Prevention and Control · grant
Mild traumatic brain injury (mTBI) is a common injury in childhood with the potential to have a substantial impact on function in the school and sports setting. Early recognition, followed by up-to-date mTBI care, has been demonstrated to i…
Posted May 21, 2026
UNITED: Understanding neurocognitive outcomes in Type 1 diabetes: Modifiable risk and protective factors in diverse youth
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Growing evidence suggests that individuals with Type 1 diabetes mellitus (T1D) are at risk for cognitive dysfunction over time, with approximately 28% of middle-aged adults with T1D and 48% of older adults with T1D meeting c…
Posted May 21, 2026
Optimizing feedback-based learning in children with developmentallanguage disorder.
US · IL NIH · grant
ABSTRACT This project aims to optimize a critical but understudied ingredient of language intervention provided to children with developmental language disorder (DLD) – feedback. The project is designed to bridge the gap between previous fi…
Posted May 21, 2026
Genes underlying reproductive behavior physiology and neuronal development
US · IL National Institutes of Health (NIH) / National Institute of General Medical Sciences (NIGMS) · grant
Project Summary/Abstract To understand mental health and disease, we need to understand the function of the brain at the level of genes, gene regulatory networks, neurons, circuit structure, and physiology. Drosophila has emerged as one of …
Posted May 21, 2026
Project 1: Therapeutic Gene Editing for Spinal Muscular Atrophy (Trailblazer)
US · IL NIH · grant
PROJECT SUMMARY PROJECT 1 (SMA) Spinal Muscular Atrophy (SMA) is a progressive motor neuron disease (MND) and the leading genetic cause of infant mortality across all ethnic groups. SMA is caused by the homozygous loss of the essential surv…
Posted May 21, 2026
Precision Base Editing for the Treatment of Motor Neuron Diseases
US National Institute of Neurological Disorders and Stroke · grant
Motor neuron diseases (MNDs) such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are a class of progressive neurodegeneration disorders, often caused by minor genetic abnormalities to which motor neurons are partic…
Posted May 21, 2026
Terahertz time-domain spectroscopic imaging of cornea for three dimensional mapping of hydration gradients
US National Eye Institute · grant
Project Summary There are several ophthalmological diseases and ailments that perturb the normal water content or hydration levels of the corneal layer. Among these, Fuchs’ dystrophy, keratoconus, and elevated intraocular pressure (IOP) - a…
Posted May 21, 2026
Developing a Community Health Training Program for Population Health Scholars
US · IL NIH · NAICS 611430 · grant
This project will: 1) Create an educational curriculum that examines the following components to optimize the health of women and their families; 2) Pilot test the educational curriculum to iterate and refine course content and supplementar…
Posted May 21, 2026
Optimizing the HIV Prevention and Care Continua in the United States
US National Institute of Allergy and Infectious Diseases · grant
Subgroups within the House and Ballroom Community (HBC) account for at least half of all new HIV infections in the United States (U.S.). At the same time there is a significant disparity in knowledge of, access to and uptake of pre-exposure…
Posted May 21, 2026
Advancing Gender and Health Justice Research and Education
US · IL NIH · grant
Multiple epidemics converge in the lived experiences of those at multiple intersecting minoritized social positions. People who identify as women experience gender-based violence, are vulnerable to HIV transmission, and face grave structura…
Posted May 21, 2026
Evolutionary Analysis and Comparative Genomics of Protein Superfamilies
US · IL National Institutes of Health (NIH) · NAICS 541714 · grant
The systematic analysis and discovery of biological conflict systems have been a major focus of research in the Aravind lab. Biological replicators, from genes within a genome to whole organisms, are locked in conflicts. Comparative genomic…
Posted May 21, 2026
Molecular mechanism of the piRNA biogenesis
US National Institute of General Medical Sciences · grant
Project title: Molecular mechanism of piRNA biogenesis Project summary Non-coding RNAs have diverse functions in eukaryotic cells. Use of these non-coding RNAs in therapeutic approaches is a promising but rather unexplored direction in bio…
Posted May 21, 2026
Cortical dystonia of prematurity
US · IL NIH · grant
PROJECT SUMMARY Preterm birth is the most common cause of cerebral palsy (CP) in the US and, consequently, the most common cause of childhood dystonia, a disabling condition affecting 2 of every 1000 Americans. Despite its high prevalence, …
Posted May 21, 2026