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Showing 25 / 21760 · page 25/871
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
US National Cancer Institute · grant
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers, according to SEER and CBTRUS. Malignant brain tumors cause…
Posted May 21, 2026
Bridges to the Baccalaureate Research Training Program at Howard University and Baltimore City Community College
US National Institute of General Medical Sciences · grant
The Bridges to Baccalaureate (B2B) Research Training Program at Howard University and Baltimore City Community College (BCCC) aims to create a novel, structured pathway for currently and formerly incarcerated individuals to pursue STEM care…
Posted May 21, 2026
The cellular molecular regulation of differing mechanisms of insulin resistance.
US · IL NIH · grant
Project Summary Molecular & Genetic Problem: Lipid-induced hepatic insulin resistance is due to diacylglyceride (DAG)-induced protein kinase C epsilon (PKCε) activation leading to inhibition of insulin receptor tyrosine kinase [4, 5]. Howe…
Posted May 21, 2026
Cell Identity and Signaling (CIS)
US National Cancer Institute · grant
Cell Identity and Signaling (CIS) Research Program Project Summary The key scientific goals of the Cell Identity and Signaling (CIS) Research Program are to advance discovery of novel molecular mechanisms of cell identity and cell signali…
Posted May 21, 2026
A sensitivity analysis framework for generalizing randomized clinical trial results in the presence of unmeasured treatment effect modifiers
US National Cancer Institute · grant
ABSTRACT Randomized controlled trials (RCTs) are the gold standard for assessing interventions for preventing and treating cancer, but their external validity is only guaranteed if the trial participants are a random sample from the target …
Posted May 21, 2026
The Michigan Department of Agriculture and Rural Development (MDARD) Animal Food Program (AFP) Animal Feed Regulatory ProgramStandards (AFRPS) Maintenance Track
US · MI Michigan Department of Agriculture and Rural Development (MDARD) Animal Feed Program (AFP) · grant
The Michigan Department of Agriculture and Rural Development (MDARD) Animal Feed Program (AFP) will enhance animal feed safety through the Animal Food Regulatory Program Standards (AFRPS) Maintenance Track. The AFRPS cooperative agreement w…
Posted May 21, 2026
Elucidating the causal associations underlying Alzheimer's disease
US National Institute on Aging · grant
Project Summary Alzheimer’s disease (AD) is a global crisis facing the aging population and society as a whole. With the number of people living with AD predicted to rise dramatically in the coming decades, it is imperative to pursue resear…
Posted May 21, 2026
B cell Response to Respiratory Viruses
US National Institute of Allergy and Infectious Diseases · grant
The B cell Immunobiology Section has evaluated the B cell response in multiple human Phase I clinical trials with experimental influenza vaccines conducted at the Vaccine Research Center with the goal of evaluating the magnitude and quality…
Posted May 21, 2026
Nicotinic Modulation of the Cognitive Control System in Late-Life Depression
US National Institute of Mental Health · grant
PROJECT SUMMARY: Deficits in cognitive control are core features of late-life depression, contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory. Clinically cha…
Posted May 21, 2026
Intermediate-sized Expanded Access Protocol for CNM-Au8 in Amyotrophic Lateral Sclerosis (ALS).
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Columbia University, Clene, and Synapticure are partnering and taking an innovative approach to provide persons living with amyotrophic lateral sclerosis ALS (pALS) across all 50 states— including those in remote/rural areas—access…
Posted May 21, 2026
Novel tools for measuring typhoid vaccine impact
US · IL NIH RePORTER · grant
Project Summary Typhoid fever is a leading cause of invasive bacterial illness and death worldwide, with the majority of infections occurring in low- and middle-income countries where water and sanitation infrastructure is poor. Highly anti…
Posted May 21, 2026
Strategies for tuberculosis control in prisons
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Tuberculosis remains one of the leading causes of death worldwide, despite the widespread availability of effective treatment and prevention measures. Prisons harbor among the highest rates of tuberculosis worldwide, and, in…
Posted May 21, 2026
Mentoring patient-oriented translational research in tuberculosis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Tuberculosis remains one of the leading causes of death worldwide, despite the widespread availability of effective treatment and prevention measures. To accelerate progress in reducing the global burden of tuberculosis, the…
Posted May 21, 2026
The MIGHT Trial - An Exploratory Clinical Trial of IVIG in anti-HMGCR ImmuneMediated Necrotizing Myopathy
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune mediated necrotizing myopathy (IMNM) is an increasingly recognized, severe subset of autoimmune myopathy that causes significant muscle weakness, morbidity, and o…
Posted May 21, 2026
Data Core
US · IL Columbia Alzheimer’s Disease Research Center (NIH RePORTER) · grant
Project Summary The Database Management and Statistical (DMS) Core of the Columbia Alzheimer’s Disease Research Center formalizes and expands central data management and biostatistical resources and functions that have existed since the …
Posted May 21, 2026
Path B NDA's Continued Implementation of FDA's Produce Safety Rule in Nebraska
US Food and Drug Administration · grant
NDA’s Continued Implementation of FDA’s Produce Safety Rule in Nebraska-Path B PAR-21-174 Summary/Abstract The Nebraska Department of Agriculture Produce Safety Program (NDA PSP) will be pursuing Path B for this grant application to build…
Posted May 21, 2026
Mapping dynamic functional networks across environments and backgrounds
US · IL NIH · NAICS 541714 · grant
Genome sequencing has provided an unprecedented view into the extent of human genetic variation. Yet, our ability to link specific genetic variants to phenotypes remains limited. Moreover, genetic interactions between complex combinations o…
Posted May 21, 2026
Allostatic load, stress Response to Social Stress, frequency of Stress Exposure, and social Network structure/function (ARSEN)
US National Institute on Minority Health and Health Disparities · grant
This project tests how various forms of social stress contribute to allostatic load and related health risk, and how aspects of social support networks may mitigate negative health effects of stress by reducing stress contagion. Our project…
Posted May 21, 2026
Innovative In-Situ Imaging Techniques for the Visualization of CNS associated HIV reservoirs in the Context of Substance Abuse
US · IL NIH · grant
Despite advances in our understanding of HIV pathogenesis, a knowledge gap remains concerning HIV viral reservoirs. Unknowns include, their various locations, size of the reservoir and the spatial/temporal kinetics for reservoir establishme…
Posted May 21, 2026
Synthetic fentanyls adversely affect the blood-brain barrier and HIV replication in the context of neuroHIV
US · IL NIH · NAICS 541714 · grant
In the past two to three decades, there has been a surge in the use, abuse, and misuse of opioids. Among opioid users, Illicit fentanyl use has become widespread in the US. Moreover, synthetic fentanyls rapidly flood the illicit drug market…
Posted May 21, 2026
29th-31st Scientific Conference Society on NeuroImmune Pharmacology
US National Institute on Drug Abuse · grant
The Society on Neuroimmune Pharmacology (SNIP) scientific meetings are focused on uncovering how substance abuse renders humans more susceptible to infection and chronic diseases, with a particular focus on human immunodeficiency virus-1 (H…
Posted May 21, 2026
GPCR signaling during embryonic organ formation
US · IL NIH · NAICS 541715 · grant
G-protein coupled receptors (GPCRs) are critical for almost every aspect of animal life. These proteins are embedded in the cell membrane and allow us to sense and respond to light, smells, and taste. GPCRs also control responses in both ou…
Posted May 21, 2026
Formation of the Drosophila salivary gland
US · IL NIH RePORTER · NAICS 541715 · grant
The FoxA family of winged-helix DNA-binding transcription factors (TFs) play major roles in the development of many organs in vertebrate embryos. In some cases, they are proposed to be determinants of specific cell fates because they are ex…
Posted May 21, 2026
Neuroinformatics Research Core
US · KS Kansas State University · grant
PROJECT SUMMARY: NEUROINFORMATICS CORE The Neuroinformatics (NI) Core was established at Kansas State University (K-State) with Phase 1 COBRE funding to support the primary projects, programs, and cores across CNAP. In Phase 2, the NI Core …
Posted May 21, 2026
The role of the RNA binding protein IMP1 in intercellular communication and necrotizing enterocolitis
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY Necrotizing enterocolitis (NEC) is a devastating inflammatory disease that affects the intestine of premature infants. There is major gap in our understanding of the pathophysiology of NEC, including no cure for this often d…
Posted May 21, 2026