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Showing 25 / 21760 · page 32/871
The Role of Annexin A1 Expression in Glioblastoma-Associated Astrocytes
US · MA · Boston NIH · NAICS 541714 · grant
Astrocytes profoundly influence immunity, but they are negligibly characterized in glioblastoma (GBM). My preliminary data suggest that GBM-associated astrocytes expressing annexin A1 (ANXA1) contribute to immunosuppression in GBM: 1) ANXA1…
Posted May 21, 2026
Skin cell heterogeneity in sensitivity to mustard-induced cell death
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Abstract Sulfur mustard, also known as mustard gas, is a threat in chemical warfare and terrorism. Although major advances have been made in understanding mustard-induced skin injury, effective countermeasures are lacking. Under an R34 gran…
Posted May 21, 2026
Interdisciplinary Training Program in Skin Biology
US · CA · Irvine NIH · grant
Abstract We propose a new interdisciplinary skin biology training program at the University of California, Irvine. The Program builds on a strong group of skin biology mentors affiliated with a NIAMS-funded Skin Biology and Disease Research…
Posted May 21, 2026
Skin Biology Resource-Based Center at UCI
US · IL National Institutes of Health (NIH) · grant
The broad, long-term objective of the UC Irvine Skin Biology and Disease Resource-based Center is to promote significant and innovative discoveries in regulatory mechanisms in skin biology and disease through cross-fertilization between mu…
Posted May 21, 2026
Circadian Clock Regulation in Skin
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT The circadian clock, an ancient, evolutionary conserved timing system required for optimal function of organs and organismal lifespan, is active in peripheral tissues, including the skin. Clocks in peripheral organs…
Posted May 21, 2026
Transcriptional Co-Regulators in Epidermis
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Although the epidermis is composed of morphologically distinct layers, single-cell RNA-seq experiments indicate that epidermal differentiation does not progress in discrete steps at a transcript level but is instead…
Posted May 21, 2026
Core D: Digital Pathology and CyTOF
US · MD Johns Hopkins University · grant
PROJECT SUMMARY The Digital Pathology and Mass Cytometry Core (Core D) will provide state-of-the-art technologies to enable high-parameter single-cell proteomic profiling for all the Research Projects in the proposed P01 Program Project Gra…
Posted May 21, 2026
Opportunities for Pathology Trainees in Cancer Research
US · MD NIH RePORTER · grant
Project Summary/Abstract Pathologists are uniquely positioned to contribute to cancer research. Their familiarity with disease classifications and pathogenesis, physical manifestations of tumors in tissue, and clinical challenges in cancer …
Posted May 21, 2026
Pathology Core
US National Institute on Alcohol Abuse and Alcoholism · grant
PROJECT SUMMARY The purpose of this shared resource is to provide human tissues, biological fluids, and expert pathologic interpretation for project investigators. The Pathology Core will work with an existing resource, the GI SPORE Tissue …
Posted May 21, 2026
Precision characterization of antimicrobial resistance gene dynamics in bloodstream infection risk after hematopoietic stem cell transplantation
US · NC NIH · grant
PROJECT SUMMARY Candidate: Tessa M. Andermann, MD, MPH is a fellowship-trained Infectious Diseases specialist who has been involved in patient-oriented research throughout her medical training. As an Assistant Professor of Medicine at UNC, …
Posted May 21, 2026
State-dependent modulation of retinothalamic axonal boutons
US National Eye Institute · grant
Summary Perception does not depend on environment alone, but also on brain state. Work from our lab and others show that visual responses to certain features are selectively gated depending on an animal's arousal state. What are the circuit…
Posted May 21, 2026
Roles of cortical neuromodulation and offline reactivation in memory consolidation of emotionally salient visual experiences
US National Institute of Mental Health · grant
Summary What are the mechanisms by which we selectively remember sensory cues associated with salient outcomes? Salient sensory experiences activate distributed patterns of neurons in regions including sensory cortex, amygdala, and hippocam…
Posted May 21, 2026
High-dimensional chemical targeting of multiple neuron types to regulate energy balance
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Summary Recent drugs for treating obesity and diabetes, while promising, have major side effects. For example, drugs that reduce food intake by targeting the melanocortin-4 receptor (MC4R) or the glucagon-like peptide-1 receptor (GLP1R) ind…
Posted May 21, 2026
Multiplexed Sensing and Control of Neuromodulators and Peptides in the Awake Brain
US National Eye Institute · grant
Summary Imbalanced levels of neuromodulators and other chemical signals contribute to a host of neurological disorders. Yet, previous studies describing these effects often examine only one molecule at a time, and typically provide a static…
Posted May 21, 2026
ASU Roybal Administrative Core
US National Institute on Aging · grant
Abstract (The Administrative Core) Living alone has become increasingly common over the past few decades among older adults, including those with cognitive decline (defined as subjective cognitive decline [SCD], mild cognitive decline [MCI]…
Posted May 21, 2026
Promoting a reparative instead of a degenerative outcome from loading of fatigue-damaged tendons
US · IL NIH RePORTER · grant
Tendinopathies are common injuries that typically result from accumulation of sub-rupture fatigue damage. We have developed an in vivo model of sub-rupture fatigue damage accumulation using the rat patellar tendon to investigate the onset a…
Posted May 21, 2026
Population and evolutionary dynamics of recombining genes and alleles in bacteria
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY/ABSTRACT Species are conventionally defined as groups of individuals that breed with each other and produce fertile offspring, but not with those of other species (according to Ernst Mayr's Biological Species Concept). Howe…
Posted May 21, 2026
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
US National Cancer Institute · grant
SUMMARY Alternative RNA splicing is a key step in gene expression regulation and contributes to transcriptional diversity by selecting which transcript isoforms are produced in a specific cell at a specific time point. Aberrantly spliced is…
Posted May 21, 2026
Building a spatial transcriptomics infrastructure for isoform profiling in aging pre-neoplastic tissues
US · IL National Cancer Institute (NCI) · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT Aging is the greatest risk factor for cancer, but it is not known which age-dependent cellular and molecular events drive cancer initiation. Spatial transcriptomic approaches are revolutionizing our understanding of…
Posted May 21, 2026
Vanderbilt Biomedical Informatics Training Program
US National Library of Medicine · grant
Vanderbilt University proposes a 5-year renewal of its Training Program in Biomedical Informatics and Data Science. Established in 2001, the Vanderbilt program offers MS and PhD degrees in biomedical informatics, nondegree postdoctoral trai…
Posted May 21, 2026
Reducing Off-Target Accumulation of Chemotherapeutic Nanomedicines
US · IL NIH · NAICS 541714 · grant
The work described in this proposal investigates a novel approach to reduce drug accumulation in healthy tissues and improve the efficacy of chemotherapy. More specifically, we take advantage of recent studies demonstrating an innate immune…
Posted May 21, 2026
Single-cell Analysis of Normal and Perturbed Dynamic and Spatial Biological Systems
US National Institute of Environmental Health Sciences · grant
The aim of this project is to utilize network models as a powerful framework to investigate the complexity, spatial organization and dynamics of biological processes during development from genetic, environmental and pharmacological perturb…
Posted May 21, 2026
Unraveling Drug Response Heterogeneity and Personalizing Treatment in Cancer
US National Institute of Environmental Health Sciences · grant
We developed PHENO-DEX, an experimental and machine-learning framework designed to characterize cancer cell response spectrums using dynamic molecular phenotypes. PHENO-DEX is specifically applied to dexamethasone (Dex) treatment, a widely …
Posted May 21, 2026
Benchmarking and Computational framework for Optimal Visualization and Interpretability of high-dimensional Spatiotemporal Data
US · IL NIH RePORTER · grant
Single-cell analysis have revolutionized biomedical research, enabling unprecedented insights into cellular heterogeneity, differentiation trajectories, and the mechanisms underlying complex diseases. Despite these advances, the interpretat…
Posted May 21, 2026
Cannabis, HIV and Mental Processing Systems (CHAMPS)
US · IL NIH · grant
ABSTRACT/PROJECT SUMMARY This proposal employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. We will acquire extensive phenotype data from peripheral and brain markers of i…
Posted May 21, 2026