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Showing 25 / 21760 · page 34/871
AI-Assisted Microendoscopy for the Early Detection of Esophageal Cancer
US · IL National Institutes of Health · grant
Abstract: Esophageal cancer is the 6th most common cause of cancer-related mortality worldwide. While esophageal squamous cell neoplasia (ESCN) carries a significant global burden, those in certain underserved geographic regions (South Amer…
Posted May 21, 2026
Interrogating unique DC adaptations to tissue to promote barrier immunity and tolerance
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project summary: The immune system faces the external world and encounters pathogens, including viruses in barrier tissues (e.g. skin, lung, and gut). There the immune system must detect and respond to pathogens, while simultaneously preven…
Posted May 21, 2026
New mechanisms governing skin tissue residency memory T cells
US · IL NIH · grant
PROJECT SUMMARY Given the recent SARS CoV2 pandemic, and monkeypox outbreak, there is an urgent unmet need to understand immunity in our barrier tissues (e.g. skin, lung, and gut) where viruses are encountered. Tissue specific memory is nee…
Posted May 21, 2026
Cole Eye Institute Vision Science Training Program
US National Eye Institute · grant
ABSTRACT This is a first renewal application for continued funding for the Cole Eye Institute Vision Science Training Program (CEIVSTP) which is specifically designed to train pre-doctoral Ph.D. students, medical students and post-doctoral …
Posted May 21, 2026
Mechanobiology of Bruch’s membrane during aging: Implications for age-related retinal degenerations.
US National Eye Institute · grant
PROJECT SUMMARY Aging is a significant risk factor for age-related macular degeneration AMD, a leading cause of blindness among the elderly. Aging and AMD induce progressive changes in Bruch’s membrane but to varying extents. There is incre…
Posted May 21, 2026
CORE A - Administrative Core
US National Eye Institute · grant
Administrative Core Project Summary The Administrative Core will oversee the efficient use of resources and the equitable utilization of the services provided by the Cole Eye Institute Vision Research Core supported by this P30 Core grant f…
Posted May 21, 2026
Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Adverse childhood experiences (ACEs), parenting, and social determinants of health (SDH) contribute to early life adversity (ELA), which can disrupt development in the brain, cardiovascular, metabolic, and immune systems to increase the ris…
Posted May 21, 2026
Virus breathing and assembly-disassembly transitions in host-entry
US · IL NIH · grant
Project Summary Viruses are serious human pathogens and viral infectious diseases represent a continuing challenge for global human health. The long-term focus of my research program is to uncover host-induced changes in pathogenic human vi…
Posted May 21, 2026
Understanding Mechanisms that Regulate Liver Growth and Function
US · IL NIH · grant
Project Abstract Chronic liver diseases are on the rise and are associated with almost $100 billion in healthcare costs in the United States. Since the liver is a primary site for detoxification and metabolizes a variety of chemicals, presc…
Posted May 21, 2026
Determining the nigrostriatal circuit basis of false auditory perceptions.
US National Institute of Mental Health · grant
Project Summary/Abstract Auditory perception can become disrupted in disorders like autism and psychosis. Higher-order auditory pro- cessing occurs in the auditory thalamus and cortex. In turn, these areas project to the tail of the striatu…
Posted May 21, 2026
Harnessing machine learning to develop new antibiotics for Neisseria gonorrhoeae
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT This proposal presents a five-year research and career development plan focused on machine learning (ML)-guided antibiotic development for multidrug-resistant Neisseria gonorrhoeae. The candidate, Melis Anahtar, MD…
Posted May 21, 2026
Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicine
US · IL NIH · grant
Project Summary Despite the progress made in precision oncology, clinicians typically face a vast volume and variety of next- generation sequencing and molecular data that is frequently intuitively processed to support high-stakes decisions…
Posted May 21, 2026
Identifying Global Rejuvenation Mechanisms in Tissues that Reverses Age-Related Phenotypes in Planarians
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT The preservation of organ functions, such as eyesight and mobility, is a significant health concern in the elderly population. Organ frailty and disease progression are associated with the dysregulation of tissue ho…
Posted May 21, 2026
Brainstem circuitry for sleep-wake control
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT It is now clear that poor sleep quality has dramatic health consequences, yet sleep medicine is still in great need for safe and efficient sleep aids. Recent major advances in understanding how the brain regulates …
Posted May 21, 2026
Impaired Sleep as a Target for Intervention Following Acute Organophosphate Intoxication
US · IL NIH · grant
Organophosphate cholinesterase inhibitors (OPs) were developed as agricultural insecticides and adapted to function as chemical weapons. OPs inhibit the acetylcholinesterase enzyme and acute intoxication can lead to a cholinergic crisis, st…
Posted May 21, 2026
INVESTIGATING THE ROLE OF HIPPOCAMPUS - ORBITOFRONTAL CIRCUITS FOR COGNITIVE FLEXIBILITY
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY Cognitive flexibility allows an individual to adapt established thinking patterns and behavioral responses to novel situations that may require new approaches than those that were previously learned in order to be solved cor…
Posted May 21, 2026
Transfusion-driven hyperhemolysis in sickle cell disease
US · IL NIH · grant
Red blood cell (RBC) transfusions remain a cornerstone treatment in the management of sickle cell disease (SCD). However, patients may experience delayed hemolytic transfusion reaction (DHTR) which in this patient population has an unpredic…
Posted May 21, 2026
Erythroblastic Island Macrophages in SCD Disordered Erythropoiesis.
US · IL NIH · grant
Erythroblastic island macrophages (EBI M) are niche cells for erythropoiesis. Alterations in EBI M contribute to the disordered erythropoiesis in various hematological diseases. We have documented that EBI M are characterized by the expr…
Posted May 21, 2026
Erythroblastic island macrophages in normal erythropoiesis and disordered erythropoiesis in polycythemia vera
US · IL NIH · grant
ABSTRACT Erythropoiesis occurs at the erythroblastic island where the central macrophage (EBI M) supports proliferation and maturation of the surrounding erythroid cells. Alterations in EBI M contribute to the disordered erythropoiesis in…
Posted May 21, 2026
Targeting T2 inflammation-evoked mechanical endotypes of ASM shortening in asthma
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY: Asthma is characterized by chronic inflammation and bronchial obstruction due to human airway smooth muscle (HASM) shortening. However, the underlying basis for an enhanced shortening or the hyper-contractile state of HASM …
Posted May 21, 2026
Microbial modulation of mucosal wound healing in the larynx
US · IL NIH · NAICS 541714 · grant
PROJECT ABSTRACT Voice disorders are among the most common communication disorders and estimated to affect 3-9% of Americans annually. These disorders are often associated with laryngeal inflammation secondary to epithelial injuries followi…
Posted May 21, 2026
Roles of Red Blood Cell Derived Extracellular Vesicles in Complement Activation and Thromboinflammation in sickle cell disease
US · IL NIH · grant
PROJECT SUMMARY Sickle cell disease (SCD) is caused by abnormal polymerization of deoxygenated sickle hemoglobin, which damages red blood cells (RBCs), resulting in hemolysis and thromboinflammation. Sickled-RBCs lead to heterogeneous clini…
Posted May 21, 2026
Health Communications (HC)
US · IL Rogel Cancer Center · grant
Patient-centered communication tailored to the specific needs of individuals, patients, and family members is an essential part of high-quality cancer care. The Health Communications Shared Resource (HC-SR) enables Rogel Cancer Center (Ro…
Posted May 21, 2026
Structures and Interactions of Chemokine Receptors
US National Institute of General Medical Sciences · grant
Abstract This is a revised competitive renewal application for a NIH R01 grant entitled “Structures and Interactions of Chemokine Receptors” that has been continuously funded and very successful for 22 years. The long- standing goals of thi…
Posted May 21, 2026
Improving Blood Pressure Screening and Treatment Strategies in Young Adults
US National Heart Lung and Blood Institute · grant
Project Summary The overall reduction in the rate of cardiovascular disease (CVD) over the past decades in the US has not extended to young adults aged 18-39 years. An increasing prevalence of CVD risk factors in young adults, including hig…
Posted May 21, 2026