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Showing 25 / 21760 · page 36/871
Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging
US · IL NIH · grant
SUMMARY To date nine hallmarks of the aging process have been described, which can be grouped into three major categories: primary hallmarks or cause of damage (genomic instability, telomere attrition, epigenetic alterations and loss of pro…
Posted May 21, 2026
Deconstructing aging with senolytic CAR T cells
US NIH Office of the Director · grant
SUMMARY Gaining a better understanding of aging biology is a pressing health and socioeconomic issue. In this regard, cellular senescence is a key, but poorly understood determinant of organismal aging. Senescence is a stress response progr…
Posted May 21, 2026
Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
US · IL NIH · NAICS 541720 · grant
PROJECT SUMMARY/ABSTRACT Overview: The goal of this project is to assess the efficacy of a tailored phone-delivered positive psychological intervention (PATH) for improving anxiety and depression symptoms, and quality of life (QOL) in hemat…
Posted May 21, 2026
Impact of preadolescent psychostimulants on neurophysiology and sleep/wake disturbances
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Children with attention-deficit/hyperactivity disorder (ADHD), whether taking stimulant medications or not, experience more sleep problems than their peers. These nighttime sleep problems often lead to daytime sleepiness, wh…
Posted May 21, 2026
Assessing the spatial and temporal scales of attention effects and attention-dependent cholinergic release in macque V4.
US National Eye Institute · grant
Explicitly or implicitly, there are currently three competing models for the role of the neuromodulator acetylcholine (ACh) in attention. The first asserts that the cholinergic system is spatially imprecise and contributes to a mechanism fo…
Posted May 21, 2026
The coordination of cell size control and cell cycle regulation at developmental extremes
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT A fundamental question in cell biology is how cells measure and maintain their characteristic sizes. We use two systems in Drosophila development to study cell size control that provide a natural system for uncoupli…
Posted May 21, 2026
DATA SCIENCE FOR CHILD HEALTH NOW IN GHANA (DS-CHANGE)
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
PROJECT ABSTRACT Our goal for the DS-CHANGE Training Program is to build data science capacity at Kwame Nkrumah University of Science and Technology (KNUST) and develop a cadre of qualified data scientists focused on child health in Ghana. …
Posted May 21, 2026
Metabolic Immunomodulation of Wound-Associated Macrophage Functional Plasticity as a Novel Diagnostic Target in Diabetic Veterans
US Veterans Affairs · grant
Within the Veterans Affairs healthcare system, around 25% of military veterans have diabetes and the economic burden of lower limb amputations exceeded $200 million for fiscal year 2010. Beyond the economic costs, the loss of mobility and i…
Posted May 21, 2026
SIP 24-003 Cancer Prevention and Control Research Network (CPCRN) Coordinating & Collaborating Centers at the University of North Carolina at Chapel Hill
US National Center for Chronic Disease Prev and Health Promo · grant
PROJECT SUMMARY/ABSTRACT For more than 20 years, the Cancer Prevention and Control Research Network (CPCRN) has been a national leader in developing and implementing effective interventions that decrease the burden of cancer in diverse and …
Posted May 21, 2026
Establishing a Collaborating Center for OACareTools PLUS (OACareTools Primary care-Led Usability & Scalability Study) and a Coordinating Center for an Arthritis Management & Wellbeing Research Network
US National Center for Chronic Disease Prev and Health Promo · grant
Abstract Arthritis, a highly prevalent, debilitating, and costly chronic disease, affects 53.2 million adults in the United States, with over 32 million having osteoarthritis (OA), the most common form. OA is managed mainly in primary care …
Posted May 21, 2026
DP24-004, PRC Core: Center for Health Promotion and Disease Prevention
US · IL National Institutes of Health (NIH) · NAICS 541715 · grant
ABSTRACT Diabetes affects over 37 million people in the US with the disease burden disproportionately borne by American Indian, African American, Hispanic/Latino, and rural subgroups (our priority populations). Despite progress in diabetes…
Posted May 21, 2026
Engaging school communities to prevent exemptions to kindergarten vaccination mandates
US · IL NIH · NAICS 541720 · grant
ABSTRACT Vaccine hesitancy, or the state of being conflicted about or opposed to getting vaccinated, is a “top 10” threat to public health, according to the World Health Organization. In the United States, vaccine hesitancy among parents ha…
Posted May 21, 2026
Transforming motivational interviewing into a computable model for automated patient diabetic counseling.
US · IL NIH · NAICS 541715 · grant
Project Abstract The incidence of type 2 diabetes mellitus (T2DM) is staggeringly high in the United States, and it is expected to exponentially increase in the next few decades. Regulating health behavior that leads to T2DM is a key factor…
Posted May 21, 2026
Harnessing the nervous system to overcome resistance to immunotherapy in oral cancer
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT To maximize their growth and metastatic potential, solid tumors promote the formation of new nerve fibers in the tumor microenvironment (TME). In patients with oral, prostate, breast, gastric, pancreatic, and other …
Posted May 21, 2026
Defining the Role of Tumor-Neutral Crosstalk in head and Neck Cancer Progression and Treatment Resistance
US · IL NIH · grant
PROJECT SUMMARY Solid tumors can shape their microenvironments to maximize their growth and metastatic potential. The formation of new nerve fibers within and around tumors can alter tumor behavior, and higher densities of nerve fibers in t…
Posted May 21, 2026
Cancer Neuroscience: Crossing Disciplines to Revolutionize Cancer Treatment
US National Cancer Institute · grant
Accelerated understanding of nervous system functions and cancer has led to cancer neuroscience evolving into a new frontier of discovery in cancer biology and therapy. The 3rd Cancer Neuroscience: Crossing Disciplines to Revolutionize Canc…
Posted May 21, 2026
The Role of Prenatal Cannabis Exposure in Reward-related Neural Circuitry and Psychotic-like Experiences in Youth
US National Institute on Drug Abuse · grant
PROJECT SUMMARY Cannabis use is becoming increasingly common in the US, and past-month use among pregnant women increased by almost 60% from 2003 to 2019. Despite increasingly permissive legislation, our knowledge of the behavioral and neu…
Posted May 21, 2026
Component for Institution # 269291
US · IL NIH · grant
SUMMARY The current HIV-1 pandemic is one where people living with HIV (PWH) have had well-suppressed infection with therapy for prolonged periods of time. This has guided research towards focusing on (i) comorbidities (aging, cardiovascula…
Posted May 21, 2026
Investigating the role of cGAS signaling and microglial senscence in tauopathy
US National Institute on Aging · grant
PROJECT SUMMARY Innate immune antiviral pathways are upregulated in Alzheimer’s disease (AD) and are thought to drive AD pathogenesis. The specific mediators of maladaptive antiviral responses in AD are still not understood. Innate immune s…
Posted May 21, 2026
Randomized Control Trial of oxygen therapy in Children and Adolescents with Down Syndrome and Obstructive Sleep Apnea
US National Heart Lung and Blood Institute · grant
ABSTRACT: A large percentage of children with Down Syndrome (DS) have obstructive sleep apnea (OSA) that is suboptimally treated by first-line surgical interventions. The persistence of OSA-related nightly intermittent hypoxemia and fragmen…
Posted May 21, 2026
Evaluation of a specific LXR/PPAR agonist for treatment of Alzheimer's disease
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Alzheimer's disease (AD) is the sixth leading cause of death in United States, yet this indication lacks truly effective therapeutics to mitigate this disease. To develop novel and effective therapies, a novel (partial) L…
Posted May 21, 2026
Biospecimen Repository Core
US · IL National Institute of Neurological Disorders and Stroke (NINDS) · grant
The NINDS Biospecimen Core Facility was established in February 2023 in a newly renovated laboratory space, Room 2N104, located in Building 10. As of September 2024, the repository is actively storing, maintaining, and distributing samples…
Posted May 21, 2026
Project 1: Biomimetic Interactions Between Bacterial Pathogens and the Gastrointestinal Epithelium
US · IL NIH · grant
PROJECT SUMMARY (Project 1) Helicobacter pylori and Salmonella enterica serovar Typhi (Typhi) are both strictly human-adapted pathogens that colonize the stomach and intestine and are major public health threats worldwide that disproportion…
Posted May 21, 2026
Core B: Translational, Cellular and Molecular Analysis
US National Cancer Institute · grant
ABSTRACT – CELLULAR IMAGING AND GENOMICS CORE B Core B, the Cellular Genomics and Imaging Core (CGI), will provide centralized experimental processing services and primary data analysis for the Program Project Grant (PPG). The interactions …
Posted May 21, 2026
A self-administered PrEP Decisional Aid for dissemination with HIV self-test kits (DASH)
US National Institute of Mental Health · grant
Project Summary Our mixed-methods implementation hybrid (type I) pilot RCT will develop a self-administered PrEP Decisional Aid for dissemination with Self-administered HIV test kits (DASH), and pilot it with 120 users of the Together Take …
Posted May 21, 2026