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Showing 25 / 21760 · page 44/871
A Rigid Body Database On Human Movement
US · IL NIH · grant
The primary objective of this study remains the same: to link the neuro-muscular system and movement biomechanics of people with and without physical impairments to his or her ability to perform activities of daily living, including gait. M…
Posted May 21, 2026
Integrating brain and behavioral measures of central pain inhibition to personalize treatment in chronic pain management
US National Institute of Neurological Disorders and Stroke · grant
Although pain inhibition by the central nervous system (CNS) strongly modulates acute pain in the lab, its relevance for patient outcomes is less well known. Studies with animal models, human behavioral paradigms, and neuroimaging have impl…
Posted May 21, 2026
Leveraging inter-individual differences in walking pain and impairment to elucidate whole-person mechanisms of knee osteoarthritis
US · IL NIH · grant
Project Summary/Abstract Knee osteoarthritis (OA) is a common and debilitating condition, affecting millions in the United States of America. From 1990 to 2020, OA ranked as the 14th highest cause of age-adjusted years lived with disability…
Posted May 21, 2026
Decoding viral transmission, tropism and inflammation: from single cell to organism
US National Heart Lung and Blood Institute · grant
Inflammation is activation of the immune system. It plays an important role for fighting infectious pathogens but unregulated contributes to the development of many childhood and adult chronic diseases including cardiovascular disease, art…
Posted May 21, 2026
Immunophenotyping by high-dimensional cytometry and machine learning
US · IL NIH · grant
We recently transitioned to spectral flow cytometry (instead of mass cytometry): this is faster, cheaper, more reliable, high-througput experimental techniques with no downside in terms of the measurement quality. We have also introduced a …
Posted May 21, 2026
Dynamics of hematopoietic differentiation
US National Cancer Institute · grant
We finalized a manuscript detailing our most recent experimental results and modeling effort. This paper was submitted to biorxiv and is being adjusted to address reviewers' comments. Homeostatic hematopoiesis is a dynamical process, charac…
Posted May 21, 2026
Dynamics of viral infection
US · IL NIH · NAICS 541714 · grant
Our recent projects pivoted from immune responses to coronaviruses to the more fundamental aspects of host/pathogen interactions namely the tug-of-war between viral replication and innate immune response at the individual cell level. Cytoso…
Posted May 21, 2026
Phenotypic variability within isogenic population of lymphocytes
US National Cancer Institute · grant
We expanded the project horizon by collaborating with Naomi Taylor (CCR) and Paul François (UMontréal) in order to usher new Chimetic Antigen Receptor (CAR) T cells. CAR T cell therapy has been transformative for blood cancers but remains l…
Posted May 21, 2026
Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease
US · IL NIH · grant
Cardiovascular disease is a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Characterized by progressive renal dysfunction, ADPKD imposes very significant healthcare and economic…
Posted May 21, 2026
Fostering Underrepresented Employees' Resilience and Zeal for Academia (FUERZA)
US · IL NIH (National Institute on Deafness and Other Communication Disorders - NIDCD) · grant
Project Summary/Abstract The broad, long-term objectives of the Fostering Underrepresented Employees’ Resilience and Zeal for Aca- demia (FUERZA) project are three-fold. The first is to enhance diversity in NIDCD’s extramural workforce by c…
Posted May 21, 2026
Mechanisms That Control Antigen Receptor Variable Region Exon Assembly
US · IL NIH · grant
7. Project Summary/Abstract. During the past funding period, we discovered that the cohesin-mediated loop extrusion process involved in genome-wide modulation of chromosome architecture plays fundamental roles in V(D)J recombination and th…
Posted May 21, 2026
Mechanisms that Regulate Antibody Class Switch Recombination and Somatic Hypermutation
US · IL NIH · grant
Project Summary/Abstract of Research Plans for the Extension Period The first two specific aims of this R37 grant were to test our hypothesis that cohesin-mediated loop extrusion plays a key role in lgH class switch recombination (CSR) and …
Posted May 21, 2026
Coordinated responses to host-derived stresses in C. neoformans
US National Institute of Allergy and Infectious Diseases · grant
SUMMARY Although potent antifungal agents are currently available, invasive fungal infections remain highly prevalent causes of disease and death, especially in our most vulnerable patients with defective immune systems. AIDS, organ transp…
Posted May 21, 2026
Copper homeostasis in fungal pathogenesis
US · IL NIH · grant
SUMMARY Copper (Cu) is an essential trace element and a catalytic cofactor for a variety of enzymes involved in cell growth, development, and stress resistance. Fungal systems have been instrumental in identifying mechanisms of Cu utilizat…
Posted May 21, 2026
Advancing KNX100 for the treatment of opioid withdrawal: preclinical efficacy and toxicology, and a phase 1 clinical program.
US National Institute on Drug Abuse · grant
Application Identifier: 364510 Application Project Title: Advancing KNX100 for the treatment of opioid withdrawal: preclinical efficacy and toxicology, and a phase 1 clinical program. Project Summary/Abstract Kinoxis Therapeutics Pty Ltd is…
Posted May 21, 2026
EAT: A Reliable Eating Assessment Technology for Free-living Individuals.
US · IL National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary/Abstract Overeating and unhealthy eating are often associated with various health risk conditions such as obesity, high blood pressure, and some chronic diseases. To get a better understanding of overeating and unhealthy eat…
Posted May 21, 2026
PASSPORT: PASsive Sensing to Prevent stress-related Overeating in Real-Time
US National Heart Lung and Blood Institute · grant
Project Summary/Abstract Stressful events, overeating, and obesity have been associated with cardiovascular disease (CVD). Characterizing the relationship between these factors may inform targeted and timely interventions to prevent overeat…
Posted May 21, 2026
SESAME: Sun Exposure and Activities after Skin CAncer: Optimization of Mhealth IntErventions
US National Cancer Institute · grant
ABSTRACT There are currently 1.36 million melanoma survivors in the US, and this number is expected to increase to 1.92 million by 2030. Most melanoma patients (92%) survive 5 or more years but face an increased risk of new primary melanoma…
Posted May 21, 2026
Elucidating the role of FBLL1 in ribosome function during neuronal differentiation
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY Chemical modifications of RNA have been seen to have numerous biological consequences including regulation of development. Ribosomal RNA is heavily modified by 2’O methylation (2’O-Me). There is increasing evidence that regu…
Posted May 21, 2026
ECHO-PROTECT Cohort Study Site in Puerto Rico
US · IL National Institutes of Health · grant
The effect of early environmental exposures on child health and development is an important area of public health that no single cohort, or even a few, can answer alone. Determining this effect becomes more challenging when considering that…
Posted May 21, 2026
Biomechanics of the Human Brain During High-Severity Impacts: A Multimodal Approach
US · IL NIH · grant
Project Summary Traumatic brain injury (TBI) is a significant health care problem, affecting over 2.5 million people in the United States annually. Most cases are classified as mild or concussive TBI, caused by a rapid acceleration to the s…
Posted May 21, 2026
Cannabis use and cardiovascular health outcomes among patients with high blood pressure
US · IL National Institutes of Health · grant
ABSTRACT In recent years, cannabis, and its constituents (delta-9 tetrahydrocannabinol [THC] and cannabidiol [CBD]) have been promoted as natural remedies, with chronic disease patients as prominent marketing targets. Consequently, adults w…
Posted May 21, 2026
Multi-tissue type condensations for trachea tissue regeneration via individual cell bioprinting
US Veterans Affairs · grant
Abstract As a result of prolonged intubation, tracheostomy, external trauma, penetrating fragment projectiles, gunshot wounds and improvised explosive devices during combat, and benign or malignant tumors, many soldiers and veterans in the …
Posted May 21, 2026
In situ bioprinting of high-density cell-laden core-shell microgel bioinks enabling cellular condensation for vascularized bone tissue regeneration
US · IL NIH RePORTER · grant
Abstract Bone damage and loss resulting from combat associated penetrating fragment projectiles, gunshot wounds and improvised explosive devices are some of the most common injuries US Military personnel experience and contribute to increas…
Posted May 21, 2026
Individual cell bioprinting to generate multi-tissue type condensations for osteochondral tissue regeneration
US · IL NIH · grant
Abstract Osteochondral defects of the knee are common worldwide, yet there are few viable options for patients with damaged osteochondral tissue as current treatments do not consistently regenerate functional tissue. The standard of care fo…
Posted May 21, 2026