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Showing 25 / 21760 · page 47/871
Different consequences of cellular aging in cortical versus cancellous bone- Resubmission
US · IL NIH · grant
Project Summary/Abstract Aging is responsible for the majority of fractures in both women and men. The cellular changes in the skeleton of aged mice are similar to those observed in aged humans. In mice, trabecular bone loss is associated w…
Posted May 21, 2026
Antagonism of RANKL signaling by estrogen in osteoclasts
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Loss of estrogens at menopause is a major cause of osteoporosis due to an increase in number and activity of the cells that resorb bone called osteoclasts. Estrogens inhibit bone resorption in part via direct effect…
Posted May 21, 2026
UIC Center for Healthy Work
US · IL UIC Center for Healthy Work · grant
ABSTRACT The UIC Center for Healthy Work’s (CHW) aims to identify and promote employment programs, practices, and policies that will improve worker and community health. Our vision is a future of work that promotes inclusive and equitable o…
Posted May 21, 2026
Predictive modeling of CD-68 inflammatory and anti-inflammatory chromatin packing domains for personalized biomarker discovery
US · IL National Institutes of Health · grant
Project Summary/Abstract Ulcerative colitis (UC) is a complex disorder impacting millions of people worldwide resulting in significant costs, chronic debilitating symptoms, and complications such as colon cancer. Even with biologic therapie…
Posted May 21, 2026
Administrative Core
US National Institute of Dental and Craniofacial Research · grant
The Administrative Core of CREATE serves as the foundation for the Center’s operations, providing comprehensive oversight, strategic coordination, and seamless integration of activities across all cores and member institutions. It ensures e…
Posted May 21, 2026
TMJ Disc Regeneration
US National Institute of Dental and Craniofacial Research · grant
Patients opting for TMJ disc removal face issues due to the absence of FDA-approved replacements, leading to bone-to-bone contact and subsequent joint problems. Autografts, like dermis-fat grafts, typically resorb within a year. Our goal is…
Posted May 21, 2026
Clinical Impact and Feasibility of Virtual Reality (VR) for Irritable Bowel Syndrome: A Pilot Randomized Controlled Trial Comparing VR Cognitive Behavioral Therapy vs. Sham VR
US · IL NIH · grant
PROJECT SUMMARY This proposal aims to conduct a pilot randomized controlled trial (RCT) to test the clinical impact and feasibility of a virtual reality (VR) cognitive behavioral therapy (CBT) program vs. sham VR among patients with irritab…
Posted May 21, 2026
The role of macrophage subpopulations in the rejuvenation of fracture repair
US National Institute on Aging · grant
The pace of bone repair slows with aging, increasing the chance of developing a delayed union or non-union. These complications are treated with surgical procedures causing significant morbidity and even mortality, especially in older adult…
Posted May 21, 2026
Molecular Etiology of Enchondromatosis
US · IL NIH · NAICS 541714 · grant
Abstract More than 3% of the population develops an enchondroma (ECA), a benign tumor in bone composed of cells derived from the growth plate that can cause pain, deformity, and can be responsible for pathologic fractures. Enchondromas can …
Posted May 21, 2026
Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma
US National Cancer Institute · grant
Undifferentiated pleomorphic sarcoma (UPS) is a soft tissue sarcoma, with one of the worst prognosis. We will build on our discovery that UPS contains a small subpopulation of metastasis initiating cells (MCs) that are enhanced for their ab…
Posted May 21, 2026
Stem Cell Dysfunction in Aged Skeletal Muscle
US · IL NIH · grant
Abstract One of the greatest mysteries in ageing biology is to understand why many tissues and organs in our body, including skeletal muscle, decline in function as we get older? Recent studies suggest that the inability of muscle stem cell…
Posted May 21, 2026
Investigating the link between pericyte dysfunction and loss of glucose homeostasis in COVID-19
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
ABSTRACT The coronavirus disease 2019 (COVID-19) is a global healthcare crisis that in the USA kills about 1 person every minute. It is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). While respiratory failure is…
Posted May 21, 2026
Targeted Awareness and Education on Options in Uterine Fibroids
US · IL NIH · NAICS 541720, 611710 · grant
PROJECT SUMMARY – PROJECT 1 Non-Hispanic Black, African American (BAA) women have a 2 to 3 times higher uterine fibroid incidence rate compared to non-Hispanic White women. BAA women report experiencing higher disease burdens compared to no…
Posted May 21, 2026
A novel pediatric prosthetic foot for functional multi-axial mobility during active play
US · IL National Institutes of Health (NIH) · NAICS 339113 · small business · grant
Project Summary The goal of this Small Business Innovation Research (SBIR) development project is to establish technical merit, feasibility, and potential to commercialize a mechanical prosthetic foot- ankle with normalized ankle range of …
Posted May 21, 2026
Neural basis of precedence-type sound localization processes
US · IL NIH · grant
Project Summary This research project aims to study the neural basis of the precedence-type sound localization processes, including the Franssen effect. This central computation is key to understanding the normal function of auditory percep…
Posted May 21, 2026
Targeted degradation of CDK4 and 6 to overcome treatment resistance in breast cancer
US · IL National Institutes of Health (NIH) · grant
Abstract Although CDK4/6 inhibitors (in combination with an endocrine therapy) are the preferred systemic therapy for treatment of patients with metastatic, Estrogen Receptor-positive (ER+) breast cancer (BC), development of resistance to C…
Posted May 21, 2026
Addressing Food Access and Physcial Activity to Improve Diabetes Prevention Outcomes Among Underserved African Americans
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Diabetes is one of the most pressing public health challenges in the U.S., with over 98 million adults – more than one in three – already living with pre-diabetes mellitus (pre-DM), placing them at heightened risk f…
Posted May 21, 2026
Decoding ensemble dynamics from cortico-amygdalar circuits during social choice
US National Institute of Mental Health · grant
Project Summary Social relationships are a key component of human health and survival and impairments in social behavior have a major impact in many psychiatric conditions. Yet despite the importance of social context to health, there remai…
Posted May 21, 2026
CTSA K12 Program at Wake Forest
US National Center for Advancing Translational Sciences · grant
The Wake Forest (WF) Clinical and Translational Science Institute (CTSI) joined the CTSA consortium in 2015 with the goal of catalyzing our health system’s transformation into an exemplary Learning Health System (LHS). Since then, we have e…
Posted May 21, 2026
Pilot & Feasibility Program
US · NC NORTH CAROLINA DIABETES RESEARCH CENTER (NCDRC) · $25k-100k · grant
NORTH CAROLINA DIABETES RESEARCH CENTER (NCDRC): PILOT AND FEASIBILITY CORE SUMMARY To provide research support to explore feasibility of concepts related to the NCDRC’s goals and provide a mechanism to generate sufficient preliminary data …
Posted May 21, 2026
Integrated Reward-Inflammation Model of First Onset of Major Depression in Adolescence
US National Institute of Mental Health · grant
7. Project Summary/Abstract Adolescence is an “age of risk” for the emergence of 1st onset of major depressive disorder (MD). Despite its prevalence and public health significance, major unanswered questions exist regarding the mechanisms i…
Posted May 21, 2026
Integrated Reward-Circadian Rhythm Model of First Onset of Bipolar Spectrum Disorders in Adolescence
US · IL NIH · grant
7. Project Summary/Abstract Adolescence is an “age of risk” for the emergence of first onset of bipolar spectrum disorders (BSD). Despite their prevalence and public health significance, major unanswered questions exist regarding the mechan…
Posted May 21, 2026
Data Management and Statistics Core
US National Institute on Aging · grant
Data Management and Statistics Core Summary The Data Management and Statistics Core (DMSC) will foster the Yale ADRC through rigorous collaborative engagement with investigators, the training of scientists, and the development of novel stat…
Posted May 21, 2026
Design Statistics Core (D)
US · IL National Institute on Aging (NIA), NIH · grant
The design and analysis of embedded pragmatic clinical trials (ePCTs), particularly those evaluating the effectiveness of interventions to improve dementia care, pose unique challenges requiring specialized expertise. As such, the Design an…
Posted May 21, 2026
Antigen presentation during Trypanosoma cruzi infection: in search of a new effective vaccine
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT Chagas disease, caused by the parasite Trypanosoma cruzi, is a significant global health concern, primarily affecting Latin America but also impacting regions in Europe and the US. Currently, there are limited treat…
Posted May 21, 2026