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Showing 25 / 21760 · page 49/871
Research Project 3
US National Institute on Drug Abuse · grant
PROJECT SUMMARY American Indians (AIs) have the highest rate of prescription opioid misuse of any sociodemographic group in the United States (US). Increasing rates of opioid misuse have led to increased prevalence of injection drug use (I…
Posted May 21, 2026
Adapting a Network-Oriented HIV Prevention Intervention for Rural People Who Inject Drugs (PWID)
US National Institute on Drug Abuse · grant
Project Summary Recent HIV outbreaks among rural people who inject drugs (PWID) highlighted significant gaps in HIV prevention science. HIV risk behaviors among PWID are influenced by several factors, including access to sterile injection e…
Posted May 21, 2026
Examining the Role of a Pathogenic HTT Isoform, HTT1a, in Somatic Expansion and RNA Aggregation in Huntington's Disease
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Huntington’s Disease (HD) is caused by expanded CAG repeats in exon 1 of the Huntingtin (HTT) gene, resulting in transcription of mutant HTT mRNA and translation of mutant protein, both of which form nuclear aggregates in ne…
Posted May 21, 2026
A multispecies system for elucidating proliferative control mechanisms during mammalian skin and musculoskeletal regeneration
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Abstract While antifibrotic therapies continue to advance, they fall short when treating large or chronic wounds. Essential to developing new regenerative strategies is a comprehensive understanding of how cell proliferation is activated, …
Posted May 21, 2026
MARC at the University of Colorado Denver
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY The diversity of the United States population is not reflected in its biomedical sciences workforce, with the greatest disparities at the highest levels of degree attainment and in careers that require advanced degrees. Inst…
Posted May 21, 2026
Investigating the in vivo regulation of Dynein activity
US National Institute of General Medical Sciences · grant
The establishment and maintenance of polarity is a fundamental feature of eukaryotic cells. Molecular motors within cells transport a variety of cargo including RNAs, proteins, vesicles, and organelles. The asymmetric distribution of these …
Posted May 21, 2026
Biomarker validation for intraductal papillary mucinous neoplasms of the pancreas
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT: Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are cystic tumors that represent a radiographically identifiable precursor lesion of pancreatic cancer. Currently, IPMN represent our best opportunity…
Posted May 21, 2026
Orientia tsutsugamsuhi promotes interplay between circadian rhythm and hypoxic responses
US National Institute of Allergy and Infectious Diseases · grant
SUMMARY Converting the host cell into a supportive niche is essential for intracellular pathogen survival and replication. Orientia tsutsugamushi is a genetically intractable obligate intracellular bacterium that causes scrub typhus, a glob…
Posted May 21, 2026
Multifunctional roles of an Orientia tsutsugamushi nucleomodulin
US National Institute of Allergy and Infectious Diseases · grant
SUMMARY Orientia tsutsugamushi is a genetically intractable obligate intracellular bacterium that causes scrub typhus, a globally emerging infection with a high fatality rate. Disease progression depends on bacterial-driven modulation of ho…
Posted May 21, 2026
MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - FIELD CENTER
US National Heart Lung and Blood Institute · grant
The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of c…
Posted May 21, 2026
Cardiovascular Health Trajectories from Birth Thru Adolescence in A Diverse Cohort of Children
US National Heart Lung and Blood Institute · grant
Abstract The overarching goal of this proposal is to identify CVH trajectories from birth through age 20 among a diverse cohort of 7,000 children and their families who already have clinical phenotyping to which we will add detailed behavio…
Posted May 21, 2026
Determining the role of astrocyte BMP signaling in cortical astrocyte heterogeneity
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Astrocytes, like neurons, display regional and intra-regional heterogeneity in both function and transcriptional state. This heterogeneity impacts neighboring neurons, making it imperative to identify on a molecular level wh…
Posted May 21, 2026
Targeted Degradation of Extracellular Proteins to Enhance Brain Plasticity
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY The young brain displays remarkable plasticity. This includes an ability to remodel neuronal synaptic connections to learn new tasks in health, as well as being able to repair connections and restore function after injury. I…
Posted May 21, 2026
Development and testing of a digitally assisted risk reduction platform for youth at high risk for suicide
US National Institute of Mental Health · grant
ABSTRACT Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Although promising approaches are available for preventative interventions with youth at-risk for suicide, …
Posted May 21, 2026
Building a Contextually Triggered Just-in-Time Intervention for Opioid UseDisorder: Stakeholder Evaluation and User Centered Design
US National Institute on Drug Abuse · grant
Abstract The opioid epidemic represents a major public health crisis in the U.S. Although medications such as buprenorphine are the current gold standard treatment for individuals diagnosed with opioid use disorder (OUD), a significant prop…
Posted May 21, 2026
BRITE 2.0: A just-in-time adaptive intervention for suicide safety planning in adolescents
US National Institute of Mental Health · grant
ABSTRACT Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. While suicide safety planning interventions can be effective in reducing suicidal behavior, adolescents oft…
Posted May 21, 2026
Role of stromal inflammatory signaling in the aging of lung resident lymphocytes
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Immune system dysfunction has been implicated in the pathogenesis of several age-related lung diseases. Interestingly, multiple recent studies have identified the tissue microenvironment as playing a critical role in the pat…
Posted May 21, 2026
Share plus: Continuous Glucose Monitoring with Data Sharing in Older Adults with T1D and Their Care Partners
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Older adults with type 1 diabetes (T1D) have an increased risk of hypoglycemia and hyperglycemia that can result in grave health consequences, such as seizures, falls, and myocardial infarctions. Care partners (e.g., spouses, friends) regul…
Posted May 21, 2026
Minnesota Advancing Science and Cancer EducatioN Discoveries (MASCEND)
US National Cancer Institute · grant
This renewal of our M-ASCEND Program to the NCI Youth Enjoy Science (YES) mechanism leverages 17 years of cancer research-focused mentored education activities at the University of Minnesota (UMN) Masonic Cancer Center and PHDR Program in t…
Posted May 21, 2026
Cancer Related Health Disparities Training Program
US National Cancer Institute · grant
PROJECT ABSTRACT/SUMMARY This is a proposal for the competing continuation of the University of Minnesota T32 Cancer Health Disparities Training Program, funded by NCI since 2011. Disparities in cancer incidence, prevalence, screening, trea…
Posted May 21, 2026
Center for Chronic Disease Reduction and Equity Promotion Across Minnesota (C2DREAM)
US National Institute on Minority Health and Health Disparities · grant
Posted May 21, 2026
Clinical and Translational Science Workforce Development through a Statewide Community College Partnership
US National Center for Advancing Translational Sciences · grant
This R25 Research Education Module, leveraging the infrastructure of the Indiana Clinical and Translational Sciences Institute (I-CTSI), will foster development of the clinical and translational workforce within Indiana through education an…
Posted May 21, 2026
Histology and Histomorphometry Core (HHC)
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY/ABSTRACT The Histology and Histomorphometry Core (HHC), Core B, will provide inhouse expertise, techniques, equipment, and technical innovation to facilitate ICMH investigators from vastly different subspecialties to use his…
Posted May 21, 2026
Enabling systemic delivery of europium-containing contrast agents for magnetic resonance imaging
US National Institute of Biomedical Imaging and Bioengineering · grant
The ability to image the presence or absence of oxygen is of paramount importance to the study of biochemistry, medicine, and multiple diseases. Hypoxia is linked to a variety of diseases including kidney disease; hepatic and neurological t…
Posted May 21, 2026
Omics Core
US · IL NIH · grant
SUMMARY The Omics core (Core 2) will support the overall U19 proposal by generating multiple layers of omics data from biospecimens collected as part of the well characterized cohorts of ADNI, MCSA and 5 ADRCs (Mayo Clinic, Indiana Universi…
Posted May 21, 2026